Hypermobility, Neurodivergence, and “Spidey Sense” Biology

16 Jan 2026 · 6 min
5:37

Aaron Hartman, MD argues that connective tissue dysfunction—specifically generalized hypermobility—is a common root contributor to many clinical problems. He links hypermobility (which he states affects ~20% of the population) to early/worsening arthritis, chronic musculoskeletal pain (including SI joint and sciatica), gastrointestinal dysfunction (IBS, IBD, SIBO, slowed transit/food intolerances), increased autoimmune disease prevalence (Hashimoto’s, RA, celiac), mast cell activation syndrome (part of a pentad with hypermobility, GI issues, dysautonomia, autoimmune problems), dysautonomia/POTS, and mood/anxiety disorders. He also claims a strong association between hypermobility and neurodivergence (speaker states a 400% higher likelihood) and describes the clinical observation of heightened sensitivity or “empath”/“spidey sense.” The speaker says Ehlers–Danlos syndrome (EDS) is rarer and will be discussed in a follow-up video to distinguish EDS from generalized hypermobility.

Questions this video answers

"20% of the population is hypermobile" (speaker claim).

"400% more likely" (speaker claim).

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