Carlo CocuzziAI Expert, Pod Cast Host, Real Estate Investor and Funding Specialist

Lifespan: 50% Up to You | MOONSHOTS

11 May 2026 · 1 min

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In this segment, the speaker highlights a recent study that overturns the long‑standing belief that only 10–15 % of human lifespan is genetically determined, suggesting instead that genetics may account for roughly half of longevity. The speaker interprets this as a message that at least 50 % of how long we live is modifiable through lifestyle, medical, and preventive interventions. He recommends a systematic assessment of one’s genome, epigenome, and blood work to pinpoint actionable health targets, arguing that genetic information can guide personalized changes. To illustrate the point, he shares a personal story about his Ashkenazi Jewish family, whose ancestors typically died in their 70s or earlier, yet his father, by adopting healthier habits, has outlived that historical pattern, serving as a concrete example that genetics are not destiny.

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There's been a bit of a, a bomb thrown into the field recently with a paper, uh, just a few months ago that challenged the idea that only 10 to 15% of our lifespan is genetically determined, and they said it's closer to 50/50. So it's somewhere between 15 and 15, 50/50. We don't know exactly, but that's very difficult to modify. So at a minimum, I can say science says at least half of your lifespan is up to you, and the rest maybe fairly determined. But we should be looking at the genome and the epigenome and blood work and beyond. And your genetics will tell you what to focus on and change. My father is the best example. With Ashkenazi Jewish heritage, our genome sucks. We, we die typically— my ancestors die in their 70s. My grandmother had a stroke in her 30s. So the fact that my father is now living in a healthy way beyond any of his ancestors probably ever is testament that you can really change what your genes have given you.