Nitroglycerine Side Effects and Mechanism of Action | Nursing Pharmacology

15 Mar 2021 · 1 min
0:51

The video provides a concise nursing‑focused review of nitroglycerin. It begins by listing the generic name, common trade names, pharmacologic class (nitrate) and therapeutic class (anti‑anginal). Indications are explained, emphasizing its use for acute angina, myocardial infarction, and heart failure, as well as long‑term prevention. The mechanism of action is described: nitroglycerin is converted to nitric oxide, leading to smooth‑muscle relaxation, coronary vasodilation, increased myocardial blood flow, and relief of ischemic pain. Therapeutic effects include pain relief, increased cardiac output, and lowered blood pressure. Common adverse effects such as dizziness, headache, blurred vision, hypotension, syncope, tachycardia, and GI upset are outlined with their physiologic basis. Nursing assessment priorities are highlighted: frequent monitoring of blood pressure, heart rate, and continuous ECG for IV administration. Major contraindications (e.g., increased intracranial pressure, severe anemia, pericardial tamponade, hypovolemia, glaucoma) are listed. Patient education points cover correct dosing timing, positioning to avoid orthostatic hypotension, avoidance of alcohol, storage in airtight light‑blocking containers, and instructions for sublingual, oral, and transdermal routes, including when to repeat doses and when to seek emergency care. The video concludes with promotional messages for additional nursing resources.

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