Bryan Johnson takes 13 mg of rapamycin with olive oil and measures his blood levels at 90 minutes, then days 3, 4, and 13 to track how the drug clears his system. He's trying to time doses so the drug reaches zero before the next one, avoiding buildup, though the effective dose for longevity remains unknown.
I'm increasing my rapamycin dose. I was curious about that one. Yeah, I keep hearing about it. You're trying to hit a spike in the sirolimus levels in the blood, and so you take the 13 milligrams. I take it with some fat. It's like olive oil. Then it has a half life decay. I've taken this and I measured my blood levels 90 minutes after taking three days, and then four days, and then 13 days. So you watch the half life decay. So what you want to see is you want it to get to zero, and then take your next dose again to avoid the compounded effects. And so now we've been able to model out to say we see that it decays least a zero in that time frame. So I can redo. So I'm going to try it. No one knows the effective dose yet.
