What genetic marker and population prevalence are mentioned for predisposition to CIRS?

Aaron Hartman, MDFunctional Medicine Specialist | Clinical Researcher

CIRS Episode 1 | Unraveling the Mystery of CIRS_ Genetic Predisposition and Biotoxicity

26 Jul 2024 · 1 min

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0:43

This is a short transcript excerpt from a YouTube video (CIRS Episode 1) featuring Aaron Hartman, MD and another speaker discussing Chronic Inflammatory Response Syndrome (CIRS). The speakers describe vague, multisystem symptomatology occurring along a continuum from biotoxic exposure to worsening biotoxicity and eventual CIRS, and they state that genetic predisposition (HLA-DR/DQ) affects a substantial fraction of the population (~20–23%).

Questions this video answers

HLA-DR/DQ gene (HLD HLA DRDQ), present in about 20–23% of the population.

Chapters

The symptomatology tends to be very vague and hard to pin down. And ultimately it leads to multi system issues that eventually precipitate in something called SIRS or cirs, or Chronic Inflammatory Response Syndrome. So there's a continuum from this timeline of biotoxicity to worsening biotoxicity to eventually, sirs. And they're not the same, but they are on the same continuum. And it goes from something with a genetic predisposition to exposure to eventually this state of dysfunction.
To tip off. Actually, the next question. Yeah. Is there a genetic presupposition? You answer that. And there is the HL D HLA DRDQ gene, which, like 20, 23% of the population has.
Yeah.
So potentially huge.
That's one out of five people. One out of four people, depending on.
What literature you're reading.