Bryan Johnson tested rapamycin, an anti-aging drug, with different dosing schedules and blood draws to track how it moved through his body. He saw no benefits but got mouth cankers, slower wound healing, worse cholesterol, and a higher resting heart rate. The drug made him age faster by his own measurements.
First, this is what rapamycin looks like. It's a triangle shaped pill. Now, knowing the risks of having too much rapamycin in my body to suppress my immune system, but also wanting just enough for the benefits, we tried many things. We tried protocols, including five of these pills per week. We tried a protocol of six pills one week and 13 pills the next week, which I had 13 and 13. And then 90 minutes after taking the pills, we would take my blood and measure the level of rapamycin in my blood and then measure 24 hours later. 48, 72, 96. We were trying to assess how much rapamycin was in my blood. How fast did it decay? Back to zero. Now, knowing that information, we then could figure out, is the dose appropriate for the effects, then also narrow enough to avoid the side effects. Now, in doing this, I didn't notice any benefits. Everything seemed to be the same. I did, however, notice side effects. For example, I'd have cankers in my mouth, or maybe a wound wouldn't heal fast enough. My blood report showed that I had cholesterol disruptions. My blood glucose spiked a little bit. The thing that was most painful for me, it increased my resting heart rate, which, as you know from watching my videos, it is the most important biomarker I track every single day because it's the most influential thing determining my sleep quality.
