I Edited My DNA On A Secret Island (To Live Forever)

Entrepreneur Bryan Johnson traveled to a private island in Honduras to receive an unapproved gene therapy designed to extend human lifespan. The treatment uses a circular DNA plasmid that expresses Follistatin protein, which extended mouse lifespan by about 30% in studies. The $20,000 procedure includes a kill-switch to stop it if something goes wrong.
Chapters
I'm traveling to a remote island for an extreme medical procedure that could change the future of humanity. Humans have a 120 year ceiling and so far no one can punch through it. Gene therapy might be the answer. This is a journey in search of the fountain of youth.
This is me as a kid. This is a kid who was born with one of the effects of the gene therapy I'm about to do in mice. When they received this gene therapy, they lived 30% longer. Let me back up and tell you how we got here.
In the shadow of the Caribbean lies Roatan, a hidden gem off the Honduran coast, shrouded in mystery. Beyond its breathtaking beaches and coral reefs, Roatan hides a secret venture, Prospera, an experimental zone for governance.
All this that you see is Prospera.
Prospera defies convention, crafting its own laws in a game of high geopolitical stakes against the Honduran government's backlash. I'm traveling to the heart of Prospera to find Mini Circle, a biohacking company rewriting the rules of wellness. Their target, Follistatin gene therapy, a pioneering technology with the potential to improve muscle and strength, slow the speed of aging and many more benefits. While becoming like the Bully Whippet and Belgian Blue who have a similar gene mutation is not my goal, it's interesting to see the results in our animal friends. After flying with Blueprint creative director Kate Tolo and our cameraman Jacob, we stopped off at Miami Airport where some people were curious about our mission.
What's your goal with the gene therapy? So it's the seventh ranking best performing lifespan extender in our list.
What is this procedure?
Oh, it's actually not that bad. I think they're about $20,000.
Oh, that's actually way less than a half.
Is it like injected?
Yeah, just a shot. It's a shot in the stomach and a shot in the buttocks. Bye, guys.
Thank you, guys.
Our next stop was Roatan Airport. But while I'd made it onto the plane, Kate and Jacob were still looking for me in the airport.
They're calling our names over the thing right now. This is a bad sign.
We're now preparing for takeoff. Sit back, relax and enjoy your flight.
After my failed crab rescue attempt at the Roatan airport, we met up with.
The founders of Mini Circle. How you doing?
I'm glad I get to be the.
Recipient of your work.
My name is Walter Patterson. I'm one of the founders of Mini Circle. Me and Mac founded it. We wanted to do something Impactful. We both went to school, you know, in the sciences. I went for biotech. He was in chemistry. We wanted something that would be impactful for most people's lives.
Until now, my team and I have avoided gene therapy because it seemed too risky. If a therapy caused, say, cancer in my body, there'd be nothing I could do to reverse the process. What makes Mini Circles therapy different is that it has a built in kit kill switch. If my body reacts badly, I can take the antibiotic tetracycline instantly killing and deactivating the DNA molecules I've been injected with. This treatment is not FDA approved in the US which is why I'm traveling all the way to prosper like I.
Would imagine as a fellow entrepreneur, the joy you must feel when someone lands and like this has been a labor of love for you.
My name is Mac Davis. I'm founder and CEO of Mini Circle. Sam Altman heard about it, offered us some money, and we started a company. The effects have been incredible that we've seen big muscle mass increases, big decreases in epigenetic age, and we're even seeing some lengthening of telomeres in some people. What we designed was a plasmid, a circular loop of DNA that was easy to subcutaneously inject, easy to manufacture, and could be loaded with any gene that we wanted to add to the human body. Super happy to share it with you. Yeah, this is as meaningful as it gets.
I'm gonna pick up some the best I can to maintain the blueprint protocol. So some veggies, berries. We'll do our best. Looks like they've got a pretty nice option set. Yeah, that's exciting.
Yeah, these are wetter and they have a lighter flavor.
Turns out they've got everything we need. With all my blueprint food bought for the day, we went to our hotel, had dinner with the Mini Circle team, and settled in for the night. Tomorrow was going to be a big day.
Today I will be receiving my first gene therapy. You know, I never imagined I grew up in a small town on a.
Farm with my grandpa.
And I never would have imagined that I would be doing gene therapy on an island off of the coast of Honduras. All right, we're ready to go. Crew rich dude doing all this crazy stuff for his health. Plus blood boy. Plus measuring nighttime erections, plus penis rejuvenation with shock therapy. Now in Honduras doing gene therapy. Yeah, it's quite a stack.
This could be the most powerful anti aging therapy I've ever received. To say I'm excited And nervous would be an understatement.
This is the same device I use for penis chocolate. Okay.
Brian.
Pleasure to meet you. How are you?
Very well.
This is a form that indicates that you're aware that you are operating within the laws of the prosperous ZA.
The only problem is it requires age 18 and there's no one here to sign for me. Okay. I may need you to jump in and do me a solid. As my Stan is my legal guardian.
I've been waiting for this moment. I'm ready.
As I get ready, I reflect on the magnitude of the moment. This therapy could have huge implications not only for me, but for all of humanity. Will it help me break that 120 year ceiling? We'll see.
Hey guys.
Hello.
Welcome. We're ready to go.
He's overcome with indecision.
Because there's something so.
Man, I know.
I already have the one. Okay.
All right.
Mm.
Yeah, that's great.
I guess she's a horse. We could drag your stab, but that's it.
Thanks, doc. Clean.
And injections.
Yeah.
Kiss.
What's that?
It's humanity's only objective.
Did you just get a step closer?
We got a step closer today. Yeah. I am now officially a genetically enhanced human.
Makes you really tall. Look how tall you are right now.
Good luck on your quest.
Thank you.
We appreciate that.
Thank you.
Enjoy the island. And safe travels to you all.
I'm gonna go try to pick up a car.
I bet you can do it.
Okay. All finished up. It's high UV index.
It's like 11.
Right now I need to test out the full fountain therapy, so I think.
I'm gonna run to the car. It. Sam.










