COVID HELP by Dr Kiran Dintyala

Talk to people every day. Explain them what is going on with COVID and how not to worry about it. And how to take the right action, right decisions in getting their Covid treatment done. Okay. Now today we have hematologist and oncologist Dr. Appal Naidu who is also my classmate from Andhra Medical College who he's currently here in America practicing medicine. So he's here today to help us answer some questions. Educate us about COVID treatments. One of the latest treatments that we are seeing is the monoclonal antibody cocktail. So what is this monoclonal antibody cocktail? That is what we need to figure out. So let us without wasting any more time let's have Dr. Apple Naidu talk to you about antibody cocktail that everyone is curious about.

Yeah. So thank you Kiran for the introduction. Yeah. Basically I will talk mostly in Telugu but understand. Kanye. As Dr. Karen said Covid treatment Cosmox approval. Remember medicinal. Main effect. And the management of part of it. That is the treatment for Covid and Chapel. So in general technology, Various drugs, various measles. As Dr. Kiran always say there are only few treatment options which would work and. Treatment which they know. Otherwise I'm fine. But you know what? No it doesn't work that way. Other than that inflammatory phase already infection. Various chemicals to release like a war. Chopped head, chopper limbs. I will feel bad. Until that means like you know body virus. Part of that is this destruction. Collateral damage. Various organs damage. So doctors tells oxygen levels. So that's one treatment option which is proven to be beneficial in terms of you know like you know treatment. So don't ever use it. Okay so choose finally latest at least India monoclonal antibodies. Okay so US will approve on the first approval us. Next to three months later February low inco company drug approved company there. So we'll talk about that in specific cocktail. And cocktail is nothing but you know bro Milo alcohol. Okay. So next to. So mood different companies Ninji every three months on average different drugs, antibodies, monoclonal antibodies. India I think second week of May law regional and company and India partner I think Roche. Roche our company basically I mean the company. Second week of May law Indian government to you know drug control society. First thing is monoclonal antibodies. So allocations from Thai. So timing is important. Okay. Preparation important too. So okay. Monoclonal antibodies in general. Monoclonal antibodies and the monoclonality more like a medical dermati and Waka clone Ninji. Waka type of cell Ninji antibodies produce. It's like a mother cell. To lack. Various technology beyond our scope of the discussion. I think most of us know what is antibodies. Antibodies basic fight Chase type of proteins and Kundi. Okay. Antibodies normal Gala produce infection. Common cold virus. They will get over it and eventually antibodies produce hypothesis infection. Okay. Polio vaccine number two. MMR vaccine number two. Appetite B vaccine number two. Like, you know, virus to lay the bacteria mimicking substance. Part of the viral particle and genetic code line. Okay. I went into the body mana cell loop at the choosy. Antibodies produce infection of chest infection. Remember, Based on science, based on technology. So I'll be antibodies. Antibodies. One of the country borders, Whatever it is. Okay. Most of the time. Serious about the issue. Okay. Other kind of antibodies. Okay. For example, vaccine. Vaccine or covaxin vaccine. Okay. Three, four weeks wait chest based on the dental value. Okay. Two, four weeks second dose antibodies production 80% of the people. Only 30 to 50% people. Depending on your age or risk factors. Etc. 2nd dose 2 weeks wait chest neutralizing antibodies and data virus antibodies produce how long it is taking? Almost four to six weeks. Six to eight weeks from first dose. Okay, so immunoclona antibodies are different. If already antibodies already lab. It's, you know, very good technology. Various technologies. Fight Chase antibodies ready to use and matter over the shelf under me IV bag there other antibodies. Diabetic patient to 70 years. For example. Warning signs. Especially, you know, weak points. Antibodies ready to use antibodies. Antibodies. Spike protein, spike protein, spike protein. Proteins. Most of our body is made of proteins. Protein body a spike protein. Key against guy antibodies. Most of the vaccines. But downside. Monoclonal antibodies good side anti. Ready. They're ready already four to six weeks. Okay. For example, you know, Six months, eight months already well trained. They're ready to fight. You know, Recruitment, recruitment. Antibodies produce six to eight weeks from the first dose. Will act for the two weeks from the second dose in Tarvata. Ready. They're ready and they have antibodies, monoclonal antibodies. They are ready packaged and mata already work. For example, 50,000. Okay. Rupees. The EEB Immunity lack of protection. It's not like a vaccine protection. The antibodies, antibodies and proteins in the especially biting GSAV body load is very different. Vaccine already continuous. Antibodies produce memory cells. Memory cells, memory.

Hey.

Antibody produces antibodies. Usually vaccine immunity. It will be a prolonged immunity. There are speculations maybe six months vaccine immunity maybe maximum 12 months. Maybe across the world every year. And probably we need a bolster all of us. You know, like every Europe booster, which is okay. Next is no flu shot. Scientists look. Number variants of Chest. Technology changes chase so going back to monoclonal antibodies. So the antibodies ready to use ovat. Okay. Millions of doses of heroes. Okay. Already wax virus spike protein. 4 million people most of them will go into our country. Let's say my patient cancer patient to 55 years. 65 years. Code passed test positive operating 65 years cancer patient immune system already down. Okay. Symptoms develop like a vaccine ready made ready to produce antibodies. A virus already enter body patient virus antibody saying as the anti willy antigens under antigen center nothing but a virus on a spike Protein and matter antigen antibody. Okay. Virus. Antibody antigen antibody antigen and the coronavirus aspect protein. I think we need to take care of this trash can or remove.

Okay.

A complement system so the anvil name of the virus Imar cell virus individual cell. Virus replication and divisions. Cel. Okay. So there is no war. Okay. Customer already virus full body most of the time by day 7 or day to virus battle damage collateral damage. Within ideally first week. More than 60. Diabetes that a very big person. Obesity person about 2. Kidney damage. Okay. So now COVID test was symptoms within one week. Ideally up to 10 days. Ideally within one week. Basically Indian version. Okay. Plus mw map cocktail and matter. Monoclonal antibody. You know scientific term you know V I am Davy map V I on the V I and viral. So virus you know technical design. But it's interesting to know. 40 year old, no risk factors, nothing. Okay. I can afford this. $70,000. 70,000 rupees. Remember cost effectiveness. Various studies. Different. Different company studies phase three and a randomized soda dependent clinical trial within a proof cover. And you know like you know, I mean. 80 to 85% mildly. Already standard of care and already approved drug placebo plus approved drug Allaga studies placebo controlled group. Placebo effect under Matalak for the bias lander blind. Various studies. Monoclonal antibody cocktail. Chest in the antibodies real antibodies hospital chance death chance decreased by 70%. Okay. It's a very significant number. 70% of for example. So data only render the timing important. Age group lok risk factors on I cancer patients.

Very good, thank you. Excellent explanation and presentation about the monoclonal antibodies by Dr. Naidu. Today he. India Pakistan army. So that's very good. In summary Chapalante Dr. Naidagar Chapindi. India Available monoclonal antibody cocktail cocktail antibodies. Okay. Virus spike protein. Different. So that virus antibodies. Early stages low virus replicate first to five days six days. Help. Age 65 above diabetes, high blood pressure, cancer, heart problems, kidney problems. Progress 80 to 85% mild disease 10 to 15% moderate diseases 5% severe diseases. Less likely for him to really progress to severe disease. We need to make sure. Okay. Yes. First five days. But biopadi. Yes, right. Naidu, if you really want to take it initially even though you are only 25. If you can afford it, there is nothing wrong with it. Okay. Mild disease maybe moderate diseases. Oxygen saturation 95% then it is good like after two and a half three weeks number one use but also study slow provendante it is actually harmful if you are giving late in the course of disease. Okay, so first one week to 10 days. First to one week to 10 days. Preferably sooner. Almost any antiviral treatment general first one week. So. Okay. And outpatient therapy. Inpatient therapy. Inpatient Hospital admit Avakunda treatment already Hospital admitter. You already pass the stage of the 10 days and you have gotten really sick. Okay, Typical. So outpatient therapy. 20 to 30 minutes. Yes everything good. Subcutaneous injection. But in essence use the medication when there is high risk to progress in Covid outpatient therapy. Anything else? I do that in summary.

Anything Kiran I think you covered. That's a good summary. So side effects. Already spike. Protein Antibodies. Serious side effects. Body pains, you know muscle pain. So injection. Major side effects. Antibodies. Cancer Law. Name me as a cancer specialist too. Almost more than 200 different monoclonal antibodies. Amalaki cancer patients. They're very very good and effective Technology Old technology Kani Mana technology Mana Scientists. Vaccines. Reading technology. Scientist. Wow, what a science. Wow, what a scientist these guys are. One more thing before I give it back to Kiran. Vaccine is the only solution to prevent another wave of or to beat this virus. Almost 63% of adults are vaccinated by at least one dose. Indian In American Independence Day July 4 and 874 Gadda 74% of Americans should get at least one dose of their vaccine JPC and pledges. I think he can do it. You know we all can do it together. Vaccine rate 3.3% okay, 3.3. We can do it. I know it's a big task. I think government sue State government vaccines import. I hate to discuss about treatment options.

100%. 100% prevention is better than cure. Prevention is better than curany. We wait until last minute. Vaccine Gurinchi Dr. Naidu Chapinetu 1 of the most important things is a monoclonal antibodies vaccine Key monoclonal antibody VI Technology. Vaccines Technology. Antibodies. So I will reiterate this point again because. Actual virus mimic chase to virus laga on the particle essentially. Okay. Adam body when it is vaccinate. That is okay. It's all important question again and again. So vaccine side effects, bad side effects, Accident. So risk managers okay. Benefit choose Kari Benefit anti vaccine. The chance for me to get a severe form of COVID is far less. Yes Exceptions Laban newspaper La Ju Samo Imaja. Okay plus aina wife. Yes Jarutai Akra but the chances are very low. Then vaccine Escondano. I am feeling much safer. And in California San Diego they have lifted the restrictions Optional mass Petco okay, so in the context virus transmission 70% of people vaccine community low automatic virus. Third wave. Positive. So. Speculation. Educated speculation. Original first last year April, May Old people, deceased people, Middle aged people. Even young people. So it goes to the middle aged people, the young people. So Maliki children Kostanda Any speculation? They should be able to fight it.

But.

It could only be 1 in 10,000 deaths. But who wants to take that risk, right? We don't want any of the kids to die. Third wave possibility Monoclonal antibodies, steroids, Remdesivir Kadu Plasma therapy. Vaccine. Vaccine is the only solution. If you don't want your kids to die. If you do not want a third wave vaccine is the only solution.

It's true. Kiran, I think you know you nailed it. So basically. Life, any life, animal life, plant life of virtue. Wild life of virtue, human life of virtue. Tennis, football. About you. Techniques, training, championship. Vulnerable people, You know, available to you. So it's beyond our discussion. Okay. And mutation. Any virus does that.

Survival of the fittest. Danny. Survival.

Exactly on the virus side. So are they praying? India. Okay. Entry docking stations. Jumping. Virus eventually will die off. Eventually they'll die off.

Maybe we need to do one special session regarding kids. Actually maybe next week if possible. Possible we can focus on. Because parents are very much worried about their kids now maybe situations they can be sheltered precautions. We are all. We all are ears to know that that's a small sincere suggestion from all the people over here.

So before plan it based on Kiran's availability.

Sure, sure.

Again to talk about it. I think kids topic is very very important. Without any doubt and next to one, two, three months we will. We need to address it again and again to different audience. So we will do that. Two, three questions.

Yeah, five questions. Three. And another two questions. Before starting the session let's go with Saikiran's question.

This is for Naidu. Is it advisable to give the same vaccine we have available to kids as well?

The short answer is yes. But let Me explain it. Remember that and otherwise. So Pfizer vaccinate starting low, you know, so and so age group. Okay. 16 plus to 18 plus. So different vaccines. People need vaccines. For example, 94 to 95% benefit. Up to the age of 12 years. And speculation by December, not too long from now, they will include kids up to the age of maybe six month old. Okay. Especially being a scientist to being a science person. I cannot say it. Okay? I want the proof. Okay. Six year old, eight year old, almost eight. Study happy study in a clinical trial. Happy. Okay, short answer is most likely it will be approved for everybody including newborns or you know, six months old or an inch usually. Okay, can it time?

Hopefully. But next question Shruti is asking sir post Covid what is the duration that black fungus can occur? Adi depends on immunity amount black fungus. Problems. Black fungus, black fungus, steroids, ICU low Novi we rarely got black fungus. Okay, India lower question. Prolonged dose of steroids used. High dose of steroids used here in India. Dexamethasone 6mg every day for 10 days. Prednisone 40mg every day for 10 days. Ghani methylpredin some 32mg daily for 10 days. Low dose steroid syndrome, Especially at the beginning of this second wave. Very high dose of steroids. Immunity the Guthundi Immunity the Gutando opportunistic infections. And now until the opportunity was on. Jose. Fungus nasal mucosa fungus spores. Okay. Plus Piga India la Maniki soil. It does fungal spores availability. All right, so Avikani immunity. High dose steroids, sugars. Diabetes out of control. Diabetes out of control. Automatic immunity. Diabetes out of control. Perfect environment create just in the fungus grow mucormycosis or any other fungus or any other infection in fact. Okay, so general ICU ventilator. The chances for you to get mucormycosis is rare. Okay? Don't worry about it. The chances for you to get is rare. Okay. The immunity then it is going to attack. I hope that answers your question. Okay, next question. Likit is asking sir, is it necessary to take blood thinner during COVID positive? Many people are suggesting to take. Want to know, sir? Nair, you want to answer it or you want me to?

So you know blood thinner? Santa, you know blood. It consists of lot of elements, a lot of cells. So proteins, you know, plasma, you know, water. So you know coffee. Love to do coffee powder milk ratio. Okay, so consistency. Quantum and blood thickness periguti flow routes to flow slow. Legs Lawy law. Stagnant Type in the name of the Allah. So avani. So anyway blood thinners very good question wakati marco testari test WhatsApp lo munch messages austini treatment options chalabon sr lack of lab test. Okay. D dimer crp cbc and even IL6 fancy test viral load. Including hrcd and high resolution ct scan.

Yeah, easy.

Wow. Wow. See. I think units are important. Units important. Type of machine Prakarmu type of technology Prakaramu lab value. Just for example. Is it too high? No. Obviously. Patients so important 25 year old, 40 year old. Almost won the message every other day the friends family. Answer is no. Okay. Can you use on the right time patients to Dr. Low Avasarambabi Chase Konapuru. Okay for example. Okay. Coaching smoke landed. Remember there is a difference. Exactly. Guy smoky like a false alarm of okay. Controlled environment. As Dr. Karen said mild 4, 5 days crp test 2 cbc test 2 ct scans useless. CRP test length, inflammation, body length inflammation, Mild elevation usually like 5 to 10 times of upper limit of normal for example. Then the serial measurements are important, Okay. You know like 18 hours a CRP off life. Okay. So going back to that blood thinner, Moderate disease, full dose severe disease prophylactic dose. Depending on your condition.

Specific situation low. So he was here before explaining the situation about his parents and himself. So it seems like for your parents and yourself you got mild disease. That is what I remember.

Yeah.

Yes.

It's been 19 days for now, sir. 19 days, right? You have mild disease and you have recovered completely. And the chances for people with mild disease to get any kind of blood clots is very, very less. Okay? Is very very less. Plus my body recovery so it is already handling everything inside. Okay. My body law so the need for blood thinner for you I do not think there's any role. I don't think there is any doctor who will definitely say that you will need the blood thinner hospitalized disease full dose blood thinner, half dose blood thinner more medical details but most people mild disease. Okay. Neoxar choose ibuprofen Ghani combi flam Ghani escunde. Medication. Okay, makes sense. 4 or 5 days part 2 viral replication phase antont just multiply our time general cd change crp change D dimer change abnormal chances mostly they will be normal abnormal. Okay. Salamandi. Initial. Virus immune system fight chest Fight chest collateral damage. Okay. Okay. Jaralinka Bhaga Peripotanai Elanti Ghanaka Upput CDS can change coach just a second week like Elanga series can jealous now okay. Double savior, Squandan. Okay. And. Education sessions. And create Chad and Jerry. That is important. I like a D dimer Gudante. So Miku first initially. Okay.

Next.

Let me see if there are any other questions.

Three questions. Two questions are similar. Either we could test forward messages. Crp, cbc.

Let me explain. Crp cbc. Okay. Sina example. Itchy. Explain. Yastan okaliki, COVID Positive achandi symptoms. Loss of smell. And the kanchan jaramandi. Maybe kanchan dagundi. Just stay at home. First week. Okay. Second week. Second week symptoms. End of second week. Symptoms. Yes, it is very reasonable to go get the test done. Cbc, crp, D dimer, ferritin, interleukin level. So no viral load change calls an Avasana level. Okay. Chest. Yes.

Same time go see a doctor as Dr. Kiran was implying. Talk to the doctor and he will order the testing and additional testing as well.

Yeah. Next, another question from Ravi Teja. After how many days a person who is recovered from COVID can go for vaccination? General two to three months. Antibodies. Okay. Immunity. Immunity. Usually three months. Sometimes even little longer. Maybe six months. So three months. You can get started on the vaccination and. Antibodies. Yes, you can take it in the next. Within a month also. That is okay. Just be ready. My body already. Antibodies, vaccination. You can get more fevers. You can get more body aches. Just be ready for it. Don't worry too much. They had these symptoms patients vaccine. So just be aware of it. Monoclonal antibody. Antibody cocktail. You should at least wait for three months. You should at least wait for three months. Okay. Antibodies. So you want to wait until make sure makes sense. And either you want to add anything else there.

No, that's perfect. I think you know, basically contraindication. Wherever. Infection. Priority. Vaccines, Immunity. Three months. Remember this at least in coronavirus. Naturally immunity. Like you know, infection immunity. Vaccine immunity. Longer.

Yes. 100%. Right. Sir, Once someone gets Covid and are unable to be admitted to the hospital due to lack of beds and facilities. What kind of measures should we take at home? Can we use steroids from an early stage of the infection?

Okay.

Okay. Definitely. It's an important point. We are going little above our regular time today. But I think this is a very important question and we will address it. And we'll end the session today after that question. Question. Okay. Hospital key. Hospital bed. Hospitalization. Avali and Eddie. Okay. 99%. 100% normal count only. Okay. Above 95% is still normal. Nothing to worry about. Are doing fine. 95% oxygen levels that we consider as moderate Hypoxia. Okay. Hypoxia 95%. A moderate disease. 80 to 85% people mild disease. Oxygen problems, difficulty breathing. They just get better. Okay, 10 to 15% people moderate diseases. Okay, 10 to 15% people moderate disease. Oxygen levels above 90% on time. Okay, it is above 90%. Even though it is below 95. It is above 90. So it is between 91 to 95. You can manage it at home for most part hospital. Okay, so what you can do at home? Doctor guidance. The general information chooses. So. Okay, Educated doctor, well known doctor. You know, doctor guidance is quite important. Okay, so anyway. Moderate hypoxia above 90%. Only oxygen levels below 95. What can you do at home? Wakati Steroids. Low dose steroids. Okay. 10 days. Inflammation. Levels automatic. Okay. 10 to 15% people they get better just with steroids. You only need steroids that you need to remember. But do not start steroids in the first week of treatment. Especially the first four to five days. Steroids use ch. That is the key. Okay? Generally second week. Second week. Eye painting. Symptoms. Okay. Number one. That is number one. Body oxygen requirements. My body needs. So rest is important. Number one. Okay. Number two. 90%. Definitely hospital important. There is no doubt about it. 91. 92. I think you should get ready. Okay. Hospital bed dog Cheskuni. You should get ready. 94. 95. I think you can still wait. Okay, makes sense now. Hospital Kimiru Call J Serve. Number one. Rest is code on the part. Number two. Fresh ventilation and areas are important. Fresh air. Open the windows. Open the door. Fresh air will help you a lot. Okay, Number one. Next. Number three. Proning. Okay. Pruning. The scientific term. Lungs On Tagada may be lungs. Alveola antam 8 sex on Thai gali. Oxygen carbon dioxide. Exchange Oxygen. Tiskuni carbon dioxide. Okay. Danki. All you open. I under important. Mariana. Lungs collapse. Okay. Normal paris. Heavy activities. Okay. So normally it's okay, you're fine. But Covid disease very other lung problems. You oxygen already lungs effect. Inflammation. Lungs effect of the lung damage. Because the number of lung air sacs available. Takua already. More number of lung air sacs. More lung space is available for someone to use. Okay, So proning helpful. It can buy you time. It can buy you time. Mirupriti Gantaki all right. Hospital on Napuru. Okay. High oxygen requirements. High oxygen requirements. 60%. 70% oxygen. Walaki Inca is saturation pulse oximeter low. 80% to 70%. Okay. At least three to four Times a day, one hour each. Okay. If possible, longer and more number of times. That will buy you time. That will buy you time. Okay. So. Oxygen concentrate. That will be life saving for you. That will be life saving. Of course, Japan, Whatever it is, it's cause. Oxygen concentrated. That will be life saving. It's okay, but it will be useful. Okay. So in essence that is what you need to do when you don't have a hospital bed immediately available. Okay, Last question. Vitamin D. 500 units to thousand units. All right. Vitamin D levels, Inflammation, Inflammatory markers. But in general, I'll give you a Generalized guideline here. 502,000 units of vitamin D is good. If you want to take a supplement. That is going to give you vitamin D. Okay, got it. All right. Any other. So we'll discuss more on Monday. Aditya, you're raising your hand. Do you have something to say?

Answer.

Yeah, go ahead. The last question.

Of these policies.

General Calcium. Vitamin D calcium. Old people, low actually calcium. Especially females, low osteopenia, osteoporosis, calcium. Vitamin D. Preparations available on time. But most young people, most normal people, all you need is vitamin D. You don't necessarily need calcium because you get enough calcium through food typically. Okay. It is low. Yeah. It is low, Huh, sir?

Yeah.

So vitamin D supplementation is quite important, Aditya. I think you should take it. But I don't want to say it out loud here. Because everyone will go and buy and pharmacy will be empty. Okay.

Starts in small doubts.

Yeah.

Vitamin D and A weekly. Once this.

High dose vitamin D on the low.

Dose vitamin D that is 64kV.

So vitamin D levels initial body key or Kasariga body in dumb chest. Vitamin D. 50,000 units. 60,000 units. High units. Weekly ones four to six weeks. Then we put them on low dose vitamin. So. 50,000 units. Yeah. Okay. Yamini. Okay. Is raising her hand. Last question. Okay. And then we'll have to go.

Hi, sir. 25 days, one month. Bile.

So I can review everything again and then answer you properly. Okay? Nama.

Okay.

Yeah.

All right.

First of all, thanks so much to Dr. Naidu who has provided such great information today. Valuable information in a palatable way. Thank you very much. And thanks to Srini Ja for moderating this. And thanks everyone for joining us. Okay. Okay. The purely educational program. Charitable program. Your name is Charchet. Okay. Purely education program. So come use this. All right.

Thank you Darren for hosting all this and Srinija has done a wonderful job. One last word of caution for all the audience. What sample of forward chase? If it is Too good to be true. It is not true. WhatsApp. Misinformation spread indirectly. You're saving lives. Thank you all.

That's the agenda of these call sessions also, sir. Fight misinformation and spread positivity and right information. That is the reason Dr. Kiran started this call sessions. And we all are supporting him.

We know much better than what we knew last year. Last year. Everything was speculation at the time. I. Puru. We know far more. Okay.

So.

Misinformation. That is the reason for these calls. Important thing. Actually. Subha Karanjay. He's a journalist. And he has a passion for journalism and doing a lot of good things. Hello sir. Thanks for joining us today. Thank you so much, sir.

Especially thanks to Naiduar sir.

So he lot of input, sir.

Thank you. He's not a journalist. He's a health information manager. Senior health information manager of Polar Hospitals.

Jubilee. All right. Sorry. Sorry.

Okay.

Sorry. Sorry. Yeah. Yeah. Last. So. And he's a very good friend of Nageswara also. So. Thanks so much for joining Andy. Thank you. Thank you so much, sir. Yeah. Yeah. Ah. Okay guys. Take care.

Yeah. Thank you so much. Thank you so much. Naidu sir as well. Have a nice day to you both. And thank you. Good night.

Yeah. Bye.