Aaron Hartman, MD explains how gut bacteria trigger GLP-1, the hormone that regulates appetite and blood sugar. Akkermansia, Clostridium butyricum, and Bifidobacteria infantis are the key players. Pendulum is using these bacteria to help people with diabetes manage weight and glucose.
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The glucagon, like peptide 1, is a peptide our body makes that controls metabolism, satiety, insulin sensitivity, insulin production. But now we've actually been able to figure out which bacteria in particular have the biggest impact on the GLP1 MAINR GI tracts and can affect our metabolism the most. And there's bacteria Akkermansia, Clostridium butyricum, Bifidobacteria infantis. And there's one or two other bacteria that have actually been studied to see how they affect people's metabolism and sugar. There's a company called Pendulum that's been the head of this research for the last year, year and a half, and they've actually been looking at diabetics. How can changing the gut bacteria in diabetics actually impact their sugar levels as well as their weight? And they've actually formulated a couple of proprietary products that actually have these combinations in them.