Revolutionary Hormone Hacks: Is Bioidentical Hormone Therapy A Cancer Risk?

So I like to use estradiol for most things because estradiol is our most important hormone for women. It's your. It's the equivalent to your testosterone. So estradiol is the one that is shown in research to be brain protective, like incredibly brain protective. Your risk of Alzheimer's and dementia drastically reduces from estradiol hormone replacement therapy, like between 77 to 79%.

Oh, wow.

Isn't that insane?

This episode is brought to you by, really, the best way to nuke zombie cells. When you look at this buildup of senescent zombie cells in your body, it turns out that although these things churn out inflammation, like, well, zombies, there's ways you can fight against them. The good folks at Neurohacker Collective are experts, and they've cracked the code at nuking these zombie cells in a safe and effective way with just two days a month of using their Qualia senolytic. You get a pack, take six capsules one day, six capsules the next day, set it, and forget it for the next month. So if you want 15% off the best way to nuke zombie cells, go to neuro hacker.com bgl15 and use code bgl15 for 15 off any purchase. That's n e u r o dasher.com forward slash bgl15 and use code bGL15 for 15 off of any purchase. Enjoy nuking your zombie cells. Kiss them goodbye. All right, so you know when you're talking to a true expert, when they just blow your mind with all sorts of cool information, in this case about hormones. And I was at Dr. John Laurenta's clinic a few months ago at an event there. And we all went out to dinner afterwards, a bunch of the speakers to this great place. What was it called, Karen? It was Layla's.

Layla's or Lila's. Lilas. Leila's. Yeah, something like that.

Something like that. Anyways, one of the cool, healthy places that we could hunt down in Sarasota. Yes, good place if anybody gets connected, gives a chance to go there. But anyways, Karen is an expert in hormones, specifically bioidentical hormone therapy and a holistic approach to addressing hormone dysfunction and endocrine issues in women during peri and post menopause. I realize that's a mouthful, but basically she filled me in on a ton of stuff during dinner, and I thought, gosh, I gotta get Karen on the show at some point to talk about all things women's hormones. So as we go down the road of this discussion, please know I'll Include juicy show notes if you go to BenGreenfieldLife.com Martell which is Karen's last name. M A R T E L. I'll link to her website, her programs if you want to work with her. All the information will be there in the show notes@bengreenfieldlife.com Martell. Karen, welcome to the show.

Thank you for having me. And you left out the part where of course, like all, all the labs come out at dinner, showing me on your phone and you were supposed to follow up and send me some new labs which you have not done yet, so.

That's right. I know I'm slacking. I'm slacking anyways though. So, you know, I'm just curious about how you came into this journey and how, how you personally have managed your own hormones as you go through aging.

Yeah, well, my, it was like my whole life kind of led me to this point, like how it usually does with practice health practitioners. And when I was in my young 30s and I had my daughter, after I had her, I had a whole slew of hormone problems. And nobody of course told me at that point, I'm 31 years old, like that. It was my hormones and I was rapidly gaining weight without changing anything. I was having digestive problems, I couldn't sleep, I had chronic insomnia. I, it was terrible. And so what did I do? I went out and worked out super hard, harder than I'd ever worked out before in my life, was doing CrossFit, was starving myself, trying every diet under the sun because that's what everybody was telling me to do. And I only continued to get fatter and fatter and fatter until I was like, something else is going on here. And I decided that I had to figure it out for myself. And I decided I, I think it has to do with my hormones. And so I had my hormones properly checked and sure enough, I had all this hormone dysregulation, fixed it all up, was good to go, lost the weight, felt awesome. And then became a weight loss coach for women and a nutritionist and decided, you know what, there's got to be more women like me who are doing everything right, healthy eaters, exercising, doing all the things and so still can't lose weight or have weight loss resistance. And so I kind of went into that field of work for a long time and thinking like I had it all figured out. I'd been following a paleo based diet now for over 10 years. I was like exercising all the time. I was, I felt great Looked great and was like, oh yeah, menopause, oh, it's going to be so easy on me. Like I've got it all figured out. And then I hit 42 and I hit early menopause and I started losing my cycle. I was having hot flashes and night sweats. I started gaining weight again without of course changing anything. And I was like, you've got to be kidding me. This is happening again. And at that time I hadn't really dived super deep into hormones and I had it in my head like everybody else did that, you know, menopause was going to be this kind of short stint. I was super healthy, it was going to be easy to get through. And then, you know, I would explore maybe hormones down the road. And so I had to figure this out once again all on my own and then decided women are not getting this information. Like it was hard enough for me to find out, even though I was in the industry to find out good quality information. And I just went on this crazy deep dive and it hasn't stopped. And so now I've, I, you know, I started my own telemedicine company and we're helping women all through North America and around the world to get their hormones, hormones straightened out and getting the information out to them.

So what was your, your formal education at that point in medicine?

I was just a certified nutrition coach.

But now you have a doctorate, is that right?

Nope, I am just a, I. Another certification and then I've now trained in the menopause method with another world renowned gynecologist I trained with, did her course and so I've done a whole bunch of different courses. And so it's kind of this. I've, I've gone out and taught myself from as many, from as many people as possible, which is to my advantage, I feel like, because I'm not stuck in one protocol, which you'll, we can talk about this later. But that's what a lot of women run into is finding people that are like, it's this way or the, or no way. And we really need to look at it from a holistic point of view and from an individual's point of view.

Yeah. How's that work as far as like regulations go? Like what you're allowed and not allowed to say if you're not an actual physician?

Well, lucky for me, I have, I work with doctors and that do all the prescribing as well as a nurse practitioner who sees all the, all the clients. I do do hormone coaching and so I can do all the holistic hormone coaching. I can make recommendations based on people's labs. I've been trained in lab lab reading and interpretation. So I can do all those things. I just can't prescribe. I can't be like, you have to go and take this or anything like that.

Yes. You have doctors on your team who can do that, though?

Yeah.

Did. Do doctors learn much of this stuff in medical school?

No. So I have read that in between 0 to 7% of doctors, medical doctors will learn about menopause, and they do not learn about perimenopause, and they do not learn about bioidentical hormone replacement therapy.

Wow. Yes.

So sad.

So when it comes to. To bioidentical hormone replacement therapy, we'll use the abbreviation BHRT to save us several minutes on this show. How do you actually describe that to people?

Well, it's best to kind of go back in history and kind of figure out where, you know, hormones kind of came from and where they came when they came out onto the scene, which that was back in the 1950s, and it was hormone replacement therapy, and it was Premarin, which came from pregnant horses urine. And so that's. Yeah, it was like the. It was. It was great. It was. Even though it wasn't bioidentical to our. Our estrogen, you can imagine our estrogen does not look like a pregnant horse's estrogen, but it worked really, really well and still acted on our estrogen receptors and gave us amazing relief. Such great relief. But that by the time it was 1992, Premarin was the number one most prescribed medication in America, which is crazy. So number one, like, by 1997, sales exceeded $1 billion, and that was for premrent. And so a big study came out. I'm sure you've talked about it probably on your podcast, but the Women's Health Initiative started.

I haven't really talked about it, so. So you can fill people in.

Yeah. So this is where most women have a real fear of bioidentical hormones or hormone replacement therapy. And whether they know it or not, this is where the fear comes from. Is the WHI study set out to prove that premren and medroxyprogesterone, which was a synthetic progestin, could help lower your risk of cardiovascular disease. They had 160,000 women in the study. There's two arms of the study that were on hormones. One arm of the study, the women had no uterus, so they put them on Premarin only because without the uterus, they didn't need to protect the uterine lining. The other arm of the study, the women were on a combination of premarin and medroxyprogesterone acetate, which is a synthetic progestin that did protect the uterine lining from overgrowth from the estrogen. Estrogen and progesterone work very like yin and yang to each other. So study went on in about a couple of years. About five years into it, the WHI halted the study early, came out to the world with a report in JAMA saying that they had to stop the study because there was. They saw an increase in. In breast cancer, stroke and cardiac events. And this word went out to the world and our in women on hormone replacement therapy dropped by about 70% literally overnight. Like it was like every doctor pulled their patients off of it was like, estrogen causes breast cancer. And that's all anybody heard. And it's all anybody hear still to this day. Well, the exact same people, the WHI people that ran the study have now come out to say, whoops, basically because they've reanalyzed it and they realized.

And when did they reanalyze it?

They've reanalyzed it several times. Not just whi, but many different institutions have reanalyzed this study. But they did. They actually right away came out to say, oh, it was the arm of the study where the women were on the medroxyprogesterone and the premon and the arm of the study where the women were on premin only had a 24% reduction in getting breast cancer. Not only that, the women that did go on to get breast cancer by some unlucky chance, they had a 45% reduction in dying from the breast cancer. So it shows that the premarin was breast protective, horses estrogen was breast protective. And we have, they have come out that you can find this in PubMed. Do we hear about this? No. And women are still being told to this day by their doctors that they can't use estrogen because it's going to cause breast cancer. And if they have to use it, not they can't use it until they're in menopause. And. And only for a small amount of time in the littlest amount possible period. And so it's become this like death wish for women if they want to go on hrt and they're so frightened of it. And this is very prevalent. I hear it every day in my practice. I had a woman just last week who's been bleeding for three years and she's going to her physician, the gynecologist, a nurse practitioner. She's 50 years old, and every single one of them, 20, told her she cannot start HRT until she's in menopause. And she can. She can only do the birth control pill. And guess what they put in her arm? The implant. Medroxyprogesterone acetate pill. That's what is in birth control pills, ladies, is the same synthetic progestin. It's the same thing. And yet we're handing this out like candy to our teenage daughter. Oh, you're 13 and you've got acne. Here's your birth control pills. Here's women that are in menopause, not even sexually, like, can't even get pregnant, and they're being put on birth control pills instead of hormone replacement therapy, which is raising their risk of heart attack, stroke, breast cancer. It shrinks parts of your brain, it ruins your gut microbiome, destroys your natural hormones. And yet this is all okay. And so women are not being told the right information. And we know now, like, that, that study itself, and those results are now, right now, being replicated in a huge study called the 7 Million Study, where there's 1.5 million women that they're studying on HRT and it's showing the same thing, that women that take premarin only or estrogen only are having a reduced rate of breast cancer.

Now, I'm assuming that synthetic progesterone and Premarin from the. From horse urine is different than B. HRT than bioidentical hormone replacement therapy, right?

Yeah. So now we have the option of bioidentical hormone replacement. You can still get Premarin, and it's still the one that's been shown in the studies to have great breast protection. But now we have bioidentical hormones, which comes from Mother Earth, Mother Earth, soy and yam plants, which they can extract a chemical from there and make a hormone that is identical to your own, so your body knows no different. And so you can use it transdermally, which is much safer. And there's no increased risk of heart attack and stroke when you use estrogen on your skin or in a suppository form or injection, as long as you're not swallowing it. We don't want to ever swallow estrogen, and it looks exactly like our own. So this hormone. So you can imagine, unfortunately, there hasn't been any study done on it or very little study done on bioidentical hormone replacement therapy. Estrogen and breast Cancer, but it's, it'll hopefully be coming.

How do you know? Like if you're a woman and you're listening right now, how do you know if you would be a candidate for something like that?

Very, very few women aren't candidates for it. And you have to, you have to always remember that these are hormones that you'll, you, you produce in mass amounts from the time you're 13 to the time you're usually in your late 40s. And so through all these decades, these hormones are being produced every month in huge, large amounts going up and down. And so if you've had these hormones your whole life and they've been safe for you and they've protected you, and they do way more than just help us to become pregnant and give us a period, then most women are safe to continue to use bioidentical hormones as, as long as they really want. Now there is a small subset of women that have certain breast cancers that, so estrogen is a growth hormone. It does not cause cancer. However, if you have breast cancer cells in your breast and they're estrogen positive, estrogen can make that proliferate. So that's where that like, well, but doesn't estrogen like cause breast cancer? That's where that's coming from is that it can make that grow. So if you've had a history of breast cancer, there's still options. We know that testosterone therapy won't convert to estrogen in the breast tissue, is very breast protective. Um, women can still use it in the, as a vagina suppository to have better vagina health. So there are options for women post breast cancer that you know, if they did still want, you know, if they want that relief, they could use it. And they are actually showing now like there's a great guy, Dr. Avren Blooming, who's a world renowned on call breast cancer oncologist who is giving women estrogen replacement therapy post breast cancer and, and having great success. And it's showing less reoccurrence when women use estrogen therapy. So it's, you know, once again we need more research and it's really up to the woman if she, you know, some women really, really suffer, Ben. Like I mean really suffer. So a lot of them say I, I want quality of life. And so without their estrogen they feel so terrible that they're willing to still go and be on it. And they have to work with their oncologist and work with a trained hormone specialist and together come up with a plan that's going to work for them.

Yeah, that's an important subtle nuance regarding the cancer. You see that a lot in nutrition and supplementation and medication research like the China Study by T. Colin Campbell that suggested that a high protein diet could cause cancer, when in fact a large amount of protein and extensive stimulation of MTOR in rodent models with pre existing tumors that they initiated in studies then fed a high protein diet to, that was an issue. Right. But it's not like. And, and people took that and then said, well, a high protein diet causes cancer. No, it doesn't. But if you have a preexisting tumor, you should be aware of not stimulating MTOR and not eating a high protein diet and maybe taking more of like a, a ketogenic low carb moderated protein approach or you know, a few years ago there was, there was another one with nad, right. And I think this was NAD related to breast cancer. And it suggested that there might be, I believe, some type of angiogenesis or growth of tumors in response to high dose NAD in people who had breast cancer. And again, the headline said NAD causes breast cancer. And so, you know, there's these subtle nuances between the type of approach you take if you have cancer versus the type of approach you take if you don't. You know, does that make sense?

It does make sense and I think you're spot on. I mean, it's, there's so many nuances to these and cancer is complicated. There's a lot that goes into it. And I'm not claiming to be a cancer expert. I just know from the, what the research has told me, you know, and so if you've got breast cancer. Yeah, you really do want to work with somebody that knows what they're doing.

What kind of things do you look for in labs or symptom based when a woman is, let's say in, you know, close to that early 40s time range that you alluded to to know if they actually are going to need something like this.

Right. So most women start to lose their progesterone in their late 30s, early 40s. And that's when we start to see symptoms of perimenopause starting. So perimenopause can last anywhere from 10 to 15 years, which most women don't know that either. And that's like the worst part of it is the perimenopausal phase. And a lot of women don't even, they don't even know to, to say that it's their hormones because it starts to Creep up quite slowly. But the less you ovulate, the less progesterone you're going to produce. And at that point in time. So let's say you're in your late 30s, early 40s, and you're not ovulating very much anymore. Like I wasn't and my progesterone took a total nose dive. You, there's nothing you can do to bring that back. Like there's, you know, stuff you could probably do still in your 30s, you could take things like Vitex and there's different supplements that can help nourish the ovaries and kind of squeeze out the last bit of those hormones. But once those hormones are gone, they're gone. And there's no amount of supplementation, diet, adrenal health, stress health that you're. That's going to bring these levels back. It just doesn't work like that. And so we're being told by social media out there that, hey, just eat a high protein diet, diet intermittent fast, do your cold plunge, do this, do that, and, and you'll be able to get through menopause. Watch your stress levels because your adrenal system will make your hormones once your ovaries don't. Well, your adrenals make these like little tiny baby amounts and that most women don't feel good about on. Right? They don't. You, when you test them, they don't look like they have any. So the adrenal system doesn't. Isn't this like great backup source of sex hormones? Once those hormones are gone, they are gone. And so if you are getting symptoms, there are some things that you can do to maybe damp her down, tamper down those symptoms. But in most cases, 80% of women will have symptoms of perimenopause. And the best way to eradicate those symptoms is to start replacing the hormones and not wait until you're in menopause, which a lot of doctors will say, oh, just wait till you're in menopause and then we'll maybe give you some. That's not the way to do it. Do you want to go 10 years with suffering having your vagina drive up, dry up your, no more muscle tissue, you know, your brain's gone, you got to quit your job. Do you know how many women quit their jobs because their brain is so foggy because of the hormonal loss? And so it's really about, yes, we want to see labs and we want to see like, okay, what's happening here? You know, we want to get a Baseline. It's always good to actually have the baseline done when you're still feeling good and you still have a regular cycle. So you can go, okay, this is the window that I feel good in because every woman is different. I'm genetically, I'm really estrogenic. So when I start dropping an estrogen, I get all of the symptoms. I get the weight gain, I get the night sweats, the hot flashes. When my sister, she's super androgenic, she's little, tiny, skinny, wiry woman and you know, she loses her estrogen, she barely feels it, but she loses her testosterone and she falls apart. And so genetically, some of us are more prone to being one or the other. And then we're going to be more sensitive when those hormones start to drop. So had somebody looked at my levels, they would have been like, oh, she's in range. I mean, the range is ridiculous. Like a woman's estradiol range is like, oh, if you're between, you know, 20 and 500, you're totally fine. You know, so it's, it's really about, okay, what we're, if you're not feeling well and you're getting symptoms, then that number is not a good number for you and you're not optimized. So we really need to listen to women and go, okay, how are you feeling? What's happening? And then be able to go, okay, it sounds like your testosterone's not high enough or your estrogen's not high enough.

So, so for testing for something like this, you know, the way that I've seen things positioned in the past has been blood test kind of gives you a snapshot. A salivary test gives you a 24 hour index, and then a urinary test gives you a 24 hour index plus upstream and downstream metabolites of hormones. You can see how they're being metabolized. Do you use a specific testing protocol? Like the urine one I know is called the, the Dutch, for example. I know I've heard good things about that one and I've seen good results from it. But I'm curious what you do.

We prefer to do both blood and at the same, on the same day, do a urine metabol test. But the urine metabolite test is expensive and so a lot of people, they can't afford it. And in which case we'll just ask that they do their blood work on a very specific day of their cycle, which is day 21 of a 28 day cycle, or seven days before your period starts, so that we can see because your estrogen, progesterone, testosterone, it fluctuates throughout the month. So we need to have it on a day where there's actually supposed to be a rise in both estrogen and progesterone so that we have something to compare that to. So because if you were to test progesterone in the first half of the cycle, it wouldn't show anything. So we want day 21. And yes, serum is going to test what's called bound hormone levels, and that's bound to sex hormone binding globulin. You can think of that as this little bus that shuttles your hormones all over the system. But it has to get off that bus in order for the cell to be able to, to, for it to dock onto the cell. And so that can, that can be really misleading because some people, for instance, that are on thyroid medication, like myself, it raises sex hormone binding globulins. People that have been on birth control pills, it raises sex hormone binding globulin, oral testosterone raises sex hormoning glavion. So there's all these things that can raise this. And so you're, you could look like you have great levels, but it's not testing free levels of hormones.

The, the serum test is only showing the bound version. So your levels could show fine. Now on the serum test though, wouldn't it also show if you were to test this, if sex hormone binding globulin was elevated?

Yeah, so I, yes, we like people to test for that too. We always have it on our lab, request requisition and then urine's gonna give. It's only testing metabolites, but it gives you a reflection of free levels of hormones. And then plus it's just so people.

Know when you say metabolize, what do you mean by that?

So break it down. So when we need to be able to break down our hormones and get rid of them. And there's three phases of elimination. So there's phase one, phase two, phase three, phase one. You know, the estrogen has to go down these three different pathways, and we want to see which pathway it goes down because one of them can cause more DNA damage than the other two. So and then from there, and that's called hydroxylation, and then it goes into methylation. So we want to see kind of where a woman's being held up possibly with her metabolizing of hormones and then also gives us the androgens. As well. So some women are really prone to converting testosterone into dihydrotestosterone which is a very masculine form of testosterone. And that will give a woman more masculine features. So she. So we could see that on a, on a Dutch test will be like, okay, you are somebody that really pushes down what's called the five of a reductive pathway, which means if she goes on testosterone replacement therapy, she may run.

Into going to get a handlebar mustache.

She may get a handlebar, she may grow a clutinas, as I like to say. So you got to be very careful.

A clutinas, I can hazard a guess as to what that means. But is that like an enlarged clitoris?

Yes. Like, okay, it does start to grow for some women. Okay, we've had that happen.

Yeah, got it. So. So when you're testing all these things, I imagine at some point you're sitting down and designing a repletion protocol using DHT. But I'm just curious, like, what's it look like as far as delivery methods? And you mentioned transdermal estrogen earlier, but I'm just curious what the package looks like for a woman.

Yeah, so when we, when we work with women, we are looking at that whole picture because hormones just still don't, they're, they're great, but they're not gonna fix a bad diet or a fix of that, you know, exercise program or anything like that. And we want to be healthy. We want a healthy gut system. We want to be exercising. We want to be, you know, maintaining our muscle tissue. All the good things, all the lifestyle factors still have to be in there. We want to make sure that that's the foundation because then your body's going to take on these hormones a lot better. And then we'll usually start, like, depending on the woman, of course, let's say she's in menopause or she's far into perimenopause and she's got no progesterone, estrogen, testosterone. So typically we'll do an oral progesterone. You can have oral or transdermal. Both of them work great. Oral works really good because it has a lot more anti anxiety effects to it. So a lot of women really like that. And then the estrogen, we always typically start with a cream or a patch. Those are the two top things. With that and then with testosterone, we prefer injectables because cream can cause hair growth, more hair growth than injection. And like, I just heard from a woman today, she said, I've been using cream on my inner thighs and I'm growing lots of dark hair there now. And so she's like I want to switch to injection because it has less of that conversion to the, to the dihydrotestosterone. And we just see it coming up better over and over again. We see this where transdermal testosterone for women and just doesn't absorb the same and it doesn't get the levels up well enough so that you always end up having to use a higher dose which then gets more costly. Rather the injectables, it's a once a week injection. You know, you could do sub Q or IM and it tends to, you don't need to use nearly as much. Like we're talking 10 milligrams a week compared to 5 milligrams a day if you were to use cream. So it's a big difference. So it's more cost effective. It's easy because you just inject once a week. And so women really like that. We don't do pellets at our clinic. I'm not really one for pellets. I know some women really like them but we prefer not to use them because once pellets are in. So if your audience doesn't know what that is, they put these little, they look like little rice things. They put the, they implant them in your butt and then you can't get them over three months. And so it's.

You mean, you mean like in the skin on the buttocks? Yes, yeah, underneath the skin. Okay.

Yeah. And it gives you, it's supposed to give you the slow release of testosterone over a three month period. But typically we see really, really high levels up to the hundreds for women, like masculine male levels, which would be.

An issue because then you're going to get conversion of that into dht, right? Potentially.

Potentially. If you're a high converter, yes. And so some women are like, oh, it's amazing. It's so easy and great. And then we've had other women that have been like, I gained 20 pounds, I got acne all over my face, started losing my head hair, started, you know, having clitoral enlargement, labia enlargement, chin hairs, voice cracking. And they can't get them out. They have to wait that out. So I always say if you want to do pellets, first find out how your body's going to respond to testosterone either through injection or through cream. Once you know that, then you can explore if that's what you choose to do. The pellets.

Right. Because once the pellets in there, it's in there. Unless you want to do your own Little home based surgery with, with some tweezers and a kitchen knife, right?

Yeah, yeah, exactly, yeah, yeah.

Don't recommend that.

No.

So the, the oral versus the transdermal progesterone.

Yes.

Why is it that I hear a lot of people recommend, you know, take a little progesterone, put it on the inside of the arm or the inside of the thigh. But it seems like you recommend oral.

No, I, I prefer cream, actually.

Oh, you do?

I do, yeah. Yeah. I have my own line of progesterone cream. I love.

The, the or. So when you swallow progesterone, a, it's not the natural way your body makes it and processes it. It shouldn't, it doesn't go through your first hepatic pass of the liver, it doesn't go through your digestive system when you're taking it oral. It does. And so what happens is a, you got to use a much higher dose. So typically anywhere between 100 to 200 milligrams and 80 to 85, about 80% of it is going to convert to the progesterone metabolites. So it's obviously you get two different drugs out of this. So the metabolites can be, is what is really calming. There's one specific metabolite that acts on the GABA receptors of your brain which induces calm and helps women to sleep. And you get this big dose of that and then, then you're going to get about 20% of actual progesterone or rather the cream. It's more natural to put it on the skin as a way to process it. It's not going to convert to the metabolites to that extent that the oral does. So you don't get as many. You still get some, but not as much. And so progesterone cream, you don't need to use as much. You use about half. So usually around 50mg is a good dose. 50 to 75 for women in menopause is great.

Yeah. I don't know if I mentioned this to you, but my wife uses a transdermal progesterone and I'd heard that about anxiety and the anxiolytic effects of it. I've tried it a few times on nights where I've been super hyped up to assist with sleep and it actually does have what seems like a pretty potent anxiolytic effect. Do you have guys who are stealing their wives progesterone or have you heard that before?

Oh, yes. Yeah, for sure. You guys produce progesterone too. You typically aren't deficient in it, but it'll work the same way. I'll do that if I can't sleep. Sleep. I wake up in the middle of the night. I have my progesterone on my nightstand. I just take a pump and I just rub it on my chest and it'll take me back to sleep again.

Yeah. Have you seen. Have you seen that book? There's a guy who even prescribes it for, like, kids with ADD or ADHD.

Yeah.

For people with anxiety. Yeah. Dr. Platt, what do you think about that?

So I've interviewed him. I actually did some of his program for him, talked with him for a long time.

So he uses extremely high doses, and he does them. He. He recommends doing it every day, which I disagree with, because you can start to suppress estrogen if you do that. And he's. He'll be like, oh, take. You know, to got, to men, to kids, to everybody. It's like, go ahead and take 200 milligrams of cream a day.

Yeah. It's a secret sauce. Yeah. His book makes it sound like it's just the miracle cure.

Yeah. And. And you don't want that much progesterone. You can start to run into some problems. And actually it shows in some of the research that it can actually lead to insulin resistan.

He's.

He's saying it's going to cure the insulin resistance or at least help it. And so we can see the opposite effect of that. And then he. He thinks that he's a doctor that thinks that estrogen's the devil and he's going to cause breast cancer. So I had to kind of go, oh, you're such a nice old man. I love you, but you're wrong.

Yeah. Now, the estrogen piece, you. You talked about progesterone and testosterone delivery methods, but I've seen two different forms of estrogen described before estradiol and one called biest, if I'm pronouncing that correctly. B, I, E, S, T. What's the difference between the forms of estrogen repletion and what do you like to use?

Okay, so I like to use estradiol for most things because estradiol is our most important hormone for women. It's your. This is. It's the equivalent to your testosterone. So estradiol is the one that is shown in research to be brain protective, like incredibly brain protective. I mean, your, Your. Your.

Risk of Alzheimer's and dementia drastically reduces from estradiol hormone replacement therapy, like, between 77 to 79%.

Oh, wow.

Isn't that insane? There was a study done by the University of Arizona in 2020, 400,000 women, and it showed that women that took estradiol replacement therapy for six years or longer in menopause had a 79% reduction in Alzheimer's and 77% reduction in dementia.

Dang. You know, I've even heard similar things about guys who are on aromatase inhibitors or selective estrogen inhibitors that they could experience potential risk for Alzheimer's or dementia by suppressing estrogen. Probably for similar reasons. Yeah.

And same with your bone health and your erections. And sex drive. Like, estrogen is really needed for women's sex drive especially. But you guys, too, if you. If yours gets too. If yours gets too high, it's a problem, but if yours gets too low, it's a problem, too.

Gets annoying during movies when you're crying, know, during all the sad scenes.

Yes. Yeah, exactly. So we have three main estrogens. There's estrone, which is a more inflammatory estrogen. We produce it out of our fat cells. Estradiol and estrone can convert back and forth to each other, and then they both convert down into a really weak form of estrogen called estriol. And estriol we produce boatloads of when we're pregnant. So it's considered the pregnancy estrogen. When we're in menopause, a lot of doctors will insist on using bias, which is a combination of estradiol and this really weak form of estrogen called estriol. And that's because it's been shown to be really breast protective because it doesn't sit on a receptor that causes proliferation. And it's really great for vagina health and really great for skin. So I tend to. In my. In our practice, we tend to use the estradiol because estradiol needs to get to a certain point in menopause on hormone replacement therapy to give us the bone, brain, and heart protection that it can give. And so if you're combining it with estriol, and usually it's. They'll do an 80% estriol with a 20% estradiol. That's too. It's too much of the. You end up using way too much estriol. And so I just don't agree that we should be trying to mimic pregnancy levels in menopausal women. It's just like. That doesn't make any sense to me. So everything that I've read is all estradiol. Estradiol. Estradiol Estradiol is the one that's giving us these incredible benefits. It's giving us our skin, our bones, our brain, like everything. And so. And we have estrogen receptors, estradiol receptors, on every organ in our body. It's like we're rich with them in the brain. It's not just about Alzheimer's. It's about how we think. And there was a study done that showed that women that use 2 milligrams of estradiol, their hippocampus, part of their brain volumized, it grew. And the women that weren't on it or were on 1 milligram of estradiol didn't have any effect. Their brain did not change. And when the women went off that 2 milligrams, the hippocampus gray matter went back to the regular size. So it actually helps your brain to volumize. And so estradiol, I like it for that. But I do have a bias. I love it for vagina because it's really good for lubrication and moisturizing and atrophy of the vagina. Super excellent for a face cream. It's been shown to shrink your pores by 60 to 100% within six months. Same with estradiol on the face. Builds collagen and even decreases the depth of your wrinkles.

Wow. I had no clue. And I'm assuming, based on your description of it, this is transdermal? The estradiol.

This is transdermal? Yeah. I'll send you and your wife some.

Oh, wow, fantastic. I'll keep that next to progesterone for times of need. When I need a.

Just use a little baby amount.

Yeah, yeah, yeah. And you said for the face, what would be the other benefits for a guy? Just cognition, facial health.

Yeah. You'd have to be careful because men tend to be estrogen dominant right now.

Okay.

Right. Because not you, Ben, but a lot of guys because they're unhealthy or if they've got weight gain or anything like that. They're testosterone.

Synthetic estrogens.

Synthetic estrogens. There's so much of them. But the research shows that if you're using just enough to just moisturize your face, it won't raise levels systemically. So if you were to just use, like, a little pea size on your face once a day, then it really helps with that. Actually, I taught John that, and he ended up putting it in his face cream in one of his face creams.

Oh, doctor. Dr. John Laurence. That's interesting. I remember seeing that in the face cream. I was kind of wondering about that. Yeah. That's interesting. So, in terms of these, these different estradiol, progesterone, testosterone, I assume all of this is prescription. There's no OTC options for management of something like this?

No, there is. The only one we can't get otc, of course, is testosterone. So testosterone is classified as, you know, classified four or whatever. Class four. Is that what it is down in there in the States?

Yeah. Which I guess would make sense because if we're talking about. I know my wife orders progesterone without prescription, you just offered to send me estradiol and you know, that would be a big no no if it was a prescription. So progesterone and estradiol you can get over the counter and then testosterone would be prescription, correct?

Yeah. And I have one of the only estradiol, only over the counter creams, because most people won't do it because of the fear of estrogen. So mostly you're going to find biased over the counter. You will never find estradiol unless you go to Karen's website. And it's just a low dose, because I do think that you should be monitored with higher doses. You want to be working with a practitioner with hormones as best you can, as everybody should, if they can, no matter what, because hormones are so. Everybody's so different and how you react is so different that there's. There's so many nuances to it, but a lot of people can't afford it. So I created my own line for people that just, you know, they, they want the help. Their doctors aren't giving it to them and they want to try progesterone cream for their symptoms. And it's like, now, now it's available. So.

Yeah, now, now. What about dhea? How come you haven't mentioned that yet?

I love dhea. I do. Or I prefer oral DHEA over transdermal in small amounts. So a lot of it, a lot of practitioners will be like, oh, yeah, use 50 milligrams, you don't want to do that. Because like testosterone, DHEA can also convert down into a more androgenic pathway. So. And we have a lot of DHEA receptors in our skin, so it's in a higher dose. A lot of women will get acne and hair growth from dhea. But DHEA is great, especially for women that have cortisol issues like low adrenal status, which tends to happen later on in perimenopause and menopause. Your DHEA will go down with it. And DHEA can, when you bump it up, it's very anabolic. Rather, cortisol is very catabolic, so protects the muscles really great for insulin resistance and blood sugar control. And then it's a pro hormone, so it helps us to make testosterone, helps us to make estrogens. And it's an adrenal hormone. So it has all these different functions. It's on. It's at the top of the hierarchy. So testosterone and DHEA are a woman's most abundant hormones in her fertile years. Not estrogen, not progesterone, testosterone and dhea. And all of your estradiol is made from testosterone in your ovaries. So your ovaries make testosterone, which then will make estradiol. So I always say it's like kind of man makes woman.

Interesting. So with dhea, are you actually testing to see if cortisol is dysregulated and then saying, okay, we're going to throw DHEA into the mix also?

Yeah, yep. And then we do that through the Dutch test. Blood. You cannot test cortisol with blood. It's just giving you the snapshot in time. Cortisol, we need to see what the rhythms do. We need to see is that, you know, coming up in the morning and then tapering down as the day goes on and then overall 24 hour cortisol production and then how you're metabolizing it.

Right. And the metabolizing is important because, you know, someone might, for example, be making adequate cortisol but showing like really low cortisol metabolites due to hypothyroidism or something like that. That's where the Dutch test is very interesting to know upstream and downstream metabolites because often you don't know whether it's a clearance issue or whether it's an actual issue with, with subpar production.

Yeah, like, you don't know how many women that I have been able to go, do you know, you have hypothyroidism. And they're like, what? From my Dutch test, you can see that I'm like, yes, like 95% of the time, if your metabolized cortisol is low or under range, you. You've got hypothyroidism.

Right. Right. Now, how about peptides? You hear those talked about a lot now as either alternatives to some type of hormone replacement therapy or an adjunct to them. Are you using peptides at all?

Lots. Yeah. Yeah, lots, yes. So I have a peptide group that is mostly focused on using weight loss peptides. Seglitide and tirepatide for women in perimenopause and menopause, because menopausal waking and perimenopausal weight gain is some of the most stubborn fat to get rid of. And I, I, I, I attract lots of healthy women into my practice, tons and tons that are doing all the things and they can't get the weight off. And they, these women were women that, you know, we're 115 pounds or 110 pounds their entire life and they hit perimenopause or menopause and they can be extreme athletes. They can be, you know, eating perfectly and they pack on £20 and cannot get it off even when they replace and optimize their hormones and doing all the things. And so we wanted to like, having these peptides has been a huge blessing because women are now getting their physique back so that the hormones are giving them their life back for some of them, and they're their libido back and their skin back and their hair and they're feeling good and emotionally stable. But then the body wasn't catching up with some of them. And so not with every woman. Some women, they take hormones and it's like, boom, they lose all the weight and they're happy. It's great. But a lot of them, they get stuck. And so the peptides really work well with hormone replacement therapy and so the women can shed that extra weight that they gained. Plus they're getting the hormones and they feel great. So it's been great. But we're also using like BPC157 for.

Yeah, I was going to ask you, like, which peptides specifically was used for the hormone support piece.

We do the BPC157 because it's so great for gut health, which then of course is going to help you to metabolize your hormones. Cgc, ipamorelin. So that's the growth hormone. Some women do really well on that. I personally did not. I crash and burn. But a lot of women do well, especially if they're doing the weight loss peptides. Those two are great to add into it because the growth hormone can obviously help you to help to protect the muscle if you're not eating enough. Right. So, and then we, we all use the Kion Aminos. That's our number one recommended supplement in.

Our checks in the mail.

Yeah, it is. No, it's been great. I love Kion. I love Angelo. I just had him on the podcast. I actually met Angelo in person last year.

Yeah, yeah, like co founder and CEO of Kion.

Yeah, yeah, he's great.

Obviously a good friend of mine.

Yeah, obviously. Yeah. So we do those melanitan a little bit. Like, I just. I've just personally tried melanitan. Oh, that made me feel super sick. But that one, you know, can give you your skin color, so it's nice protective of the skin, so it gives you a nice tan. We're. We're exploring a little bit with some people that are looking for an increase of sex drive, because that's definitely something that happens in menopause, is the lowering of sex drive. So we've had some women try oxytocin. We've had the, you know, PT141. So we've used it. We've tried a couple of those. The tadal cream that you can get at peptide sites. We've had some women do the nad. So we're not super focused on peptides. But my. One of my coaches, she is a peptide expert, so she absolutely helps people in our groups to, you know, figure out which peptides could be good for them.

Yeah. Now, hopefully this isn't a dumb question, but when it comes to this idea of managing perimenopause and menopause, is the. Is the strategy to stave off menopause for as long as possible or to simply ease the transition into it?

I feel like it's. It's to ease the transition because a lot of women really look forward to losing their period. I wanted to stay, so I completely reversed mine and I. I had my period up until last year, and then I went into men and pause. But I was able to completely reverse it. And I really wanted to hold on to my cycle for a second.

When you say reverse it, what do you mean?

So I started to lose my cycle at 42, so I was going into menopause. So menopause is considered one full year without a. Without your period is one day. It's one day. It's the first day after one year without a cycle, then you're considered menopausal. And then after that day is post menopause, which is really stupid. They just came up with that number. I just think, you know, if you started losing your period, you're going into menopause. So.

Yeah. Why. Why wait? Why wait a year to officially announce it?

So stupid. So I was going there. I had missed my period. Like I said, I was having all the symptoms. My hormones were dropping. So I replaced my hormones to a level that brought the period back.

And so a Lot of women will continue to do that. We do cycle hormones for women so that they'll continue until as long as they want. We have some women that are in their 60s that still actually get a once a month, just a slight bleed, but that's just because their estrogen's at a high enough dose to give them the protection for the brain. And it causes a little bit of a bleed because they're cycling the hormones. Some women, they choose to do static hormone dosing so that that means they would do progesterone and estrogen every single day at a steady dose, the same dose, and then they wouldn't get a cycle. And so those women will eventually, you know, they, they would lose their period and then they would continue with the static dosing so that they never got their period again. I personally will probably eventually do the rhythmic dosing because I think it's better for receptor health to do some cycling like our bodies naturally do.

Okay, we talked about peptides and dhea, but another one I wanted to ask you about that I see recommended a lot for estrogen dominance is dim. Di indole, methane. Okay, so dim, you know, cruciferous extracts, cruciferous vegetables, broccoli, broccoli sprouts, et cetera. You see those recommended a lot for estrogen dominance in both men and women. What do you think about dim?

It's also rec. Highly recommended by practitioners for menopausal women, too. Pellet clinics. They. It's like automatic. Every single woman is put on D and D methane, dim. So D and D methane will lower estrogen levels. And so it's great if you truly have too much estrogen, which actually very few women do. So let's just be very clear about that. Every woman thinks she's estrogen dominant, but when you actually look at her levels, they're fine. It's usually that progesterone drops. So in comparison to their progesterone, they have too much estrogen.

So. So it's more a ratio issue. Not that there's too much estrogen. It's the ratio of estrogen to progesterone.

Yeah. And then the. When we look at the metabolite test through the Dutch, remember I was talking about phase one hydroxylation. There's a pathway for hydroxylation that is the most toxic of these three pathways. And we see that that causes the most DNA damage, that women that do get breast cancer will have a higher level of 4 hydroxylation. And then there's 2 hydroxylation, which is the safest of these three pathways, DIM will make it so that your body will push down the 2 hydroxylation and take out of 4 hydroxylation. So if you did a test and you actually saw, wow, my 4 hydroxylation is elevated, I do produce a lot of estrogen. Let's say you've got really high levels of estrone or estrad or you're, you know, least over what, you're definitely way over what your progesterone is. You could use DIM to push down that path. You know, it works excellent for that. But willy nilly ing the dim is not a good idea because if you have estrogen dominance or you have too much in comparison to your progesterone, a what if your estrogen's not that high? What if you're close to menopause and your estrogen's dropping and you're gonna go take dim and it's gonna then deplete your estrogen faster and that's gonna push you into menopause faster, which will give you a lot of symptoms very quickly.

Yeah. And I, I assume based on what you described about estradiol, if it affect would also potentially cause issues with brain fog or things along those lines.

Oh, yeah. Terrible. It's terrible. We don't, we want to hold on to that, that estrogen is, is what makes us feel the best. And that'll cause the loss of estradiol, will cause more weight gain than an excess of estradiol. Always remember that. Because estrogen's needed for insulin sensitivity, leptin sensitivity. That's why we gain so much weight, is the loss of estradiol, progesterone a little bit. And testosterone will contribute to weight gain. But estrogen, estrogen loss is number one. So we don't want to be draining our estradiol, we want to be coveting it. So you have to be very careful there. And then the second thing is, is set. Phase two is methylation. So you may be held up in that phase. So if you go start taking dim, you're going to start dumping out this estrogen. But if you're not methylating it out, well, it's going to back up into the system and you're going to get higher levels and cause problems.

That makes sense. When I talk to a lot of male hormone specialists, they're also recommending other things like everything from ice baths to red light therapy. I've seen pulse electromagnetic field therapy recommended, you know, mitigation of EMF or the cell phone in the pocket. Are there certain things from a lifestyle or even a biohacking technology standpoint that you're also implementing in your practice or recommending to women that go beyond just the.

It will help them to like, slow down that process beyond the drugs.

Yeah, like other. Other lifestyle practices or biohacks.

There is. They're all. We always start with lifestyle. I mean, we. We always want that in there. But a lot of the time it's. You can't biohack your way out of it. Like I said before, like, you men have it a little bit easier because there's a lot you guys can do to restore testosterone. But once her ovaries shut down, they shut down bioregulator peptides. I have seen slow down the transition to menopause in just a couple people because not a lot of people use them. But I have seen it in my practice, like a before and after Dutch test of levels after taking the ovarian bioregulator peptide.

I was going to say there's like a few dozen different bioregulate letters, but you're using the ovarian one.

Was using the ovarian one. And I've used it now with women that are having infertility problems. I do use it with them and I want before using hormone replacement therapy because it can help restore the ovaries for them. There are certain herbals that can help nourish things like supplementation. Stress management is huge. Cortisol will block the receptors. And so women can feel like they have no estrogen when they have plenty because their cortisol is really high, is blocking those receptors. And so, you know, lowering stress levels, of course, is going to be huge. Lowering inflammation, making sure your gut's healthy. All of these things can help with the journey in. But a lot of it's genetics. You know, when you're going to hit menopause and once your ovaries start going, they just start going. There's no bringing them back.

So when it comes to that ovarian bioregulatory peptide, is that. Do you know the name of that one? Because I've got all sorts of funky names. These bioregulators.

Yeah. And it's not like ova or something. You know what I mean?

Yeah, it's not intuitive. Yeah, it's.

It's not. And so I can't. No, I don't remember it right now.

I'll look it up in the. Yeah, I'll put it in the show notes. Because these bioregulators, every time I go.

To use it, I have to go look it up.

Right. And unlike other peptides, very short amino acid sequences that can target a tissue and organ very precisely.

Very precisely. They, they have incredible research behind them. Our, our mutual friend Nat Netum. She's come on my show lots to talk about bioregular peptides and just how you can use them for women's health for many different things. Even thyroid function. Thyroid will go down like the rest of our sex hormones. And there's a really good bioregulator for your thyroid. So taking the thyroid, the ovarian one, even the blood vessel one, because you know, women is our number one killer is, is heart disease. So taking the blood vessel one, she says, really important, there's a bone one. Women will start to develop osteoporosis, especially if they don't replace their estrogen and progesterone and testosterone because it's so important for bone health. So that can be a great addition to it as well. I'm not the expert on bioregulators, so I wouldn't. You go check out that.

Yeah. N Matt Nidham's podcast, Shout out to Nat. I have a podcast with Phil Micans that I'll link to in the show notes that I've done on these bioregulator peptides. I wanted to ask you also, Karen, because a lot of women get concerned about weight gain during perimenopause and menopause. Besides the strategies that you've just outlined, is there anything specific that you do for the weight gain piece?

Yeah, yeah. So number one, yeah, you got to lift weights like across the board. It's like that is the number one thing that you need to do is to put muscle on. And you got to tamper down on the cardio because the cardio is going to stress the system out. It's going to cause more problems than, than.

And you don't mean walking in the sunshine. You probably mean like training for a triathlon or marathon or something like that.

Like the cardio bunnies that are out there going, I'm gonna go, you know, go on my step machine for two hours straight and then go running, you know, which a lot of women think that that's the only way that they can lose weight. And they're very highly addicted to the.

Cardio Peloton spin classes, 5Ks, which are, you know, they can be great for VO2 max and metabolic health. But you're right, the I, I always see better weight loss effects coming from low level aerobic cardio paired with weight training and lifestyle modifications.

Yeah. And then it's you know, as you've talked about lots is it's our biggest glucose processor, right. So because our metabolic health gets really bad. I mean, every woman's blood sugar is going to go up when she starts losing her, her hormones, like mine went up and I'm like my perfect blood sugar my entire life and it went up and I was like, what? And so that's the loss of mostly estrogen that's causing that. Your cholesterol goes up because you're the loss of estrogen and thyroid. They'll both affect insulin and blood sugar cholesterol. So you have to put muscle on to help with that metabolism. Without progesterone coming in, your, your metabolic rate does go down a little bit. Same with thyroid, right. It's going to have an effect on your metabolism. And we know the more muscle, the more thermogenic you're going to be. So it's like, it's just the number one thing and then it's also going to protect your bones. And so doing that, walking outside in the sunshine, like really into circadian health because that has so much effect on our blood sugar, on our leptin, on our sleep, all of those good things. So doing all of that I think is like number number one. And then.

Exercise wise, I have a Caro bike now which has been really handy. Do you have a Carol bike?

It's right behind me. You can't see it because I have this dumb green screen up. But yes, it's great. If I, if I've got no time and I'm locked away in my office on a busy riding day. Yeah, 10, 15 minute. What about the weight training? What does that look like for you?

I, I really like weight training. I'm not a cardio person, so I can weight train very easily, like four to five times a week, no problem.

And what would a typical workout look like? Like you're recommending for women for sets and reps and weight.

At least if they can, three days a week, at least for 30 minutes, you know, if that's all they can get in. Great. And I really like, like there's this really easy set that we, that I teach them that has like, you know, you go through just super setting. You know, you do squats, you do shoulder press, you do bent over rows squats and you just boom, boom, boom, boom. And you just, you want to make sure that you can't get to eight. If you can get, if you can get to eight, you're not lifting heavy enough. So we're not talking like oh, five dumbbell weights. No, no, if you're getting to eight, you're not, it's not heavy enough.

Yeah, no, no Gwyneth Paltrow elastic bands here. Yeah, you're, you're right. That six to maximum of 10 reps. If you can exceed that, I use a rule of three. If you can go more than three reps over about 10, you probably need to increase the weights or adjust the tempo or adjust the lowering phase or do something to increase stress.

Yeah, one of our coaches, she's like a, she trains people in like heavy lifting contests. And then we have another woman that we have a whole library of videos for weightlifting for women because it's so key for menopausal women.

Yeah, absolutely. Well, Karen, I'm gonna link to all of your stuff. If folks go to BenGreenfieldLife.com Martell, you've got your telemedicine, you've got some of these products. I assume that we were talking about anything else that, that people can turn to for as far as wisdom or advice that you have on your website.

Yeah, we can prescribe in every state in the United States as well as British Columbia and Alberta and Canada. We do do testosterone therapy because that's kind of hard to find for women.

And then we also. So you can do private coaching calls but then we also have group coaching for it's more affordable option. We do, we do lab reads in our group coaching calls so you can get tons of help with what are saying and with the whole program on hormones and getting the lifestyle and the diet nailed down with the videos of all the weightlifting and it's, it's rich with tons and tons of content. And then we have a weight loss peptide group if that's all you're interested in. It's just the weight loss. And then my, my podcast, I have a top 100 iTunes podcast, the Hormone solution.

Forgot about that.

Yeah, I just interviewed Ben on it, so be on the lookout for that. We did a nice up close and personal with Ben Greenfield. It was great. So, yeah, and then there's so much on there. We've got, I mean I've, I've interviewed world renowned hormone experts and there's so much to be had on there.

Yeah. Yeah, you're definitely an incredible wealth of knowledge and I'm glad I discovered you and was able to have dinner with you and learn about what you do. So again, the Shownotes are going to be at BenGreenfieldLife.com Martel Karen's last name M A R, T, E, L. I'll include all the details, all of her information over there. And Karen, thanks so much for coming on the show.

Thanks for having me.

All right, folks, I'm Ben Greenfield, along with the great Karen Martel. Signing up from BenGreenfieldLife.com have a fantastic week.

Do you want free access to comprehensive show notes, my weekly roundup newsletter, cutting edge research and articles, top recommendations from me for everything that you need to hack your life and a whole lot more? Check out BenGreenfieldLife.com it's all there. BenGreenfieldLife.com See you over there. Most of you who listen don't subscribe, like or rate this show. If you're one of those people who do, then huge thank you. But here's why it's important to subscribe like and or rate this show. If you do that, that means we get more eyeballs, we get higher rankings. And the bigger the Ben Greenfield Life show gets, the bigger and better the guests get and the better the content I'm able to deliver to you. So hit subscribe, leave a ranking, leave a review. If you got a little extra time, it means way more than you might think. Thank you so.

Much.

RA.