Bryan Johnson combined tirzepatide and CJC-1295 DAC but stopped after two doses when CJC-1295 boosted his growth hormone eight-fold but tanked his REM sleep, spiked blood glucose, and increased pancreatic workload by 53%. He warns that peptides are far more complex than the anecdotal protocols people follow online.
Remember when I said this? I'm going to stack two peptides with opposite side effects. I have the results. The experiment was to stack tirzepatide and CJC-1295 DAC, but after only two doses of the CJC, I stopped the experiment entirely. Here's why. The CJC increased my growth hormone by around 8x, which is exactly what you want, but it came at a price. It tanked my REM sleep, spiked my fasted blood sugar, increased my stress hormone and insulin resistance, and made my pancreas work 53% harder. And this is the bigger issue with peptides. People think that peptides do only good things in the body, but the reality is they're complicated. Most people's peptide protocols are built on subjective data and opinions from their friends and the internet generally. My goal with this experiment was to test a peptide, measure my body extensively, and then report out the learnings. If you expect a peptide to be clean and only good, it's naive. We don't know much about them. If you don't have the ability to measure your body, if you're using unregulated peptides that don't have clinical evidence behind them, I would just offer some friendly advice to be cautious. Experimentation is wonderful. If you're going to do so, proceed with caution and measure your body. Mm-hmm.
