Which high-dose methylfolate product is named in the excerpt?

Aaron Hartman, MDFunctional Medicine Specialist | Clinical Researcher

Dr Achina Stein | The Hidden Dangers of Over-Supplementation

25 Jan 2025 · 1 min

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0:30

Short YouTube expert clip (Dr. Achina Stein) warning that excessive methylfolate supplementation can cause severe adverse effects — including suicidality in some patients — and that clinicians once widely prescribed high-dose methylfolate (Deplin), which harmed some people. Emphasizes the importance of appropriate testing before taking folate/methylfolate and not assuming a genetic SNP alone mandates supplementation.

Questions this video answers

Deplin

Chapters

I've had patients who have taken too much methylfolate and they've become suicidal. There was a time where many psychiatrists were providing patients deplin, which is a high dose methylfolate, and that has actually caused worse problems for some people. This is really important to know when a person needs folate. And so the testing is really important. Don't just take folate or methylfolate because you have the genetic snp.