Jeffrey Jaime explains how NAD and Sirtuin 1 control your sleep-wake cycle. A large IV dose of NAD can disrupt your circadian rhythm for days, and taking it at the wrong time kills the benefits of Sirtuin 1 supplements. Take NAD in the mid-afternoon instead.
Mid-afternoon.
It will "screw up" circadian rhythms for several days.
I actually use a lot of NAD too. Oh, oh. So let me stop you there. Okay. I went on this huge circadian rhythm binge and what I discovered was absolutely astounding because everyone, every time you go to a lecture on sleep, it's, you know, avoid external stresses, lights, food, exercise, et cetera before you go to sleep. But as it turns out, there are two proteins that put you to sleep. There are two proteins that wake you up and there are two proteins that increase the oscillation of those cycles. And NAD and Sirtuin 1 are they sort of rule over all of your circadian rhythms, all of these. So if you do a giant IV bolus dose, you are going to screw up your circadian rhythms for several days. The other interesting thing about it is if you take your NAD supplement at the wrong time, you can decrease the efficacy of your Sirtuin 1 supplement. So the best time to take it is actually mid afternoon.
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