Bryan JohnsonFounder of Blueprint and Don't Die

How do we come up with the best framework for longevity? Data, Evidence, Protocol, Repeat.

2 Nov 2023 · 1 min

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In this excerpt, Bryan Johnson outlines his personal longevity framework, emphasizing a four‑step iterative process. He first conducts exhaustive self‑measurement, claiming to be possibly the most measured individual ever. He then evaluates the gathered data against the strongest available scientific evidence, acknowledging that interpretation can be subjective. Next, he designs and follows a strict protocol aimed at optimizing his health, striving for near‑perfect adherence. Finally, he repeats the cycle—collecting new data, reassessing evidence, refining the protocol—continuously iterating to improve outcomes.

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Given your markers, given what you have learned, what does the framework look like? What are the principles and the longest levers that you're looking at? It's a process of measuring extensively. I think I'm potentially the most measured human in all of history. Then it's taking that data and it's trying to assess the very best evidence. Now, that's, that's an art because, again, you scientists look at the same data and they come with different conclusions. So it's looking at the evidence, then it's implementing protocol in a subject like myself, where I'm trying to be perfect in protocol adherence, and then it's repeating data, evidence, protocol, and do it again and again and again.