Bryan Johnson used Kernel's brain scanner to measure how ketamine scrambles neural activity patterns. His baseline showed stable traffic routes between brain regions. After ketamine, those patterns remapped, and over two to three days the brain rewired itself, creating a window for new neural pathways to form.
Like, imagine you're looking at planet Earth, and there's airports all over the Earth, and you're seeing traffic patterns between each airport. So between Tokyo and New York, there's a lot of traffic. London, New York, a lot of traffic. There's big traffic patterns in our brains of where activity is happening. When I did the five days of measurement, my patterns in my brain were stable. Every single day, they were the same, same traffic from the same place to and from. When I did ketamine, it scrambled all of my patterns. You took the globe and you just, like, remapped where all the airports were, and like, okay, planes start flying on day three, four, my pattern started forming back in a similar way. So there was that two to, like, one to three day therapeutic window where I was very open to new pattern creation.
