Aaron Hartman, MDFunctional Medicine Specialist | Clinical Researcher

CIRS Episode 2 | Did You Know_ How Mast Cells Adapt to Their Environment 🔬✨

3 Aug 2024 · 0 min

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0:27

Aaron Hartman explains how mast cells finish developing after leaving bone marrow, adopting whatever phenotype their tissue environment demands. If tissue is inflamed, mast cells become inflamed too. Clinical treatments that calm mast cells work only after existing ones die and get replaced by calmer versions.

On mast cells, when they leave your bone marrow, they don't leave fully differentiated. They actually go to the tissue that they eventually live in and take on the phenotype or the type, the. The appearance of those tissues. And if they go to inflamed tissues, they take on that inflamed phenotype. So when you start treating some of the mast cell stuff and doing some of the things you mentioned, you have to realize that these cells have to die off, and the next cells come around and repopulate that area and they'll be a little less inflamed. You have to wait for them to die off.