Ben Greenfield describes his travel sleep routine using a high-dose (300 mg) melatonin suppository sourced from Dr. John Laurence of Mitozen (Sarasota, FL). He explains that rectal delivery provides slow-release overnight, avoiding oral absorption peaks, and that morning grogginess is rapidly relieved by brief exposure to sunlight.
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When I travel. To help me sleep, I use high doses of melatonin. I use a 300 milligram melatonin suppository, up 300 milligrams. I get it from my friend in Sarasota, Florida. He's a doctor, Dr. John Laurence. Wow. Company called Mitozen. And normally that amount of melatonin would not be absorbed well orally and would result in a large peak followed by a drop that wakes you up. This, by using the rectal delivery mechanisms, gives you a slow release of melatonin all night long. You wake up, and the problem is you're groggy because the melatonin is still in your system. Sure. So I walk over to my hotel room window. I pull open the curtains. The sunlight comes in, hits my eyes. Then five minutes, I'm fine.