Ben GreenfieldFounder, Ben Greenfield Life

Best Time To Take NAD So You Don't Mess Up Your Sleep

8 Nov 2024 · 1 min

Watch on YouTube

0:56

Short segment from a Ben Greenfield YouTube video about how NAD and Sirtuin 1 affect circadian rhythms and practical timing for NAD supplementation. The speaker claims NAD and Sirtuin 1 'rule over' circadian rhythms, warns that a large IV bolus of NAD can disrupt circadian rhythms for several days, and advises taking oral NAD supplements in the mid-afternoon to avoid interfering with Sirtuin 1 and sleep.

Questions this video answers

Mid-afternoon.

It can 'screw up' circadian rhythms for several days (i.e., disrupt them).

Taking NAD at the wrong time can decrease the efficacy of a Sirtuin 1 supplement.

Chapters

I actually use a lot of NAD too. Oh, oh. So let me stop you there. Okay. I went on this huge circadian rhythm binge and what I discovered was absolutely astounding because everyone, every time you go to a lecture on sleep, it's, you know, avoid external stresses, lights, food, exercise, et cetera before you go to sleep. But as it turns out, there are two proteins that put you to sleep. There are two proteins that wake you up and there are two proteins that increase the oscillation of those cycles. And NAD and Sirtuin 1 are they sort of rule over all of your circadian rhythms, all of these. So if you do a giant IV bolus dose, you are going to screw up your circadian rhythms for several days. The other interesting thing about it is if you take your NAD supplement at the wrong time, you can decrease the efficacy of your Sirtuin 1 supplement. So the best time to take it is actually mid afternoon.