From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292

21 May 2026 · 106 min
Episode

21 May 2026 · 106 min

0:00

In this episode of This Week in Startups, hosts Jason Calacanis and Lon Harris interview three guests: Lukas Czinger, co‑founder and CEO of Divergent Technologies; Brandon Good and Dr. Mark Horowitz of Outro Health. The conversation begins with Czinger’s vertically integrated, AI‑driven metal additive manufacturing platform, its origins in hyper‑car development, and its expansion into high‑volume defense and aerospace production such as airframes, cruise missiles, and drones. They discuss production economics, certification for military customers, and the shifting landscape of prime versus neo‑prime contractors. The show then shifts to Outro Health, where Good explains the incentives that drive the pharmaceutical and insurance ecosystems around antidepressants, the clinical inertia of generic SSRIs, and the company’s business model of medication‑management and bundled‑payment pathways to help patients taper off psychiatric drugs. Horowitz adds detail on the side‑effects of long‑term antidepressant use—sleep disruption, cognitive impairment, weight gain, sexual dysfunction (including PSSD)—and speculates on broader societal impacts such as reduced productivity, creativity, and even potential links to declining marriage rates. A news segment follows, covering leaked Meta internal communications about employee keystroke monitoring to train AI models, the ethical concerns of using workers’ data, and the broader question of whether other big‑tech firms are doing the same. The hosts debate the political fallout of a cancelled Trump executive order that would have required pre‑release government review of frontier AI models, exploring the competing pressures from tech CEOs, regulators, and the intelligence community. The discussion moves to AI regulation strategies—post‑incident litigation, industry self‑regulation (rating systems akin to MPAA), and federal/state legislation—while also addressing the looming job‑displacement crisis as AI automates roles from middle management to drivers. They propose a “robot‑hour equals human‑hour” metric to pace deployment. Later, the conversation touches on venture‑capital dynamics, highlighting nepotism concerns in a startup (Lulule AI) allegedly funded due to a founder’s powerful private‑equity family, and the rigorous diligence required by VCs. The episode closes with a cultural aside about Christopher Nolan’s refusal to use email or smartphones, the challenges of a QR‑code‑driven world, and a brief consumer‑product comparison of pod coffee systems versus traditional brewing, illustrating the broader theme of technology adoption versus simplicity. Throughout, the hosts intersperse sponsor reads and personal anecdotes, maintaining a conversational yet analytical tone.

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