TRT shuts down your body's testosterone production and shrinks your testicles, while enclomiphene stimulates your own production and preserves fertility. Enclomiphene roughly doubles testosterone, raises sperm count, and doesn't create dependency. It's available from age 18 and works better for younger men or anyone wanting kids.
The difference between blood work of someone on TRT versus enclomiphene is trt. Their LH and FSH levels, as we talked about, are going to be near zero because you're shut down. Your testicles are going to shrink and you're dependent on it. If you go off of it, you're going to feel pretty bad. With enclomiphene, your LH and FSH levels actually typically go up because it's essentially telling the body, hey, you don't have estrogen, produce more. It actually makes your testicles bigger. Ironically, the studies that show the higher dosages, it actually increases testicular volume. Total motile sperm count, which is a key fertility marker, actually goes up. So it makes you more fertile as a man, and it generally doubles testosterone. The other advantage is there's no dependency. If you just stop taking it, you'll just go back to your baseline levels. You won't be shut down like you will with trt. So it's a lot safer of an option because it's not a lifelong option. Obviously, you can choose to take it if it's benefiting you, but you're not dependent on it. The huge advantages for guys under 50 or anyone who wants to maintain their fertility or have kids, it's a really great option because it's not that drastic, kind of lifelong decision that you need to make. And, you know, you can prescribe it to men as young as 18 because it doesn't mess with their fertility and in fact, it enhances their fertility.
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