LS6 - Live Longer with David Kekich
7 Dec 2025 · 26 min
David Kekich covers the science of living longer: caloric restriction and intermittent fasting, resistance training, monitoring inflammation markers through blood work, and stem cell approaches. He discusses Inflagenet, an AI-driven supplement discovery tool he developed with Ben Goertzel, and explains why attitude and stress management matter as much as the biology.
Questions this episode answers
1999 (described as a 501(c)(3) nonprofit founded in 1999).
Smart, Strong, and Sexy at 100 (referred to in the interview as "Smart, Strong, and Sexy" / "At 100").
Ben Goertzel.
Inflagenet.
C-reactive protein (CRP), erythrocyte sedimentation rate (sedimentation rate/ESR), fibrinogen, and interleukin-6 (IL-6).
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Welcome to the Longevity Show. Informing listeners on the important aspects of health, wealth and happiness to ensure you live life to its fullest. With fascinating interviews with top authors and gurus in the field, along with the latest news in the science and technology of longevity, we're going to reveal expert advice and amazing secrets of living a longer, happier life. And now, here's your host, Jason Hartman.
It's my pleasure to welcome David Kekich to the show. He is a longevity science expert. He's president of CEO of the Maximum Life foundation and a recognized authority on longevity science. This group was founded back in 1999 as a 501c3 nonprofit corporation dedicated to reversing human aging and age related diseases. Dave, welcome. How are you?
Great, great. Thank you, Jason, thank you for having me.
Well, it's good to have you. You're coming from my hometown, Newport Beach, California, and we are living in a very exciting time. I'm sure we'd both agree on this in the field of longevity science. You know, tell us if you would, just quickly, why is it such an exciting time, Dave?
Well, I think it's an exciting time because now we're going to be able to realize the people that want to live longer. And I think everybody does, but not everybody really understands they do. It's going to become a reality sooner than most people would even ever think. And when I say extending lifespans, I'm talking about going past the maximum lifespan that we're used to seeing of 115 to 120 years. Talking about going way past that, but eventually. But what's more exciting is going way past it in a very youthful act of vibration.
Right. Health span. It's all about health span.
Yeah, exactly.
Right. Good, Good stuff. Well, why is that? You know, you talk about Ray Kurzweil, who is well known in this, and he's with Google, of course, now, and he talks about this. What does he call it? There's a name for it.
Well, he calls the law of accelerating returns. And Ray's been an advisor since the beginning. I mean, he's a great guy. He's amazing. If anybody hasn't heard of him, Google him. But I think most of us have heard of him by now. But his law of accelerating returns basically says that the information technologies are doubling in power and of course, and also dropping. The cost of it is dropping in half every year, but they're doubling in power. Every single year. So that means in 10 years they would be 1,000 times more powerful and in 20 years, a million, and then 30 billion, actually less than 30, the way he has it calculated. But this is a direct relationship now to the tools that we're using, the research tools for aging. Because biology is now very quickly becoming an information technology. We're able to. The genes, the 20 some thousand genes that we all have are little computer programs basically. And we're learning how to code those genes and decode them and program them.
Yeah, yeah, it really, really is amazing. And of course, the network effect with the Internet and such is accelerating all of this quite dramatically. You cover, you know, kind of some different ways in which we age in the book. And, and you also cover some different areas where we can improve. You know, the first and, you know, probably most obvious one is diet and exercise. Did you want to give just a quick tip or two on that? I don't want to dwell on it because it's sort of, well, it's.
Yes, you know, well, diet is what you eat, but also how much you eat and then of course, how often you eat. You know, intermittent fasting, for example. I spent some time on that caloric restriction. That's a little bit tougher most people, but I have ways around that that you can live and, you know, lose weight and live well and live longer. Less protein, a lot of these things. I update it every year, so every time something new comes out, I put it into the book.
Oh, so now, I mean, caloric restriction, I've certainly read the studies about that and the benefits. But less protein, huh? Because so many.
Less protein, but specifically less animal protein. Most of us eat way too much protein. And protein, especially with the methionine and methionine.
Is the amino acid in that. It's really high in Turkey and all animal products and especially the processed meat. This really can be your undoing if you have too much protein, the wrong kind of protein especially, but too much protein, it could accelerate the risk of cancer, it could accelerate aging and, and so forth. So I cover some reasons why in the book.
So on the protein issue, the Paleo people aren't going to like hearing that. And among the anti aging community, there's a pretty big segment of that that's into the paleo diet.
But the vegan people will love it, right?
Well, no, not really, because vegans aren't getting enough proof.
I agree.
And the paleo people, and I'm one of them, and I have a whole appendix on paleo For a whole different reason other than what you read. I have a section in there. According to an evolutionary biologist who I've known very well, one of the top researchers in aging and longevity for over 30 years has identified a way that a reason why your aging may plateau if you're on a paleo. It may not be a rhyming guy here, but your aging may plateau. In other words, the risk of you dying every year at 90 is way higher than it is every year at 50 or 60. And his hypothesis is that if you're on paleo and I tell why in the book, that.
You would basically have the same chance or roughly the same chance of dying from aging at 80 or 90 than you would at 60.
Okay, but do you believe.
Oh, by the way, one more thing. It's really a misconception that Paleo diets are very heavy in protein. Of course, we weren't back there then, but it's unlikely. Animals were fast, hard to catch, and sometimes nasty plants were easy to find. So their diet was pretty much mostly plant based.
Yeah, yeah. And I'd agree with that.
The, you know, the one point of it is though, is that the grains and the carbs are bad. They believe.
Oh, my God. Yes.
So do you agree with that?
I agree after a certain age.
Okay, what age?
At a young age. No, I disagree with it. And again, I explain all. Why. I can go into it if you'd like me to, but it's pretty long running.
That's okay. I don't want you to go into it. But I would like to know what age.
Well.
Certainly over 50.
Okay, all right.
And preferably over 40.
Yeah. Okay. Okay, good, good. And what's the next one? So we've got that out of the way. We've got, I believe, six more. Right.
Well, exercise, sometimes more will shorten your life. So moderate amount of exercise. And again, if we're talking about paleo exercise, like Paleo people lived, you do cardio, you're walking, you're running. So a combination of jogging, but not too much. And primarily interval training, and then of course, lifting, weight training, resistance training, we're just engineered to live that way.
Yeah, I would agree with you. The interval training, much better than running a marathon, which is probably not good for you. So good. What about supplementation?
Well, supplementation, there's controversy in this area among a lot of people, a lot of scientists, but most of the smart people I know are heavy supplement users, including Ray kurzweil.
He's been 150 pills a day Right, Yeah.
And I say, well, that's a little too much. But, you know, he says, no. So, but I do about 60. And they're not all different things, but it's really kind of a hit and miss game. I mean, medicine in general has mostly been discovered by accident or trial and error, and that includes supplements, supplement manufacturing and supplement development. But finally, we've been able to find an artificial intelligence technology, algorithms that are developing and finding these answers. We're doing it not intuitively anymore, but we're doing it scientifically and precisely. And we've been able to isolate the genetic networks, not just individual genes, but the networks that contribute to a number of things that contribute to aging and disease. And.
And we've then used the artificial intelligence to find networks or groups of compounds, natural compounds, that we've been able to formulate to counteract more accurately, more precisely, the effects of these genetic signals or these genetic pathways. So we came up with one, and the first one we came out with is a product called Inflagenet, one word. And.
It'S got remarkable effects on the inflammatory pathways. And of course, you know how important inflammation is.
Yep, yep. We do either die of inflammation or oxidation, they say. So absolutely. Now how do you measure that, though? How do you know that this has good effects on inflammation in reducing it? How can we measure inflammation issues?
Well, there are a couple of ways. By, of course, the way you feel. That's usually the way on an individual basis. But more objectively, blood work, C reactive protein, you might want to check sedimentation rate, fibrinogen, IL6, things like that, interleukin 6. But if you're really serious, you want to get, you should be getting blood work done regularly anyway. So you should have some of these markers or some of these baselines already set.
Absolutely. And I'm in one of the elite health programs myself, and they're doing blood work about every three, four months or so. So is that about the right interval, do you think?
Oh, I say minimum once a year. I do extensive blood work a little more often, but then I do blood work not extensively. I don't do my whole menu more than once every nine months or a year. But then I do during the year, if I see something that's a little bit out of balance, I monitor that. I change something or other to try to fix it and then go back and monitor it again.
Sure, sure. Okay. So supplementation, Dave, is different than medicine. Talk to us about the medicine component.
Well, again, medicine drugs are usually single molecules, in fact, almost exclusively Single molecules that work on single genetic pathways. And we're a lot more complex than that. And there are a lot more molecules out there than one for any one individual thing. So the drug company has a very good business model. They're very profitable, and they tend to keep people on drugs for a long, long, long time. And sometimes drugs can be real lifesavers, but other times, we lose about 109,000 people a year in this country, according to the AMA, from proper dosages and proper prescriptions of drugs. So we. I think this. Well, I know the AI will be working on drug discovery within a couple few years. We're developing an AI scientist now, and that will take about two years, actually. We're just putting the company together to get the first big milestones and get the first working model that'll be essentially the smartest researcher and the most efficient researcher in the world. You can apply this to any number of things. We're focusing on longevity with this thing right now, but once it's up and running, it can be. It can branch off to different areas.
Yeah. So in terms of the artificial intelligence, is that a specific university or a specific machine, or. Are you just talking about artificial intelligence as a conceptual technology that is being used worldwide?
We're using who is purported and is very, actually very widely recognized as the top AI biology specialist in the world.
Who's that?
And he's got a company and he's got a network of researchers under him that expands the globe. It's not a huge network, but he's got people in many, many, so many things are virtual now. You don't need a lab because you need a computer.
Right? Yeah, yeah, absolutely. And who is that, by the way?
Oh, that's Ben Goertzel.
Okay. Okay, good, good. Okay. So, yeah, in the field of medicine, you pointed out some good things there. What's the next one?
Well.
Actually, the different technologies. We enter the field of medicine, of course, we're all familiar with stem cell medicine and regenerative medicine. I'm not sure how many of us are familiar with the SENS strategy that. The Aubrey degrey strategy, SENS Research Foundation. But it's basically to repair the damage that aging and other nasties of life inflict on us.
Right, right. We had Aubrey on the show.
It was very interesting. Oh, great. Okay, then I don't need to go into that.
No, no, no, but you can go into it a little bit. I mean, that would be great because that was a while back.
Well, do a little self promoting now. Aubrey actually got his idea. At least the germ of his idea at a conference that we held back in 2000, and he was pretty much unknown at that time, and it was in Manhattan Beach, California, and we ended up calling it the Manhattan Beach Project.
I love that name, by the way. That's so fantastic. And, you know, obviously comparing it to the Manhattan Project of World War II, but yeah, okay.
And of course, ours is to solve aging rather than to build the bomb. And Aubrey, while we were all out having fun and talking that night and sleeping, Aubrey sat up all night, and he.
Based on.
What triggered his fertile brain on the Friday or Saturday, the first day of the session, he stayed up all night and ended up coming down and having. He had his sens. Strategy formulated. At least it was roughed. I shouldn't say it was formulated. And it's been all up from there. And we're really happy and proud of Aubrey for doing that. But essentially he has a strategy to keep us alive, I don't think indefinitely, but certainly to be able to keep rejuvenating us from time to time, or at least specific organs and in time to catch up to the other technologies that we're concentrating on. It's a big part of our plan. It's a big part of our scientific roadmap to reverse aging.
Yeah. Yeah, fantastic. What about lifestyle? I mean, you know, obviously, in terms of lifestyle, health plays into it, but, you know, there are some simple things like just avoiding accidents and things like that. Right?
There are. And to lower hazard risks, I list a whole bunch of things in my book on how to do that. Did I give you the name of the book?
Yeah. No. And you know what? I did not even announce it in the intro, so please tell us.
Okay, I'm sorry. It's smart, strong, and sexy. At 100.
At 100. That's awesome. Fantastic. And so, you know, any tips on the lifestyle part?
Well, it'd be pretty stupid if you.
Stepped in front of a bus. And if you're doing everything right, you have the right diet even. You're investing in the technologies, and you're doing all the things. You're a cryonicist. And so it's just.
Most of it's common sense, but most of it are things that people of us. Most of us just.
And one of them. And I don't want to sound like a conspiracy theorist or a pessimist, but one of them is to really be prepared for emergencies. And the longer we live, the more likely we are to be affected by some sort of social upheaval. And that could be anything from our grid going down. Of course it could be terrorism, which is a big thing now. Could be course storms and all sorts of things here in California, tidal waves. Maybe that's why you moved to Arizona. But I do go and spend some time on that and how to be prepared and how to survive some of these things that could likely disrupt the lives of those around you and possibly even kill a lot of them.
Yeah, and I think that's a very good point. I have a whole show, it's actually my second most popular show dedicated to that. It's called the holistic survival show. So preparedness, it's just smart folks.
You don't have to be some nutty guy who lives in the woods with a shotgun to be prepared. It's just smart to be prepared because things will happen. And we've seen that all over the world and we've seen it in the United States. You know, whether it be, you know, Hurricane Sandy, Katrina, you know, I mean, it's just, you know, this is just, it's easy, it's inexpensive, it's just smart and prudent. So.
Yeah, and you know, we get, we get hung up on day to day stuff and, and just put those things off.
Yeah, you can, you can literally do some of the, just the basics for $100 per person in your household. I mean, it's just nothing. So, you know, if you don't do this, you're an idiot. So be prepared. Okay, good point, good point. Move on to the next one if you would.
Well, anti aging medicine, I think most of us know there are specialists out there who are anti aging docs and just use them. I mean, find a good one. The whole key is finding a good one. Whether it's an anti aging doc or somebody else. Just because they have these credentials and some of them are not hard to get, it doesn't mean they're good doctors. So.
Just do your homework, do your due diligence. I mean, do way more due diligence on your doctor than you would on your mechanic for your car. But you know, the biggest, the most, I think the most important chapter in that section of these seven steps is attitude. And it's something again that most people overlook. And it's the attitude that you need to put the diet and your exercise programs to work for you the most efficient way. How to approach stress, how to approach the whole ball of wax. And attitude can really contribute to your lifespan. How you think affects every single cell in your body, trillions of them. And that's been proven. I show why in the book. How with the studies.
It'S all your thoughts, negative or positive or working against you or for you.
Yeah, great points, great points. Attitude certainly is critical. It's part of psychosomatic medicine. And the body does manifest what the mind harbors. I've met so many people throughout my life, Dave, who just. They're just old before their time, you know, they just. They've kind of given up. It's a terrible thing to see.
It's sad. I saw that in my family and I saw it with some of my friends, and they don't last long after that.
Yeah, yeah.
Did you know that the placebo effect has been tested on knee surgery?
You know, I heard about that recently, but I can't imagine that they actually performed fake surgeries on people.
How did they get away with that? I would think that would be massive medical malpractice.
Well, it was a controlled study, and apparently it was something that the IRB or the NIH or somebody thought was maybe. I'm not sure who was behind it or who funded the study, but apparently that was important enough to find out the test. But they found the people who had the dummy surgeries did just as well. They had just as little pain, they had just as much increased mobility as the people with the surgery.
That really is amazing. I mean, the power of the placebo effect has been tested and verified many, many times. But that comes with non mechanical things. You know, it comes with sort of, you know, things that aren't just hard mechanics, like knees. And so that really is an amazing study. I mean, I just. I don't know how they pulled it off, you know, as I mentioned. But it is amazing. No question about it. You know, one thing especially men are concerned about. And you talk about it in the book. Well, and you know, women are concerned about this stuff too. But, you know, hair.
You say, you know, new skin, new hair, new you. You know. Do you want to mention anything before you go specifically related to those areas, Dave?
We're working on a specific technology with another company that is a stem cell company. And this technology would be able to amplify. It would be able to amplify cells, stem cells, for example, an endless number of time without them degrading. And of course, the telomeres shorten every time the cells divide. So this technology would keep that from happening. In fact, maybe even make the telomeres lengthen. So let's say if we took skin cells or hair follicle stem cells and amplified Those and made them younger and then re injected them or I should say micro inject them into the skin or whatever. We could potentially set back the skin aging by decades. And it would be a permanent fix in the respect that it would be. It would take those decades to get back to where it was before. And of course this technology is being developed for rejuvenation for organs. Of course your skin's your best biggest organs. But I gave a presentation one time at a health and longevity conference, had about 1200 people in the audience and I was talking about some of these stem cell technologies and people were going, oh yeah, their heads are. I was getting positive feedback. And then I said imagine the hearts and imagine the livers and kidneys.
Being regenerated. Yeah, yeah, that's great. And then I said imagine having the hair and skin a 25 year old. And that place just basically exploded.
I mean here are people who came there for health, but the big hot button was appearance. And it just told us that, you know, the way to fund this technology is to first have an application for hair and skin and also for the, the regulations are much less stringent.
Right, right.
So that's where the, that's where this company is going to have its initial efforts.
Yeah, yeah. Well, you know, you kind of, you kind of chuckled at that a little bit and I, it's interesting because, you know, part of the whole hair and skin equation is really the placebo effect. You know, it goes into how one feels, feels about their chronological age versus their perceived age. And I think that is not a shallow thing. You know, I think that is a legitimate part of anti aging science is that, you know, when you look in the mirror, the person you see reflected back to you, it shapes your perception. And as Earl Nightingale taught us so many years ago, you know, the environment is a mirror of ourselves and in this case the environment is our bodies and our mind and the. So we're shaped by the environment, but we also shape the environment so it becomes this circular equation. And that's important. I don't think it can be minimized.
Which explains why I'm keeping Just for Men in business.
Yep. Oh you are, huh?
So Just for Men. Now what is Just for Men is that the, that's the hair dye.
You'll learn, you'll.
Oh yeah, yeah, yeah, yeah. No, right. Just for Men as the hair dye. It's like the comb in gray stuff. Right, right. Is that. Yeah. Ok.
So are you an investor in that company or something?
No, I'm not. I am a consumer oh, you mean.
Okay, I understand, I understand. Good, good stuff. Well, tell people where they can get the book. You know, it's on Amazon with, with five star reviews. And again, let me give out the title for you too. It's smart, strong and sexy at 105 star reviews on Amazon. And you know, can they get it anywhere else or is it strictly Amazon?
They have to go to your store and order it. Easiest thing is am. And if you get it and if you like it, don't be bashful about giving me another five star review.
Yeah. Thank you.
Tell us what your website is though, so they can find out more information about all the research and so forth.
There are two. One is maxlife.org and the other one is maxlifesolution.com Fantastic.
Maxlife.org and maxlifesolution.com Dave, thank you so much for joining us today. Really appreciate it and keep up the good work.
Great. Thanks a lot, Jason.
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