Mebendazole, a cheap antiparasitic drug, disrupts microtubules the same way chemotherapy does, stopping cancer cells from dividing. It's already FDA-approved and safe, making it a potential low-cost cancer treatment waiting to be tested.
What if something simple like a dewormer drug that costs less than a cup of coffee could disrupt the same pathways that some chemotherapy drugs do? Menbendazole it is a microtubule disruptor. Cancer cells rely on microtubules. These tiny structural tracks to divide. Menbendazole interferes with these tracks. The crucial question is whether the mechanism of action aligns with your specific targets. Menbendazole was FDA approved and it has a safety profile as an anti parasitic. But that's not why we mainly use cancer. So these microtubule disruptors work on microtubule depolymerization and stopping this way that cancer cells divide and spread, similar to drugs like taxanes that have been around for a long time. Vinca alkaloid drugs.
