You Might Have CIRS And Not Even Know It

Dr. Diane Mueller explains CIRS as a collection of inflammatory symptoms, not a single diagnosis, driven by overlapping causes like mold, Lyme disease, EBV, and gut dysbiosis. Lab markers include elevated MMP-9, TGF-β1, and C4a. She recommends identifying all root causes and using peptide therapies like VIP to reset lingering inflammation.
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Hey everybody, Dr. Diane Mueller, chronic illness expert here, talking today about CIRS, C-I-R-S, what causes it and what you can do about it. So one of the things that sometimes happens when people start looking at CIRS, which stands for chronic inflammatory response syndrome, is that many times people can get confused and think that this is like the final diagnosis. Just kind of like it sounds, like chronic inflammatory response. What's happening is the— something is triggering the body into this chronic inflammation. Now, anytime we use the word syndrome in medicine, like chronic inflammatory response syndrome, a syndrome is a collection of symptoms without a specific disease necessarily or cause associated with it. So irritable bowel syndrome is another example of this, right? So with irritable bowel syndrome, we tend to have these digestive disorders, these digestive problems that lab testing has not been able to figure out the reason why. So it's this— all these symptoms, and they look a certain way. It's happening in the gut, oftentimes comes with things like constipation and diarrhea and bloating. And so we use the word syndrome when it's like in medicine, it's like, well, I don't know. So I encourage you to consider CIRS, chronic inflammatory response syndrome, as part of the mechanism of what's happening in your body with this inflammation, but it's not the end-all be-all. So common markers that we see elevated in chronic inflammatory response syndrome are things like MMP-9, TGF-beta 1, right? These are common things we can see changes in. C4a, C3a, 3A. These types of things will elevate in the CIRS situation. Now, what is important to understand is what is behind it. What is that root cause? What are those root causes? And anybody that has this chronic inflammatory scenario, there are probably more than one root cause. So this is where we get into our toxins. This is where we get into our stealth pathogens. And if you have a true CIRS type of situation, usually you're going to see a wide variety of, of problems, right? Headaches, migraines, chronic fatigue, fibromyalgia, neurological problems, right? POTS, on and on and on and on, because the body's so inflamed. And so in these scenarios, another problem people can get into is finding one root cause, right? Figuring out like, oh my gosh, I have chronic EBV, for example. I talked about EBV in the last video. And when we have chronic, you know, these chronic situations, we find a root cause. It's so easy to latch onto that root cause and be like, this is what is causing my problem. And what I would encourage you is to look at this as this is likely part of what's causing my problem. Because oftentimes we find a root cause. Many times what happens is we stop looking for more and we start saying like, but I know I have this and this is so related to all my symptoms. So now all of my treatment is going to be around this one thing. And this is where people can go from person to person, doctor to doctor, looking for the perfect treatment for, in this example, the EBV. And if EBV is positive, and sometimes if it's not positive, it is highly likely it's a piece of the puzzle. But most typically when we have this widespread inflammation, We have multiple things leading to the inflammatory response. That's why the symptoms are so big. That's why the inflammation response is so big, because we have so many different things in the body, so many different imbalances that are actually triggering that inflammation to occur. So this is where we want to consider Lyme, Bartonella, Babesia, right? We want to consider the Lone Star tick, which can give that meat allergy. We want to consider other things like environmental toxins, mold toxins, right? We want to consider our glyphosates, which come from our genetically modified world. So all of these things— toxic metals, hidden parasites, other problems in the gut, and more— can all lead to the series of the, the response of the body to elicit something like the chronic inflammatory response syndrome. So that's what's happening there. We really do want to consider, like I said, all of these different root causes. And a lot of getting people out of this is by getting to the root. Now, for some people, one of the things that I've seen, one of the things that I know a lot of my colleagues have seen, is that once we get to the root, sometimes there's something else that needs to happen to get the body out of inflammation, right? So we get to the root, but the body oftentimes is still inflamed. And so sometimes we need a secondary thing that is going to take the body out of that inflammation and, and kind of reset the cycle. So we want to get to the root, but sometimes that, that little bit of inflammation that can still be major in symptoms needs to be repaired. For example, some MRI studies have looked and shown that the brain oftentimes in mold patients can be inflamed, that certain parts of the brain are inflamed. And what studies have also shown is that when somebody takes VIP, vasoactive inhibitory peptide, which is a protein molecule, you can get compounded, and then repeat MRI studies are done, that, that brain, the inflammation oftentimes comes down. I've seen really good results in inflammation also with a peptide called KPV. I've seen that also help with things like histamine intolerance. So we just want to consider all of these things as possible reasons and as possible solutions if we're in that CIRS, you know, situation. So, you know, one of the points of this video is just to help you that if you have this, like so many times people are like, oh, this is what it is, this is what it is, this is what it is, but it's still not hugely actionable until we know what's causing it. What is causing the immune system to inflame? So yes, that diagnosis like that can be incredibly helpful, can set the mind at ease, and so many things. But we still want to make sure that we are looking for all the reasons why. Remember, I can help you. My team can help you. If you need any of that, please do find out how to work with us in the show notes below. I'm Dr. Diane Mueller Mueller. I'll see you next time.
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