What's NEXT for PROSTATE Health Beyond PSA Testing?

6 Dec 2025 · 18 min
18:05

In this comprehensive presentation, Dr. Dino Prado critiques the reliance on PSA alone for prostate cancer detection, highlighting its susceptibility to false positives from benign conditions, lifestyle factors, and normal aging. He identifies metabolic syndrome and chronic insulin resistance as the primary root cause of prostate enlargement and cancer, arguing that addressing insulin, inflammation, and visceral fat is essential. Prado outlines a multi‑layered prevention and treatment framework: (1) lifestyle interventions such as intermittent fasting, low‑refined‑carbohydrate diets, high‑quality protein, and antioxidant‑rich foods (especially lycopene‑rich tomatoes); (2) targeted supplements—including saw palmetto, EGCG, melatonin, beta‑glucans, vitamin D, zinc, and natural aromatase inhibitors—to modulate hormones and inflammation; (3) advanced screening beyond PSA, featuring the European PSE test, multi‑cancer blood‑based early detection panels, mpMRI, PET, circulating tumor cell analysis, and methylation scoring; (4) precision therapy using 3D cone‑beam image‑guided intravascular immunotherapy that delivers localized treatment while preserving immune function; (5) deep molecular profiling (NGS, RNA transcriptomics, spatial biology) to map tumor evolution and immune landscape; and (6) continuous monitoring with wearable devices tracking glucose, blood pressure, heart rate variability, and sleep. Throughout, Prado emphasizes avoiding overtreatment such as radical prostatectomy, advocating a personalized, data‑driven approach that integrates diet, lifestyle, supplements, cutting‑edge diagnostics, and targeted therapy to prevent and manage prostate disease while supporting overall metabolic health.

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