In this video Dr. Diane Mueller, a chronic‑illness specialist, evaluates hygromycin A, a newly marketed antibiotic for Lyme disease. She explains that the drug’s high selectivity may spare the patient’s microbiome compared with broader‑spectrum agents like doxycycline, and researchers hypothesize a lower chance of inducing antibiotic‑resistant Borrelia. However, she cautions that this same selectivity means hygromycin A likely does not treat common Lyme co‑infections, and there is limited data on its ability to eradicate persister or dormant forms of the spirochete. Dr. Mueller highlights the uncertainty around long‑term resistance development and efficacy against various Borrelia morphologies, noting that existing studies are sparse. She contrasts this with herbal options such as Cryptolepis, which she cites as having strong activity against persister cells. The video concludes with a call to subscribe, a promise to post study links in the show notes, and promotion of her clinical practice and online education program for chronic‑illness patients.
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Hey everybody, Dr. Diane Mueller, chronic illness expert here talking today about hygromycin A, which is one of the new antibiotics on the market for the treatment of Lyme disease. So let's talk about the pros and cons. So one of the pros is this particular antibiotic does appear to be extremely selective for Lyme disease, which this means that it is likely that the microbiome of the body is more spared when using this antibiotic as compared to other antibiotics on the market. In addition, we see that one of the cons is that because it's so selective, you're not going to get some of that overlapping, say, effectiveness that you do with antibiotics like doxycycline, where you see a medication that is actually treating Lyme and co-infections. Because hydromycin A is released selective, it will likely just be attacking Lyme and Lyme only. Now, that being said, another concern I have about this is right now what the thought is on this is that it is more— is less likely— this is what researchers are theorizing— is that it's less likely to create a resistant form of Lyme, right? Many antibiotics, what we've seen over the years, is that they will create this antibiotic-resistant form of Lyme and the antibiotics won't fully work.. Now what we see with hygromycin A is that is less likely to happen in the current studies. But the problem is this is a little bit of an unknown, right? Because we've said that before and this is a new medication and we don't have that much data yet. So while that's what researchers are theorizing, the proof is still needing to come out for sure if that is true or if we're going to be kind of duped like we have been with other antibiotics. We think that for a while and we realize, oh, their antibiotic resistance can occur. Now, the other unknown for me when I look at studies on this is, is it truly effective? Again, it's those persister cells, those dormant cells. We see that doxycycline, for example, as well as other antibiotics, can do this thing where it will kill the S, that's the active form of Lyme, and it will create the situation where the Lyme then more easily morphs into dormant persisters. Persister forms. So people feel— well, many cases feel better initially, but they'll have either post-Lyme syndrome or they will have reactivation and recurrence later because of those persister forms. Now we see amazing herbs like, like Cryptolepis, for example, which outperforms drugs on the market as far as getting to those persister cells. So an unknown for me with this antibiotic right now, and I don't see good studies on the morphologies coming out is, will this medication be able to get to all these different morphologies of Lyme? Will it be able to prevent the persister cells from forming? Will it be able to kill the persister cells of Lyme that are already formed? So these are all kind of unknowns right now that I just want everybody thinking about if they're thinking about using this particular medication. So please do subscribe to my channel if this has been helpful. I'm going to put a couple studies in the show notes for you. As well as information on working with me, working in my practice. I have an online education program where I teach you all of this kind of stuff and more about chronic illness, what you need to be educated on to take to your doctor to heal, to get your life back, and to get out of this, this chronic illness cycle. All right everybody, I'll see you in another video.
