51:15

In this episode of The Unlimited Podcast, host Brian Ginsler interviews longtime friend and former classmate Mara Lederman about her unconventional career trajectory and the evolution of AI in healthcare. Mara recounts her early fascination with economics, her PhD at MIT, two decades as a strategy professor at the University of Toronto’s Rotman School, and her leadership role at the Creative Destruction Lab (CDL), where she mentored deep‑tech startups. The conversation shifts to the pandemic‑era decision to co‑found Signal One with AI veteran Tomi Putonen. Initially aiming to build individual AI applications for hospitals, the company pivoted to a management platform that integrates, monitors, validates, and measures the value of disparate AI tools—a “Shopify for healthcare AI.” Mara explains why the supply‑demand imbalance in health systems creates a massive opportunity for AI‑driven productivity, citing concrete use cases such as radiology triage, AI‑powered voice agents for patient outreach, and an emergency‑department zoning algorithm that reduces wait times. She also shares her economic view of healthcare as a market where demand vastly outstrips supply, arguing that future care should be delivered in the lowest‑cost, safest settings, leveraging virtual care, outpatient surgery centers, and hospital‑at‑home models. The discussion concludes with advice for students and young professionals: learn how to learn, develop problem‑solving judgment, and use AI as a productivity complement while maintaining human trust and quality control. Throughout, Mara emphasizes the gap between theory and practice, noting that executing a startup is far harder than teaching it, and highlights the importance of trust in building relationships with large health systems.

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