Aaron Hartman, MD, in a YouTube video titled "GLP-1 Breakthrough," summarizes research showing that obesity-related traits can be transferred via the gut microbiome. He describes a twin-to-mouse fecal transplant experiment where obesity and leanness transferred between mice, implying the microbiome strongly influences metabolism, weight regulation, and insulin resistance.
Chapters
What if obesity and weight and metabolic issues were transferable between people? Have you ever thought about that? There was a really interesting research that was done between twins, and there's two twins. One was overweight and one was normal weight. And they took the feces from these two twins and put them into mice. And what happened was the obesity from one twin and the skinniness from one twin actually transferred to the mice. The research was extended, and they took the stool from those mice and then flipped it out. What they saw was the fat mouse then became skinny, and the skinny mouse became fat. There was something in the stool that was transforming from, from the adults to the mice, and then the mice between the mice that actually was related to the metabolism, to the weight loss, to the insulin resistance. So what we now know is the gut microbiome is a major driver for our metabolism.