The Connection Between Gut Health and Hormones

13 Nov 2025 · 35 min
Episode

13 Nov 2025 · 35 min

0:00

In this episode of the Holistic Dentistry Podcast, host Dr. Sanda Moldovan, a periodontist and nutritionist, interviews functional medicine dietitian Lisa Smith. The conversation begins with Lisa’s personal story—her grandfather’s influence, a career shift, and a delayed diagnosis of Hashimoto’s thyroiditis after her second child—illustrating her motivation to help people prevent disease. They explain Hashimoto’s as an autoimmune hypothyroidism, detailing how TSH levels rise when the thyroid cannot keep up with the brain’s demand for hormone. The discussion moves to the three‑legged stool model of autoimmunity (genetics, leaky gut/intestine permeability, and an environmental trigger such as infection, stress, or toxins). Lisa describes leaky gut using a fire‑and‑garden analogy and outlines a three‑step protocol: extinguish triggers, repair the gut lining, and rebuild a healthy microbiome. Sources of triggers include glyphosate and other herbicides, pharmaceutical residues in water, chronic stress, poor sleep, and dietary sensitivities. Stress‑reduction tools are highlighted: deep‑breathing paired with habit‑stacking, grounding (barefoot on grass or dirt), nature walks, humming or singing to stimulate the vagus nerve, and the physiological basis for these practices. Nutrition advice stresses adequate protein, fiber, and plant foods while minimizing ultra‑processed items; personalization is encouraged based on individual food sensitivities. Candida overgrowth is addressed as a common oral and gut issue, with the same three‑step approach applied: remove contributing factors (antibiotics, simple carbs, alcohol), repair the ecosystem, and repopulate with probiotics. A key segment explores the bidirectional relationship between hormones and the gut. Hormonal fluctuations affect gut motility and microbiota, while dysbiosis influences estrogen metabolism via the estrobolome and the enzyme beta‑glucuronidase, leading to estrogen dominance. In men, dysbiosis can increase aromatase activity, converting testosterone to estrogen. Testing strategies are discussed, highlighting the GI‑MAP stool test (which reveals leaky gut markers, beta‑glucuronidase levels, pathogenic and beneficial bacteria) and oral DNA testing for dental health. Finally, Lisa offers three simple daily habits for listeners: eliminate ultra‑processed foods, consume prebiotic‑rich fiber sources, and identify & reduce stressors. The episode ends with contact information for Lisa’s practice and podcast. Overall, the episode weaves personal narrative, scientific explanation, and practical recommendations to illustrate how gut health, hormonal balance, and oral health are interconnected.

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