A short conversational transcript (YouTube) featuring Ben Greenfield discussing ketone effects on exercise recovery and longevity. The speakers note that ketones act as an 'adaptive fuel'—promoting leucine-mediated mTOR activation and anabolic recovery when taken after exercise with carbs/protein, while in longevity contexts (calorie restriction plus ketosis) they are associated with decreased mTOR activation.
That's one thing about ketones that I love, is that it's almost like an adaptive fuel, because we have seen in studies with opposing effects. For example, we have seen an increase in leucine mediated MTOR activation when you take it after exercise with carbohydrate and proteins.
Leucine mediated MTOR activation. If you take ketones after exercise with regards to protein, what you mean is have, like, an anabolic effect.
Anabolic recovery. Yeah. And then if you look at longevity studies that has calorie restriction and ketosis, they are looking at decreasing in MTOR activation.
Right?
Right. Same thing with.
The grail of longevity, which drives me nuts, because you get all these people wasting away muscle. I'm like, you want to be, like, hard to kill as you age. You don't necessarily want to chase calorie restriction at all costs.
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