Cancer Patients Are Choosing This Instead of Surgery Now

What if the future of cancer treatment isn't another strong radiation beam but sound waves? You heard me correct. Sound waves that are customized with immunotherapy. Because here's the difference. A tumor isn't just a lump of mutating cells. It's loaded with data. It has all the information your immune system needs like a fingerprint to go after cancer in other parts of the body. And most cancer treatment ignores this completely. But what if we could break the tumor apart without heat, without destroying it, without cutting it out, without radia it and then get the information from within the tumor and then use that to build an immunotherapy? That's what we're going to be talking about today is training the immune system using new technology so your immune system can go out, find the cancer and help the body eliminate the disease. We like to call this on our team Symphonics. It's the use of sound waves like a symphony Symphonics to kill cancer cells and build a customized immunotherapy. It's exciting technology and I believe this will also help in changing the world of cancer. Providing more solutions and less need for surgery or radiat and getting directed tumors and killing them quickly with a mechanical movement of sound waves which is really powerful. This is going to help us turn on the immune system and go after cancer in many different ways. I'm Dr. Dino Prado, founder of Envita Medical centers. For the last 25 years, my team and I have worked to help thousands of patients who have failed the top cancer hospitals across the country with precision targeting. The goal here is to help explain technology that's not in standard of care, that's more precise using advanced immunotherapies to help patients outperform and get their quality of life. So what I'm sharing with you is not just a published paper. This is from clinical experience. So from our experience of two and a half decades of working with patients. This is for educational purposes only. Make sure you're working with a doctor before you change any of your healthcare. So let's get started. Here's the truth most people don't hear A lot of Cancer treatment is great at local control, meaning it can shrink a tumor maybe a little bit, but it doesn't have that long term response we want. Otherwise people would go into remission and stay there. But cancer often wins because it becomes resistant or what we call refractory to care. The immune system doesn't recognize it, the treatments stop working and patients die. That's what we want to change. We Want to change that entire picture with using precision. So one of the interesting things that happens when we kill a tumor is we get lots of information. The tumor is a library of data. It has neoantigens, it has tumor fragment proteins, Immune modulatory data that when given to your dendritic cells, natural killer cells, T cells, et cetera, they can play an enormous part of this concert. So why we call it symphonics is because first we use the ultrasound to liquefy the t, kill it. And we use a special type of ultrasound. We don't use heat. We're using the mechanical movement of the waves. And then we use the lysate, which is the liquid in between, if you will, to build immunotherapy care. So it has a systemic effect throughout the body. Symphonics is designed to exploit this part of the immune system and do it in a very elegant way. And it's using the sound waves to kill the cancer quickly. But we need to get one thing clear. Ultrasound is not just one thing. There's a spectrum of these sound waves. There's ultrasound that uses heat, like we saw with hifu, which is a thermo ultrasound. It's been for a long time and used to treat different types of cancers, but it does it through heat and burning. And so the material left over in a hifu may not be as useful as the type of ultrasound that I'm talking about here. So when you use heat or temperature to ablate a tumor, it can pretty much destroy all of the information for the immune system, and it can kill the cancer, but not maybe have that information that we want to use for the rest of the body. It's like frying an egg. We've denatured the proteins, the information, the neoantigens, so they may not relate very well when we're talking about spreading that information other parts of the immune. But now with histotripsy, we have new mechanical ultrasound potential. It's very different. It's not cooking the tumor. It uses a bubble, powdered mechanical destruction. It's like a cavitation, Tiny bubbles forming and collapsing and physically breaking apart the tissue of the tumor in precision, where it spares the healthy tissue. And in there, we get this acellular debris that's fluid, like, called the lysate. And that material is really powerful. When the ultrasound is used, it spares collagen, blood vessels, and a lot of other ducts. So it's very precise in just killing the cancer. I like to use the analogy here of the easter eggs that we See where you have the chocolate on the outside and you have the liquid in the middle. And the idea is when you look at the lysate, it liquefies the center of it so it's almost like an egg. The middle of it is liquid. The outside of the shell is the tumor. It's all killed. And now we have this information we can use. So in the Symphonics program that our team is working on, the goal is immunotherapy synergy. Before we even begin the use of ultrasound, we use deep testing to look at the tumor. All the resistant. So not just biomarkers in DNA, we look at RNA transcriptomics, immune profiling and spatial biology. So we can look at 1000 plus markers and then look at the resistance. So if we see for example, cancer stem cells, which are very common and they can make cancers very hard to kill because it'll return over and over again. Now we can use nanoparticle phytotherapeutics direct to the tumor prior to the use of the ultrasound with the goal of killing the cancer stem cells and now having a very rich lysate or collecting that debris and using it in other parts of the body to st stimulate the immune system, even other tumors. So that's the excitement behind histotripsy and actually using it with targeted sonodynamic agents. These are agents that make the therapies work better, these phytotherapeutics that are nanoparticles that enhance the mechanism of the ultrasound. This is really kind of exciting because now we can take that fragmented part of the tumor, the liquid, and use it to build the immune system. In October 2023, the US FDA authorized the marketing of Histonics, an Edison system for non invasive destruction of liver tumors. So it' just approved for liver cancers at the moment, but it's coming for many others. There's applicators for breast and other tissues, so it will be used in other parts of the body. At the moment, it is approved for the liver on label and there's off label usages as well. The process here creates a cavitation and it's important because that's the first authorization. With devices and drugs, you often get one authorization and you slowly work on expanding its platform. But the reason it will not explode in hospitals is it doesn't bill as high as their other procedures and they'll only use it in liver when other treatments fail. Only hospital hospitals will use it in that way because they can bill higher than standing clinics. Standing clinics bill far less because insurance Reimburses far less than they reimburse through the exact same procedure to a hospital. And this is important because if you understand the cancer industrial complex, it's one of the reasons we don't get the latest technologies to patients. We're not able to advance them very quickly. And it slows down access to care that can be life saving. And it goes back to having the right billing codes and reimbursement rates and the investments that they make. But in the original studies with histonics, they found some pretty interesting things. Histotripsy a way was groundbreaking because it's non invasive, didn't use temperature to heat up the tumor. It used an ultrasound technology that uses acoustic cavitation micro bubbles to mechanically liquefy liver tumors. This was important in their initial studies. They used primary liver cancers as their first group or metastatic liver tumors. And they treated these populations. They made sure the tumors were larger than 3 cm in size and they treated the patients. And the patients that were eligible got the care. And what they found in the benefits of the trial was the performance was fantastic. They had 95% success rates on these tumors. They successfully treated or ablated, another word for killing or removing those tumors without using radiation frequency and just using the sound. Histotripsy doesn't use x ray. It uses like a heat sink effect in the area and prevents a full destruction and avoids radiation damage. So it's another wonderful tool in precision oncology. It provides a mechanical action of selectively killing the cancer and sparing healthy tissue, collagen, blood vessels, bile ducts. So it becomes really, really interesting. Imagine here, I'm going to just walk you through an example. Someone has a colon cancer, they get an ultrasound, the tumor's dead, it's gone. No need for surgery, no need for real high dose chemotherapy. Now that you have killed the tumor, you can extract the lysate from the center of the tumor, which is now the immune information, and with other immune primers or adjuvants, use it to stimulate the body's immune system to recognize the cancer cells anywhere in the body and keep the body with the goal of having long term remission. So that's powerful. And in that initial study, they didn't find people that had major complic, there's less, less than 7%. And the reason that's important is because when people have liver disease or metastases of liver, usually disease is pretty advanced, it's a later stage disease. And so they've had some very good results with it. And the technology's only get better. So what we're going to see is I think a far bigger growth in this ultrasound technology. What was also interesting is you have a lot of billionaires dropping money into this technology. Bezos, Peter Thiel, all these big dollars because they see how disruptive it could be in changing the way we treat cancer. Moving away from radiation and surgery using ultrasound, much easier, cleaner, better of life. And what we're talking about here in precision oncology is taking it a step further by building an immunotherapy right from the same treatment at the same time. So now the patient has a systemic effect not just at the tumor, but throughout their body. That would be the goal of the treatment. So let's make it simple so you can understand it. You break open the tumor cells and you get a mixture of tumor proteins, DNA, RNA fragments, neoantigens, these new markers, immune alarm system signalings, and a mixture of this, all called a tumor lysis. That's after the ultrasound treats it. And now you use that to stimulate with immune adjuvant agents in the body to go out and say, here's what the cancer looks like. Go out and find it and don't let it grow back. And then you use phytotherapeutics to increase T memory cells. So now your immune system can recognize this particular cancer in the body and go after it, aiming for a long term positive response. So that's pretty important. And here's where it gets exciting. When a cancer cell dies, the immune system can feel this information that gets released. Like we talk about the damage associated molecular patterns. These dams are flares that tell the immune system to go after the tumor. Well, if this is under a controlled mechanism, you get a kill, you get a release of dams with immune adjuvants. And now you have this lysate which is telling all the T cells, natural killer cells, dendritic cells, what to do with the information. And that's the power of technology moving in. Cancer treatment, so we call it Symphonic symphony isn't only about tumor destruction, but it's about creating an immune moment where the body knows what to do with the goal of long term outcome. Not just managing the cancer, but killing the cancer. In fact, I'll link an episode below so you can see the difference between managing cancers and killing cancers. It's very different. Most of the treatment that's out there today in late stage diseases, to manage it here we're talking about eliminating it. So it's important because now we're creating an In Sit 2 vaccine at the level of the tumor almost becomes information for the rest of your immune system to eradicate the cancer cells from your body. Remember what's so powerful about this using histotripsy and then combining it with this immunotherapy is that it's your information. It's not from some double blind placebo, clinical trial, population health drug that's sold to everybody. The one size fits. All this is customized onto you. So the material that is in your tumor, your cancer, is used to help your body eradicate it, which is brilliant and that's what I love about it. It's an N of one custom made for each individual patient based on their tumor information and then the vaccine is developed within their body. And in fact that's the way our body normally and naturally eliminates cancer. So what can we take from this information? Some of the questions we may want to ask our doct because this technology is pretty forward and not available everywhere by any means and it's going to take a while to get out there. But let's talk about this. So if you're at your doctor's office you can say are we using immunotherapy? Are you getting direct to tumor? Have you done full testing, not just DNA biomarkers which people talk about, but have you done full RNA transcriptomics, immune profiling and spatial biology to look at my tumor? Are we going direct to my tumor and do we have a strategy to turn my immune system on to fight the cancer throughout my entire body? That's what you want because that's the goal of tools like Symphonics where we're using, using ultrasound and immunotherapy to teach the body what it needs to do because that's what the body does naturally. The immune system can see about 10,000 pre cancerous cells every day and delete them with the right information. And so this is giving the right information to the body with the goal of eliminating the cancer long term. So this lysate is very special, this liquid because it's not burned, it's got full signature data and it can be used to treat the immune system. And we're already seeing that has been done in animal studies and now being done in brain cancers and moving forward in other types of cancer treat treatment, which is super exciting. Is this liquid information helping us to build a strong immune system. So this is powerful. I hope you found this episode exciting and helping you to learn more about how we're moving away from radiation and surgery if possible and using quick procedures like sound to kill a tumor and then using the information to build the immune system with other adjuvant immune modulators to help the body respond best. This is so important because it can change the game of an entire patient dealing with so many cancers that today are cold, not hot. The immune system isn't working. There's so much surgery might be in involved and trying this or that chemotherapy, trying to qualify for this or that clinical trial instead of actually just saying I'm going to use my own tumor information to build my own treatment so that my body knows what to do and how to heal itself. And then if other immunotherapies are needed, like PD1 inhibitors or on and off label adjuvants, they can be added based on your immune profiling and spatial biology. That's the power. So I want to thank you for joining me now. If you found this episode helpful, please subscribe. Because you're subscribing helps us, not just the channel, helps us to get the word out on precision on coffee that people around the world the way the YouTube algorithm works is the more you subscribe and comment, the more it pushes it out. And now we can really help people learn more about precision oncology so they're not stuck in the one size fits all model that's both doctors and patients. The more we talk about these strategies and discuss them, we change the way people think and we start to open up the door for precision oncology to save more lives and extend lives. Because technology is moving quickly, but people don't have access to it. And my goal is for people to learn and to think and understand how to combine some of the most advanced technology in the world to change cancer outcomes. May the Lord bless you on your journey to healing.