Aaron Hartman, MD explains that POTS itself doesn't shorten your lifespan, but related conditions like mast cell activation and hypermobility syndromes can. The bigger concern: depression and suicide risk in young people with POTS, plus harm from overtreatment.
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Can POTS kill you? If you look at some of the older literature, there's not really an association with decreased longevity if you have pots. But I have had some patients over treated. I had one young lady actually who was given IV fluids twice a week, a liter, and it didn't turn out very well. So sometimes people get over medicated. POTS has a lot of other comorbidities or comes with other things. So if you have POTS and mast cell or POTS and chronic Lyme or POTS and hypermobility, which go hand in hand, there's a lot of new connection with that. It's all connected. So those things can actually affect how long someone lives. But POTS proper by itself doesn't directly make people live less long. Can it kill you? It's more likely POTS doesn't kill you per se. It's what it can be associated with. There are a lot of people with lots of depression just feeling bad because a lot of young people have this happen to them and they can't do all the usual things they do, which can cause a lot of depression, suicidality, which is a high, high risk already in young people. And if you have pots, it makes it even higher.