Aaron Hartman, MDFunctional Medicine Specialist | Clinical Researcher

Dr

30 Aug 2024 · 1 min

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A speaker (Aaron Hartman, MD) discusses a hypothesis that individuals with mast cell disease may have a relatively fragile genome due to impaired mutation-detection and DNA-repair mechanisms. During cytokine storms, potent mediators interact with genomic elements and may induce additional mutations, potentially worsening genomic instability.

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It's beginning to appear that folks with mast cell disease probably have a relatively fragile genome because these mutation detection and repair mechanisms probably are not. They have probably mutated themselves and are probably not operating as robustly as normal. So that when you have these cytokine storms, these floods of these very potent mediators, they come to have very complex interactions with different elements of the genome, and this induces additional mutations.

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