Episode 504: Exploring the Clinical Side of Medical Cannabis with Dr. Hemant K. Bid

Welcome to Cannabis Health Radio, where healing stories meet science. Join Reverend Dr. Robin Swann as she talks with patients and experts about the healing power of cannabis and other sacred plant medicines. Trusted information, real experiences, new possibilities for healing. Cannabis Health Radio starts now.

Hey kids, how's it going? Here it is, another day to do another recording for Cannabis Health Radio, where we're gonna introduce you to an amazing human being who is moving the medicine of cannabis forward. Welcome, our guest. Dr. Bid is a pharmacologist, cancer researcher, biotechnology educator, serving as the program director of the Master of Science in Biotechnology and Medical Cannabis. Therapies at Morehouse University in Atlanta. Hello, Doctor. How is your day going?

I'm wonderful, Robin. How are you doing? And thanks for inviting me. It's a pleasure to be here and excited to have a great conversation with you guys. Okay.

Yeah, I'm so thrilled. So can you— there's so much I want to go over with you because you have just such a wealth of knowledge, but I'd really like to know how you even came to the conversation of cannabis through pharmacology. What brought you there? So if you can just share your journey to present, that'd be great.

Yeah. Yeah. No, that's an interesting question actually. And cannabis pharmacology, I think that one of the most fascinating subjects that always fascinates me. And my background is basically biochemistry. So I've been working in the field of cancer drug discovery and cancer pharmacology from last 27 years. And in the field of medical cannabis research and education for 15+ years. Working in the field of cancer drug development, especially that cancer is a multifactorial and polygenic disease. So many different factors are there and single therapy won't work. There are multiple combination of therapies are there. But along with that, I think that medical cannabis in the forefront that, you know, like it gives a huge hope for multiple different disorders, including cancer, where that it can provide a better quality of life to the patients. So that means that the patients who are under chemotherapy or radiotherapy, et cetera, Then they lose their appetite and they are under depression and they have anxiety, they have pain, and medical cannabis can be a very supportive therapy and provide a better quality of life. But thinking of that, that if you think about neurodegenerative disorder also, Parkinson's, Alzheimer's, ADHD, and so on. So multiple sclerosis. So basically that like every patient have those kind of issues and they are having on clinical drugs.

Yeah.

But when you are using the medical cannabis therapy, then you know, like there's a lot of kind of like questions that we ask in the clinical side that how medical cannabis interact with various different current medication. Because if you think about that, that so far the discovery of the major cannabinoids CBD and THC, that it has a lot of research has been done on the pharmacology of cannabis and CBD and THC has effect on cytochrome P450, which is a liver metabolizing enzymes, right? And cytochrome P450 is a very important enzyme, and it's kind of like it has a lot of interaction. So this is kind of like prompt a very good conversation that if that's the case, then cytochrome P450 enzyme system is a major drug metabolizing pathway in the liver and the intestine as several cannabinoids, but including particularly TSC and CBD can inhibit or otherwise activate the cytochrome P450 enzymes. So that means that it need to be studied for any kind of disease, for cancer or Parkinson's, neurodegenerative disorders. When patients are taking any drugs, these drugs has been metabolized. That means metabolized means they are going to break down.

Right.

With the help of liver and your intestine. And then after that, it gives you the effect that the, how the, that effect need to be done in the cancer patients or the Parkinson's patients. Right.

Okay.

Then what happened that when we are talking about that, these drugs are showing their effect because they are metabolizing by liver and intestine, and they have certain enzymes there that which does that. Now that when we talk about the cannabis, CBD and TSC has a particular effect that which influence the effect of these enzymes in the liver. So either when you take the CBD and TSC with these drugs, maybe they can be more effective or less effective.

Okay.

So that's why the pharmacology comes here handy. Because if, why it is comes here handy and it is important because let's say that CBD is helping somebody's anxiety, but CBD is trying how it is affecting the liver enzyme. It'll reduce the effect of the cancer drug.

Yes.

That's a very important point that you make a lot because I have learned through my studies and research that immunotherapy and cannabis are not great bedfellows. And a lot of people reach out to me in my company who are doing immunotherapy. And when I tell them that, you know, cannabis is not— is contraindicated with their therapy, they're shocked and they don't understand. So can you speak to that? Just that cannabis, even though it's a plant, is not necessarily going to work with everything that is a chemical.

Yes. So that's a really good point, actually. And being working in the field of cancer biology, I can tell you one thing. That we scientists work in the cancer biology and various different, trying to figure it out, various different ways to block cancer cells. In a simple way, where, how you explain the cancer is, I always tell that it's an uncontrolled cell growth. Uncontrolled cell growth.

Exactly. Yeah.

Yeah. So basically what happened, why this uncontrolled cell growth? Because there are multiple factors behind that. Multiple genes behind that. So we know that there are so many factors, either it is preservative, either it is radiation, either it is XYZ, and multiple genes in our body. They play important roles so that somebody had cancer, right? So what happened in cancer that our body is a very balanced machine, and when this happen, one cell get rogue. So then the cell said to the body that hey. I know that you want to control and balance the whole body, but I am not in your control anymore because I have some kind of mutation happen in my cell and I am free from you. But then I get a power. The power is that continuously dividing that I love. I'm going to divide. That's it. That's what I want to do in my life. Right? So that is called uncontrolled cell growth. Right. So it is also important to talk about a little bit about that, why we get the benefit from medical cannabis. Oh, okay.

Yeah, we're gonna talk about it a lot.

Exactly. Right.

Yeah.

So the simple explanation for me is that plant is produce the cannabinoids, and when anybody consume cannabinoids, so then there is a unique system in our body. For example, our body has a, you know, reproductive system. Our body has an immune system. Our body has a respiratory system. There is another system which is called endocannabinoid system. So I always tell that phytocannabinoid, that means P like phytocannabinoids and P like plant. So when the plant produce the phytocannabinoids that interact with endocannabinoids, you get the benefit. Simple. The interaction between the phytocannabinoids and endocannabinoids You get the benefit of medical cannabis. Now that you have to also think about that, okay, this is true and this is very nice explanation, but then why cannabis has so much application? How come cannabis is helping patients in neurodegenerative disorders, in pain, in cancer, in Alzheimer's, ADHD, multiple sclerosis, you name it, right? Or skin disorders or bone disorders, et cetera. So then again, go back to the endocannabinoid system because any system in our body is basically made of lock and key system. So that means lock and key means lock is the receptor and key is the key. So that means molecules go and bind with the receptors and then activate the signaling pathway in the body. So now that this receptor in endocannabinoid system is CB1 and CB2 receptor. Major receptors. There are so many other receptors are also there, and then cannabinoids are worked like a neurotransmitter, and then they bind and they activate. Now that you know, this is really important for every listener to understand that when we talk about the receptor lock and key, that why cannabis is so much helpful because these receptors CB1 and CB2 express in every part of our body. Everywhere you talk about brain, you talk about spinal cord, you talk about immune cells, you talk about skin, you talk about nervous system, you talk about reproductive system, it's everywhere. So now everybody start thinking that Dr. Beard is talking about endocannabinoid system and phytocannabinoid system, they interact, medical benefit. Now he's also talking about that endocannabinoid system is a lock and key system And this key is present in all over the body as CB1 and CB2 receptors. So now why it is so beneficial? Because when the receptor is present in your liver, or let's say that in your reproductive system, right? So that means that this endocannabinoid receptors play an important role to maintain the normal physiological function of this specific organ. Simple. So that means it is present there and it is maintaining the normal physiological function of liver, brain, bone, skin, everything.

So then is it wrong to assume that cannabis does not— that cannabis plays well with all drugs, or are there other— because pharmacology, pharmaceuticals are chemical-based. All right. When you put chemicals into the body, it changes up the dynamic of the body. when you add a plant to it that is maybe contraindicated to those chemicals, it creates a reaction. And that's my question. Are there any drugs, especially in the chemo family, where cannabis is contraindicated to use?

Yeah. So that's a very actually loaded and big question, actually. Yes, of course. Because pharmacology of cannabis is a really big field. And again, that it is in some—

Just bring it down to like just the smallest understanding.

Yeah. Yeah. No, no. One example. Yeah. I'm going to give you one example that yes. Cannabis is beneficial and also interact with the other drugs. That's why pharmacology of cannabis is important. As I mentioned that some instance, let's say that drug A, or let's say that, you know, like warfarin, which is a blood thinner, but it has a good interaction with CBD. And blood thinner is very sensitive drug because somebody has a problem that, you know, they are not— blood is not coagulating and they're kind of continuously, you know, uh, Right. If any cut there, then, you know, like it's a disaster, right? So that means that if that person has anxiety or depression or for any other reasons or cancer and they are taking CBD and THC, they have to monitor the level of the drug they are giving, warfarin, with respect to CBD, because then the, the how CBD is going to affect the INR ratio based on that The doctors can manipulate and up and down the clinical side of the drug to help the patient to maintain a balance so that patients can get the help from medical cannabis without affecting the, uh, real drug, which is not the real, the clinical drug that which they are getting, uh, for their any other anomalies, like either for blood thinners or chemotherapy or either immunotherapy, et cetera. So that means that that's the, the simple answer is that it has the interaction, but different—

Good or bad interaction is the question. Like, is it a good interaction? Is it okay to do immunotherapy and cannabis? Because that is okay. Like, I kind of wanna know. That's a good question.

Yeah. Again, that it needs a lot of research, but so far that what is happening is again comes to when you talk about immunotherapy, right? Immunotherapy is, what is immunotherapy? First, everybody need to understand that. So we did a lot of research in cancer from last 50, 100 years, and we are talking about small peptides, big molecule, monoclonal antibody, checkpoint inhibitors, everything. And then we are saying that, okay, all the therapy is not— some cases they are working, some cases not, most of the cases not working. So now that, you know, like, because cancer cells are very smart, they were part of our body, They know our body's defense system. So that's why the drug don't work very well. So, but the cancer cell said that, okay, if you are giving me a drug A and it is blocking this pathway, I will go this way and attack, right? So then what happened that we are scientists and we are very smart. So we tell the cancer cells, okay, you are going to play this game. What we are going to do is that now we don't have any other option. We come up with a unique option which is called immunotherapy. So what we are going to do, we are going to take the cells from our own body, immune cells, and then tweak them, edit them with the help of a very unique gene editing technology which is called CRISPR-Cas, which got the Nobel Prize 2 years ago. Okay. Why we are tweaking the immune cells? Because cancer cells are very smart, as we talk. So when they are there and body's own cell, immune cells, are trying to attack because body is body is very trained like that to maintain the balance. Oh, there is a cell which is cancerous, not good for us. Let me cell and let me send my immune cells to destroy them. Then you know cancer cells what they does? They call there's a signaling pathway. They release the signaling pathway. It's very funny. This signaling pathway called don't eat me.

Signal.

Okay, so scientists give the name don't eat me signal. So cancer cells release this signal to the body's immune cells, who are the fighters, and say, please don't eat me. Remember, I was in your team. I was the family member. I'm your friend. Okay, so they actually make them confused. So then they make them confused. They throw the spell. And then what happened? Then as a scientist, we realize, okay, now body's immune system is not working. We need to do something. Okay, what we need to do, we need to retrain them. So that's called immunotherapy.

So beautiful explanation. Thank you so much. I appreciate that.

Yeah. So we take out those cells, we retrain them and put it in the body again. And then now that when cancer cells are trying to make them fool, These retrained new warriors said that, hey, you know, I am not a fool anymore. I get new weapon and I get trained better, so I can see that you are the intruder. You are not the good guy. I'm going to attack on you. Okay, so that's the one explanation of the immunotherapy. Now, why there is a contradiction between cannabis and immunotherapy again goes to the same concept, because the immune cells in our body, all the different immune cells. C cells, T cells, B cells, um, you know, like lymphocytes, etc., they all have the expression of CB1 and CB2. So that means cannabis is going to interact with them.

Right.

So now the question is that, you know, like, is it good or bad? That's very hard to tell in the sense for right now because, uh, there are not very much research there out there, right? So that's the one of the biggest issue that what we are having, especially talking with the immunotherapy, because immunotherapy worked basically on immune checkpoint inhibitor, which is the T cells, right? And cannabinoids, particularly THC, have immunomodulatory and immunosuppressive effect on T cell activity and cytokine signaling. Because as I said, that based on the expression of the CB1 and CB2 receptor, THC affect the activity of T cells. So there is the interaction. That's why they call that, you know, like, okay, if you are in immunotherapy, better not to use it because we are trying to understand, but we don't fully understand that because there's not so much clinical data is out there. And remember that, Robin, that, you know, like one of the biggest challenge in the medical cannabis field is the consistency the purity and potency of the product. So that means—

Are you guys not like the Technion in Israel and growing your own weed? Do you not have that at Morehouse? Is there not a big greenhouse?

No.

In Atlanta, in Georgia, state of Georgia, they started 2015 and approved low, low percentage of THC oil only.

Right.

And happy to share—

But they approved high CBG. Like, the state of Georgia seemed to really enjoy the cannabinoid CBG and give it a lot more grace within their conversations and licensing.

Yeah, because it's all—

I'm sorry.

Yeah, it's all about that, you know, like who are the legislators who are navigating the thing? There are so many factors there, right? And, you know, the people who are supporting the program, are they pro-cannabis or they are anti-cannabis? There are so many things are there. And also that, don't forget that it's not about pro and anti, but it's about that How much they're educated with the current research.

That's a big— and there we go, because of the whole scheduling and all of that. So how did you, how, how did this come up? Like, I'm just so curious. Were you like just doing bong hits during medical school and you were like, wow, this is an amazing medicine? Is it because it's culturally just part of your lineage for your entire life? Like what brought you to this, to this plant? Like where, where in your scientific little journey? of medical school and research and chemicals, did you go to the right and go, wait a minute, this plant's like amazing. How do I, how do I incorporate this? Your personal journey, not the science.

You. Yeah. No, no. That's an interesting question actually. As you know that, you know, like India has a cultural and religious infusion of medical cannabis from decades, right? Yeah. I grew up with this.

Given to us from Shiva. Yeah.

Like it's the same thing.

Yeah.

Yeah.

Yeah.

So I grew up with the plant, you know, like we have so many cultural activities and also religious activity where we use the plant leaf and all this stuff and everything. So it's just a very common norm for me that, you know, like we have a big festival, it's called Festival of Colors, that, you know, like people use and enjoy the Festival of Colors, etc. But that is one thing that we should normalize. But also that, you know, like when I finish my PhD, And then I joined as a scientist in Natural Drug Development Institute, one of the topmost natural drug development institute in India. It's called Central Drug Research Institute. And I worked with a lot of natural product chemists, and they were kind of isolating the compounds from marine creepers and, you know, like leaf, bark, and so many different things. And also that, as you know, that in India, Ayurveda is a big hub, actually. So Then I, that time my interest actually started with medical cannabis. So we started researching that and all this stuff and digging actually that, okay, what's happening in India and what happened in outside, what kind of research has been done. And it's, it's kind of like amazed me that, you know, like that time, because being coming from a cancer biology background, that how much it is helpful. And one compound or one plant can help in the cancer patients in 10 different ways. It's amazing. It can help to sleep. It can reduce anxiety and depression for cancer patients. It can control the cancer cachexia and anorexia, which is the muscle wasting disorder. And also that, you know, like, it can be a potential anti-cancer activity. It can block the cancer angiogenesis metastasis. So it intrigues me. And then I started actually learning more. But, you know, like, then I realized that, you know, like, the amount of research and discovery happen. in other countries, India is behind, even though in a raw plant we are using it, but in science is behind, right? And it's the same thing that how it has been put in Schedule 1 here, it has been put in the Narcotic Act in India.

Mm-hmm.

It, it was in a Narcotic Act. So that means that you are going to, uh, be in a jail if you are consuming it and all this, you know, regulatory framework and all this stuff.

Yeah.

So that's what's— and then I came for, uh, postdoc. My studies, and there actually I got the opportunity to do more research on that, which fascinates me. And then after that, I was running my own company in Michigan, and then I realized that working with various different cannabis organizations, that education is really, really missing in this area. And why? Because there are not a lot of people who really understand the science behind that and really don't understand the value of the science. So I joined my first actually venture, Cleveland School of Cannabis, which is in Ohio. And I actually was a curriculum director and then developed like 6, 7 courses of CBD comprehensive, endocannabinoid research, and, you know, like policy cultivation, et cetera. And then I realized that, oh my God, this is really fun. And also that it is creating a lot of value. And from there, actually, that, you know, doors keep opening up. I joined St. Louis University, developed pharmacology of cannabis there. I was the scientific director for CP Lab, which is a cannabis testing lab that I developed the whole lab in Columbus, Ohio. And then finally doing all those things, and I teach at College of DuPage, which is the top 5 horticulture college at the state of Illinois, hemp and cannabis cultivation. And also that, you know, Olive Harvey Community College, where I teach medical application as well as the testing part also. So it'd been fun ride. And then when I joined Morehouse as a biotechnology program director, Then I realized that the connection is missing between the biotechnology and the pharma, that how we are going to use these tools to kind of like, you know, create this value proposition. Because if you think about that simple thing in pharma, right, that if you ask me that, you know, like, okay, let's get ibuprofen or Tylenol from California, from Michigan, from Ohio, from Georgia. Everything is same. But if you ask me that, Dr. Baid, go and collect the different products of medical cannabis, it's completely different. So that means one of the biggest thing is the standardization, but you cannot standardize a plant, period. But we are trying to do that, you know, and again, plant is meant to be grow outside.

But what we can standardize, because this is a conversation that we can explore too, as a formulator of cannabis medicine. People will come to me with very little education and start talking to me about strains. And my response to them is that it's not about strains, it's about cannabinoid profiles. Can you— and if we can get similar cannabinoid profiles, meaning like, you know, a certain amount of molecules of THC to CBD to CBG to CBCC or on and so forth, we're gonna get it not a standardized medicine, but something that's going to be more congruent across the So am I correct that it's not about the strain, that it's about the combination of cannabinoids and that it doesn't matter what you process because every plant is different by every grower?

So, uh, this is like a really big conversation, right? That, you know, like, is it about—

But we're, you know, you can just, you can give me the Cliff Note of it. Okay. 'Cause you and I can geek out for days. I know this.

Yeah, so basically that, you know, when we talk about strain versus cannabinoids, right?

Yes.

So strain is a commercial and consumer term. Different strain can have different combination of concentration of the cannabinoids like THC, CBD, CBG, CBN, etc., terpenes. But strain names such as OG Kush, Blue Dream, etc., are not standardized Pharmacological categories. Yes.

Thank you.

Full stop.

Full stop. Did y'all hear him? That strain names are not cannabinoid profiles, period. Full stop.

Yeah.

They need to know that. They just need to know that. It's very important.

Yeah. Because, because the thing is like, you know, like 2 products sold under the same strain name can have substantially different chemical profiles.

Yeah, exactly. Exactly. So it's the combination of cannabinoids, which we get from combining multiple strains That create that real beautiful full spectrum of the cannabinoid, of the cannabis.

Yeah, because, because the question that we are talking about, the immunotherapy, right, about immunotherapy. So the, the better scientific question is which cannabinoids at what dose and what exposure are effective immune signaling rather than, you know, like we are talking about that, you know, like strain and, uh, cannabinoids. Because again, there's always a lot of, you know, like a crossover or kind of like a lot of confusion is that, and I think that clarity is really important for the consumers to understand that because every plant based on the different geographic, geographical reason that I serve as a consultant for 2 different companies in India. One is that in Northeast and one is in Upper Himalayas. And because of the geographical location, Yeah, it's very important. The plant thrive. In a different way. And that's the beauty of this plant, because that's why that we call that this plant is amazing, because this plant has so much application and it's so adaptable.

Oh, it's a gift to us from the holy creator, as you know. I mean, that's why Shiva brought it, right? Yeah, to serve us in all different ways. So it's kind of a bigger, broader question, but where are we at as we talk about rescheduling the cannabis drug? Is that going to be helpful for You know, pharmacology, is that gonna open some doorways for us in secular medicine to be able to, you know, begin to receive cannabis as a—

Yeah. Yeah. So I think that's— yeah. So I think that, you know, like rescheduling is really a big, you know, like step happened, right? You know, like when we talk about rescheduling, because everything was stuck based on that it's a Schedule 1. So that means that, you know, everybody gets scared that, okay, this is heroin and cocaine, same level. What should I do? Doctors back off, nurses back off, clinical side back off. But reality is that it should not be there, right? So finally, that, you know, like things are moving in the right direction. And when you talk about that, you know, like what are the going to be potential advantage of the rescheduling and it is going to happen soon? No, it will take a long time because it's all regulations, policies, paperwork, etc. And then state regulations are different. In US, federal level is different. So it's all need to be in the same page in the connecting the dots, basically, right? But in a nutshell, you will see more research. More research, more clinical side research generate better evidence for cannabinoids and their application.

And where do we find your research? Where can people reach out to you, find papers you've written?

Yeah, so if you, if you, um, uh, if everybody is, you know, familiar with the— because, you know, like, there are a lot of things that you can do that you can go to Google and put my name and cannabis, and then it will come up with a lot of different podcasts. And if you go to YouTube and you put my name and then cannabis, then there will be a lot of podcasts there. I give a lot of podcasts.

Do you have a YouTube channel, or is it just— No, I don't have the YouTube channel, but So we need to get you a personal assistant. That's what needs to happen right now.

So, so I actually give a lot of talk on various different platforms which are a lot of traction all over the US and globally that, you know, like where I talk about the acidic cannabinoids, which is like really big. And why it is big? Because last 50 years or 100 years globally, if you see that we do the research on CBD and THC, all the research force focus on CBD and THC. Question is why CBD and THC only, right? If plant is already have more than 100 cannabinoids sitting there, then what's the challenge? The challenge is the very advanced extraction technologies.

Exactly.

But then when we talk about the acidic cannabinoids, then we always talk about, and I give the always, you know, like the challenge that, you know, like if plant is producing all the cannabinoids in acidic form first in the flower, then there is a reason to that. And then we decarboxylate and then we get the neutral cannabinoids, right? But we don't had that technology that now we had it. So I worked as a consultant for Essentia Scientific, which is California-based company, and we have a unique technology. We leach out acidic cannabinoids with the help of water. No chemical.

Oh, wow.

Wow.

That's incredible to me because it needs fat to extract it. So, or so now you're finding ways to pull it apart with water.

Yeah, it's all about that, you know, centrifugation and, you know, like what speed you are doing. It's a very unique technology, right?

So exciting. It's so exciting.

Yeah. So then what happened that this acidic cannabinoid, now more research is coming. And why it is coming? Because acidic cannabinoids can cross the blood-brain barrier. Yes, that's a big, big, big, big issue. And then also it's unstable, but because of the chemical structure that chemists are kind of manipulating the structure to give them the stability. Once they are giving the stability, it increases their bioavailability a lot than the neutrals. Big advantage. And also think about that when you compare TSC with TSCA. TSC has the psychoactive part, TSCA don't have the psychoactive part, but similar and more better effect than TSC.

Exactly. Thank you, thank you. Okay, we, we, um, you have to come back to Because in this podcast is that we start with science, that we, you know, we really start with science because yes, cannabis has been with us for always and since always. It is a sacred herb that, you know, is we're designed to receive, but our brains have evolved and so have our chemical understanding.

For sure. So, and also, you know, like I would suggest one thing also for next episode that if you send me a list of the specific questions, Then I create a specific PowerPoint also that based on the visualization so that, you know, like our audience can love that in a very simplified way that I can share with them that, okay, look at this and how this is kind of like, you know, like decarboxylated. Decarboxylation means that, you know, like CO2 moiety is released and this is the neutral cannabinoids. And that's how that, you know, like acidic cannabinoid turned into the neutral cannabinoids. But definitely there are a lot of, you know, like, and also one of the things that which I'm trying to integrate and see that the application of artificial intelligence and machine learning in this growing, growing field, because it is already taking over the biotechnology field.

Wow.

Another conversation that we're gonna have to get the robots involved in.

Yeah. So, so, so just to kind of very summarize, to tell you that, you know, like not to go in great detail. But, you know, as you talk about that, that you are talking about that, okay, why, Dr. Baid, that, you know, like there's the importance of pharmacology because of the drug-drug interaction, right? The clinical drug with the medical cannabis. And that can be very easy because AI, artificial intelligence, can analyze the drug and the cannabinoid dataset.

Do we love that? Do we love that, you guys? I hope you all understand what he just said. Yeah, that will help know which cannabinoids are going to treat what's going on with the person more directly than just high THC. Right. Yeah. Yeah.

And also, also remember that, you know, like, as I mentioned, that cannabis therapy is a personalized therapy. Amen. It is.

I always say that it is homeopathy and that it's unique as your thumbprint.

Yeah.

But, but, but also that everybody needs to understand that why it is a personal therapy. Same goes to the back to the basics that phytocannabinoids and endocannabinoids. Endocannabinoids has the two part, which is the receptor and the molecule. This receptor express in different part of our body, but then everybody express this receptors in a different level. And how it affect? Let's say Robin has a lot of expression of CB1, CB2 receptors in our body. That means. even though 2 milligrams of full spectrum will be very effective for Robin. Why? Because when Robin consumes the cannabinoids, it will go and it don't need to go and find different places because she has a high expression or genetic expression of these receptors in her body. It go and bind and give his effect. But on the other hand, Dr. B needs 10 milligrams. Why? Because based on the genetic analysis and sequencing, Dr. Bate's body express 10 times less expression of CB1 and CB2. So that means when Dr. Bate is taking 2 milligrams, which you took, this molecule is keep confused, cannot find the receptor in the body because I have very less expression, right? So that means I need to increase the numbers so that they can be everywhere to find easily the receptor.

Oh.

That is called the personalized therapy.

Yes.

That's how that everybody is different. But now that, think about that, we are moving to a next level. This is called pharmacogenetics. So that means that now companies created a sequencing kit that where you go and give your blood, and then it's kind of like sequence CB1, CB2. you come up with that result to the medical doctor and say, hey, you know, I have this expression level and I want cannabinoids for my multiple sclerosis or fibromyalgia. And they will say, okay, looks like you have pretty good expression. And based on that, they can find the right match. So it's called collecting the data.

And let's stop right there because collecting the data is a great place to wrap this up. And you have given us So much to think about and so much knowledge. And I'm so grateful that you are spending your time just giving this knowledge back to all of us. And, you know, we are going to definitely tell the world about you, Dr. Bin, and we will see you soon.

Yeah, definitely. It's a pleasure to be here, Robin. And it was a great discussion. And anybody wanted to reach out, my LinkedIn is there that, you know, like you can figure it out there that you can find me. You can find more House School of Medicine websites, and you can find all the details there that what I have been sharing with all the networks. And I'm hoping to discuss more detail in various different aspects of medical cannabis, either it is the clinical side, extraction side, cultivation, and also that, you know, patient side. And most exciting part is the one of the biggest my venture right now is the application of artificial intelligence and machine learning. and their application in medical cannabis. I think that it will be a very interesting conversation.

I think so too. And we will put all of the ways to contact you and find you in our show notes, and we will be back in touch. Thank you so much, Dr. Bid.

Thank you, Robin. It's a pleasure to be here.

Thank you for joining us for this episode of Cannabis Health Radio. We hope today's conversation has reminded you that healing is possible and that you are not alone. If you found this episode valuable, Please share it with someone who may benefit. Every story shared helps bring the good medicine of cannabis to more people. For more episodes, educational resources, and community, visit cannabishealthradio.com and consider joining our Patreon family, where you'll connect with like-minded individuals as well as help support our work. Until next time, stay informed, stay curious, and keep advocating for yourself.

I'm Reverend Dr. Robin Swann.

Thanks for listening.

Thank you.