EP 3:57 The Neuroscience of Addiction with Dr. Nicole Labor

22 Oct 2026 · 49 min
49:27

In this Aftermath Podcast episode, host Dallas Bragg interviews Dr. Nicole Labor, an addiction medicine clinician and author of Addictaholic Deconstructed and Addictaholic Reconstructed. The conversation centers on the neuroscience and lived experience of chemsex—sexualized drug use, especially among men who have sex with men, involving stimulants like methamphetamine, mephedrone, and GHB. Dr. Labor explains why addiction can be viewed as a disease, describing maladaptive learning, dopamine flooding, and receptor down‑regulation using a baseball‑field analogy. She expands on glutamate’s role as the “executive assistant” that cements drug‑sex pairings into powerful learning loops, leading to cue‑reactivity, cravings, and the difficulty of stopping use. The discussion covers the unique “stacking” of sexual and drug cues in chemsex, the bargaining nature of cravings, and the challenges of cross‑addiction (e.g., substituting meth with cannabis, kratom, or process addictions like porn and gambling). Dr. Labor contrasts harm‑reduction approaches with abstinence, noting that tapering reduces external harms but does not quickly restore brain receptors. Practical recovery strategies are offered: interrupting loops with physical actions, blocking triggering apps, building new “roads” through meaningful activities, cultivating purpose, learning to tolerate boredom, and using streak‑counting as motivation. The episode also touches on family dynamics, boundaries, and the post‑abstinence phase—how to find meaning and rebuild life after quitting. Throughout, Dr. Labor emphasizes that all addictions share common neurobiological pathways, and treatment should address the underlying dopamine‑glutamate circuitry rather than the specific substance or behavior.

Chapters

More from Dallas

1:00
youtube.com

First Love

today
0:59
youtube.com

Understanding Chems//x Addiction

19h ago
1:31
youtube.com

Group Coaching

23h ago
1:48
youtube.com

Your Responsibility in Recovery

1d ago
1:02
youtube.com

Interrupt Patterns in Chems//x Recovery

1d ago
0:36
youtube.com

Sharing Your Story

1d ago
1:16
youtube.com

Pre-meditated Relapse

2d ago
0:16
youtube.com

The Neuroscience of Addiction with Dr. Nicole Labor

2d ago
1:05
youtube.com

Group Coaching

2d ago
0:45
youtube.com

Group Coaching

2d ago
1:51
youtube.com

Fail Proof Relapse Prevention

6d ago
See all content