In this video Dr. Dino Prato, NMD, explains how cancer cells exploit a “platelet cloaking” mechanism—wrapping themselves in platelets and fibrin to evade immune detection and facilitate metastasis. He cites a 2025 Nature study showing that platelet‑derived thromboxane A2 suppresses T‑cell activity, and that low‑dose (baby) aspirin blocks COX‑1 in platelets, reducing thromboxane A2 production and improving immune visibility of circulating tumor cells. Prato adds that the natural flavonoid apigenin (mis‑named apogenin) can further dampen platelet stickiness and signaling, creating a two‑pronged approach. He expands on integrative anti‑coagulant strategies used in his practice—nanokinase, lumbrokinase (earthworm enzyme), heparin, ozone therapy, and other fibrinolytic enzymes—to thin hypercoagulable blood, dissolve fibrin nets, and disrupt platelet‑mediated protection of cancer cells. Clinical observations from dark‑field microscopy of patient blood illustrate the presence of fibrin webs and their reduction after these interventions. Prato emphasizes that while these measures can help slow metastasis, they must be managed by a physician due to bleeding risks and the need for clotting cascade testing. The video concludes with practical take‑aways, safety cautions, and a call for patients to discuss these options with their oncologists.
Chapters
What if I told you cancer has a travel hack, Not a new mutation, not a new chemo drug, but a blood thickening trick. Cancer cells can wrap themselves in platelets, like putting on a disguise, so your immune system can't recognize them. I like to call this the invisible cloak. And yes, many patients with advanced cancers also have what we like to call thick blood. We've seen this over the years in integrative medicine. Hypercoagulation, hyperviscosity, just thick blood giving the cancer patient higher risk of metastases, heart attack, strokes. And this is very common in advance cancer patients. So here's the good news today. In this episode, I'm going to explain to you how to unmask that traveler and get those cancer cells seen by the immune system and to help slow down metastasis. And we're going to give you some practical tools so you can put this to use. There's a great study that came out in 2025 that kind of brought this all to the surface on how a baby aspirin can help stop the platelet cloaking and help the cancer cell get more visible and the immune system going. And we can make that even better with tools like apogenin integrative agents that can work along with the baby aspirin to give you a one, two punch. But we're going to go way bey integrative care that we've been using for years that can also help you with blood clotting and anything related to that. So this is an exciting episode, and I'm glad you're joining me. I'm Dr. Dino Prado, founder of envita medical centers. For the last 25 years, we've worked with difficult, complex cancers, patients who fail some of the top hospitals across the country. And one of the things we've seen over and over again, high platelet, high fibrinogen, sticky blood, patients that are prone to clots. And this is very common in cancer patients and something you rarely hear talked about. So for many years, I used to look at patients blood under a dark field microscope. And what I saw over and over again with cancer patients is a lot of fibrin. So think of these red blood cells with all of these webs connecting them, stopping them from moving around. And when patients took different treatments, I would see the fibrin go away. So if they were, let's say, on warfarin, a blood thinner, or they were on a little baby aspirin, I would see the fibrin go away for a little bit of time. But I Would see it go further away. When we started adding enzymes and started using ozone therapy with heparin, in our clinical experience, the fibrin was so much better. And the whole reason we want to do this Is because we want the immune system to be able to recognize these cancer cells. Remember, the immune system is your first and last defense against cancer. So if we can remove this invisible cloak of all of these platelets and make those cancer cells visible to your immune system, you're going to have a better chance of slowing down metastases in any stage of cancer. So don't start just adding these things, because blood thinning can be very dangerous if you overdo it. So make sure you're always working with a doctor before you add anything that affects your blood clotting, Especially if you're already on a blood thinner or you're about to go into surgery. So please check with a doct, make sure you're getting testing so you don't overdo it. But, yes, we want to thin the blood if you have cancer. And there's a way to do that because it can help boost the immune system and slow down metastases. So let's make it simple. Your bloodstream is like a fast freeway. Cancer cells can escape from their tumors, and they can get to other parts of the body. We call these circulating tumor cells. So think of a ball of cells that is a tumor. That circulating tumor cell escapes, and it can go to other organs. If those circulating tumor cells go up, that often means cancer spreading. And if they go down, it means your treatment is doing a good job. And these are leading. We see way before tumor markers and imaging. So often circulating tumor cell changes show up Way before we see new growths or changes in scans. So it's a great leading indicator. Now, here's where the travel hack comes in. Platelets can stick onto these tumor cells, and they can act like bodyguards and help the cancer cells survive and let them hide or evade your immune system, creating metastases. Because thick blood also impacts messaging and growth factors. So when people say my blood is thick, what they often mean is the body is shifting into a pro clot, pro plat, and pro metastatic state. And that's the state that can be linked to worst outcomes. Fast growth, not because the blood is magic, but because it helps cancer cells hide from your immune system and travel to other parts of the body and set up and metastasize. So now here's where it gets really important, and why we're talking about this today Is because of A recent study in 2025 that everybody likes to cite. Platelets release a chemical signal called Thromboxane A2. It's a signal that can hit your immune system, especially your T cells, and act like a break. It can reduce T attack. So cancer isn't just hiding behind platelets. It may also be using the platelets to help cancer cells evade the immune system. That's why this matters so much. If you could reduce the cloaking or the clotting or the fibrin, you can help your immune system work better against the cancer. And in that 2025 paper from Nature, it was just a simple tool. A baby aspirin. Patients were taking a baby aspirin. And you can improve on that baby aspirin if you take a natural agent, which we'll go into here in a moment called apogenic. And I'm going to show you some other integrative agents that even take it to the next level. The baby aspirin seems to do job. You don't need a high dose because the baby aspirin targets platelets in a very specific way. It goes after COX1 inhibitors in the platelets. And that matters because COX1 is part of a pathway that helps the platelets make thromboxane A2. So here's a simple chain reaction. Baby aspirin blocks COX1, platelets make less thromboxane A2. The immune break signal drops and T cells now or your immune system can function better to killing the cancer. And here's the key point. Baby aspirin doesn't need to shrink a giant tumor, but it may help most when cancer is tiny, trying to travel and metastasize. When it's trying to spread. A low dose aspirin may help slow the progression and spread of certain cancers, including colon, pancreatic, breast, head and neck, lung and others. This effect is thought to be achieved in three main mechanisms. It reduces inflammation, inhibiting platelet activity and blocking cancer promoting genes. Now let's add the missing piece that most people never talk about. Apogenin. So apogenin is a natural compound found in foods like parsley and celery. We've been using it for many years in integrative medicine and very common with our patients. And it has very interesting role in platelet biology. Here's the easiest way to understand it. A baby aspirin helps reduce the signal production from the platelets. And apogen can help reduce the signal action and the platelet stickiness in another way. So the baby aspirin turns down the signal maker. And the apogenin Helps calm the signal effects. And that matters because platelets cloak in both chemical signaling and physical stickiness. So when you combine these two combinations, that's pretty easy for people to get access to. You can do this biohack in oncology. But let's take this to another level. An integrated medicine. We've been talking about thick blood with cancer patients for decades. It isn't new. This has been going around forever. Hypocoagulation, sticky blood, clotting tendencies. And we've known for years it's linked to inflammation and the spread of cancer and giving cancer patients risk, like heart attacks and strokes from thick blood. This thick blood drives inflammation, supports metastases, and this immune escape. That's why in integrative care, we use things like enzymes, Things like nanokinase, which has been around forever and very powerful. It would be a patentable drug, but it's a food and it has incredible blood thinning capacity. On fibrin, lumbrokinase, which I'll go into here in a minute, which is made from the earthworm. So we've used all these enzymes. And like I mentioned earlier, When I look at patients blood under a microscope, Is when I saw that they were on ozone therapy with heparin, which is another blood thinner, and on enzymatic therapy that we would give them, and we do commonly with our patients, that this fibrin was like, not there and it was gone. And it was holding beautifully on the slide of the microscope. And when we gave patients aspirin, it only worked temporarily. So just to give you an idea, There are many ways to approach this anti metastatic approach. Approach with the cloaking of these cancer cells with platelets. The idea is not just to thin the blood. The idea is to remove the shield. That's the traveling advantage for these cancer cells, to just remove their cloak so the immune system can see them. Because these traveling cancer cells can often get masked by this fibrin. So moving through the body unprotected, not allowing the immune system to do their work. Lumbrokinase from the earthworm Inhibits cancers through multiple pathways. It can induce apoptosis, Programmed cell death in literature, Inhibits proliferation, the metastasis and the spread, slowing the growth. And it can target, like we just talked about, and fight chemo resistance. Heparin, like I just mentioned earlier, is a potent anti cancer agent, Primarily known as an anticoagulant and used in integrative adjuvant therapies along ozone and other oxygen. Therapies Heparin demonstrates a significant anti cancer effect. It works by actively blocking metastases and hindering tumor growth through several mechanisms inhibiting cell adhesion. They're trying to stick it targets and blocks P selectin interfering with invasion. It disrupts blood vessel formation and interferes with angiogenesis when tumors are trying grow new blood supply. So we want to break all of that and that's what this allows us to do. So here's the clean takeaway. Cancer can travel and the platelets can help it hide. But this 2025 study shows that baby aspirin can reduce key platelet signaling tied to immune shutdown, especially around Thromboxane A2 and when you add apogenin and even more importantly these integrative agents. As you're under the care of a doctor, you're going to be layering in care that stops metastatic spread, at least from this platelet cloak. Reduce the stickiness and the signaling that happens with thick blood. And that's something every cancer patient should be looking at. But I'm going to say it again, do not make these changes on your own because you don't want to over thin your blood. Make sure you're getting tested and you're under the care of a doctor. I hope this was helpful. And ask your doctor about what you're doing related to some of these techniques to reduce metastases. Can you block these platelet formations and fibrinogen and reduce this risk? Clotting. That's a good protective strategy and something everybody can add to their plan. It's also something that can be tested for as well. If we look at these levels using clotting cascades, which we do in our practice and of course it's a more advanced test, but you can look at the clotting cascade and affect it at a higher or lower level which impacts this fibrin and it impacts sticky blood and thick blood which you want to stay away from when you have cancer. If you found this message helpful, please share it with other people so they have options and understand more about precision oncology and not always stuck to the one size fits all model. I hope this was helpful and may the Lord bless you on your journey to healing. Bump.
