University of Nottingham scientists created a fluoride-free gel with lab-engineered proteins that regrows real tooth enamel by mimicking how infants naturally form it. The regenerated enamel matches natural enamel in hardness, stiffness, and acid resistance. Human trials are planned next.
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Tooth enamel is the hardest substance in the human body, and it doesn't regenerate. University of Nottingham developed a biomimetic gel capable of repairing and regrowing damaged tooth enamel. So this is fluoride-free treatment uses lab-engineered proteins that mimic the natural processes of enamel formation during infancy. The treatment didn't just make something that looks like enamel; it regenerated layers and restored hardness, stiffness, water resistance, friction properties, resistant to brushing, chewing, acid exposure in labs. The gel. It acts like a scaffolding that pulls calcium and phosphate from the surrounding environment and directs them into properly organizing minerals, true enamel. I mean, for me, this is huge. Related oral disease affects, you know, half the population. It's estimated at half a trillion dollars per year in associated costs. This is still ex vivo. It's still effectively in the test tube or the Petri dish, but it's gonna be moving to human testing very quickly. And as someone who's had poor dental health and poor dental genetics all my life, I couldn't be more excited about this, especially for my kids.