Don't Let This C. diff Rule Trick You On The #NCLEX
30 Jan 2026 · 0 min
0:22
C. diff spores resist alcohol, so hand hygiene requires soap and water, not sanitizer. The mnemonic "C. Diff is different" helps you remember this on the NCLEX.
C. diff spores resist alcohol, so hand hygiene requires soap and water, not sanitizer. The mnemonic "C. Diff is different" helps you remember this on the NCLEX.
When you're dealing with C. Diff or Clostridium difficile, you must use soap and water for hand washing because alcohol based hand sanitizers, those are less effective against C. Diff spores. So remember this memory trick, all right? C. Diff is different. It needs soap and water, not just alcohol.
