Aaron Hartman explains how hypermobility triggers chronic stress, elevated cortisol, and leaky gut, shifting the immune system toward antibody reactivity that predisposes to autoimmunity. He notes 20% of Americans have positive autoantibodies, suggesting the condition is widely under-recognized.
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So it's really interesting to realize how much our understanding of autoimmunity has changed throughout the last years. But ultimately hypermobility by itself, because of how it affects your connective tissues, how it can lead to leaky gut, also can affect your cortisol because of the hyper alertness or arousal that's associated with hypermobility. Because your amygdala or your emotional memory is a little big, right? So you can overreact a little bit. This can be a survival trait. You can be hyper alert to your environment for survival, but in today's culture, times, etc. It results in chronic elevated cortisol which can cause more leaky gut. Elevated cortisol also tends to drive your immune system to a more reactive antibody type of immune system which there's only one hormone in your body that increases with age. What is that? It is cortisol. All the other ones, like thyroid, sex hormones, insulin, tend to become less produced as we age. Cortisol tends to go up. So all of a sudden, now hypermobility, gut issues, autoimmunity are all related. And once you realize that 20% of Americans have a positive autoantibody, maybe the numbers that 1 in 12Americans have an autoimmune disease are not quite right. Maybe we all have something going on, we just haven't realized it yet.