In this video JJ Virgin outlines five common errors people make when using GLP‑1 agonists such as Ozempic, Mounjaro, or other weight‑loss peptides and provides evidence‑based strategies to avoid them. She begins by emphasizing the need to monitor muscle mass and body composition, citing a 2017 Advances in Nutrition review that shows high‑protein, low‑calorie diets combined with resistance exercise preserve lean tissue during weight loss. She then explains that many users under‑consume protein; she recommends 0.7–1 g of protein per pound of target body weight and tracking intake with tools like Cronometer. The third mistake is skipping resistance training, which not only protects muscle but also boosts endogenous GLP‑1 and improves insulin sensitivity. The fourth error is failing to address the underlying metabolic dysfunction that makes GLP‑1 deficiency common in obesity, insulin resistance, and non‑alcoholic fatty liver disease; she suggests dietary tweaks (lower carbs, more protein, fiber, timing), better sleep, and lifestyle changes to naturally raise GLP‑1. Finally, she warns against indiscriminate peptide dosing and lack of cycling, describing peptide mechanisms (slowed gastric emptying, CNS appetite control, insulin‑sensitizing effects) and urging work with a qualified expert to titrate doses. Throughout, she mentions supportive supplements—Akkermansia‑producing bacteria, allulose, and the bitter‑hop extract Calicurb/Amarasate—citing a 2023 randomized trial showing appetite reduction. She concludes by inviting viewers to explore natural alternatives in a follow‑up video.
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Using Ozempic or Mounjaro or weight loss peptides can be beneficial, and there are some crucial mistakes you want to avoid before you take the plunge so you can have a healthier journey towards your weight loss goals. Not all weight loss is equal. So let's talk about the first big mistake: not tracking your muscle and your body composition. Now we're going to talk about how to avoid muscle loss, because when people lose weight by eating less calories, they lose both fat and lean body mass if they're not careful. Now, this review article published in 2017 in the journal Advances in Nutrition synthesizes existing research on preserving muscle during weight loss. This review discusses the importance of preserving muscle mass during weight loss, as losing muscle mass can have a negative effect on physical function and metabolism. Weight loss diets often reduce muscle mass, but muscle strength generally isn't affected. Weight loss can improve overall physical function to reduce fat mass, but high protein intake can help preserve lean body and muscle mass during weight loss. But may not improve muscle strength and could have adverse metabolic effects. And both endurance and resistance exercises are beneficial for preserving muscle mass during weight loss, with resistance exercises also improving muscle strength. And then this review concludes with weight loss therapies including low-calorie diets with adequate protein intake and increased physical activity, especially resistance exercise, should be encouraged to maintain muscle mass and improve physical function in individuals with obesity. All right, so with that under our belt, let me give you some stats. In people with normal weight, over 35% of total weight loss can be from losing lean body mass. Now, now, if they regain the weight later, it's so unfair because they tend to gain more fat back. In overweight or obese people, about 20 to 30% of their total weight loss comes from losing lean body mass, and if they regain weight, they can regain their lean body mass too. And then I think of Don Layman, who says in a 3-day fast, 50% could come from muscle. Here's the reality: if you're following a poorly designed diet, whether you're using these drugs or not, you will lose fat and lean body mass. It's not the weight loss medications that are causing this problem. It is the poorly designed program. And that leads me to mistake number 2, and that is not eating enough optimal protein. When I think of these drugs, I think about why are they working and what's the issue here. And is the issue that we aren't producing enough GLP-1? And if we're not, what are some of the things that we could do naturally? Well, one One of the things that you can do to help naturally raise GLP-1 is eat protein. What you want to do is eat the right amount of protein for your target body weight, not the way you are currently, but where you want to go. So what is your target body weight? And then you're going to eat 0.7 to 1 gram per pound of target body weight. And what I have people do is eat this first, because if you are on these medications, likely your appetite's going to be down some, and we want to make sure that you are getting in the protein to be able to maintain muscle and tracking your protein intake. This is where you want I use an app. I use Cronometer and I make sure that I am tracking my protein intake on that app. So we're going to track it. You're going to eat it first. You're going to make sure you're eating the right amount for your target body weight. The other challenge people have, and they're not doing resistance training. There's a couple different reasons that resistance training is so key here. We know that exercise helps boost GLP-1 as well. But also one of the big reasons that we have lower GLP-1 that you have weight gain is due to something called insulin resistance. And that is where your body cannot hear insulin like it should anymore. Insulin's higher than it should be. It's not able to create the lower blood sugar response it should, and it's creating a lot of inflammation. Resistance training is one of the fastest ways to start to fix that insulin resistance. And resistance training is also going to help along with the protein, your body hold onto that muscle. And remember, muscle's your metabolic spank. It's going to hold everything in tighter. It's going to boost your metabolism. It's very expensive for your body to have to maintain muscle. It's very costly. Now I created a resistance training cheat sheet that you can get at jjvirgin.com/power. It's free. That if you're new to resistance training will help guide you how to do this. The next mistake is not fixing the reason you got here in the first place. So when I started looking at these drugs, I went, I think the most interesting thing is why are they working so well? Are we deficient in GLP-1? And as I started to look at all of this, I found that yes, It turns out that people who have obesity or are insulin resistant or have non-alcoholic fatty liver disease, which is apparently 25% of the population, do not produce GLP-1 like they should. And if you're not producing GLP-1 like you should, you're going to be hungrier, right? And you're going to also have trouble if you're insulin resistant. You're not going to be able to burn off that stored fat for fuel. You're not going to be able to access it, so you'll be hungrier. How do we start to improve this deficiency? They're using these drugs right now to help you, but along with that, you becoming more insulin sensitive, right? And how do you do that? That resistance training, lowering the carbs in your diet, lowering the ultra-processed foods, but replacing them with protein, moving more all throughout the day, especially after your meals to lower the blood sugar response to meal, and getting good sleep. You are going to start work on what can I do to heal my metabolism so I can start to support the natural production of GLP-1 so at some point I can start to lower the dose or even cycle the dose. So maybe get off of it altogether. Here's the thing, a lot of people are going on these medications and they're allowing them to get off a lot of other medications like their blood pressure medications or the cholesterol, etc. And that's fantastic. I'd rather use one than a bunch of other things. But if you start to work on this, you might get to a point where you don't need it anymore because you've got your body doing what it needs to do. So what are some of the ways that you can support the production of GLP-1? Well, Protein and fiber help support GLP-1 production. Exercise helps support GLP-1 production. And then there's some supplements that can help here as well. One of them is something called Akkermansias. It's a type of bacteria in your gut that has some really helpful qualities. When it interacts with specific proteins in your body, it triggers the release of a particular protein called P9. Now, this P9 protein prompts cells in your gut to produce GLP-1. And remember GLP-1, what's it doing? It's helping control blood sugar. It's lowering insulin and it's help reducing appetite. Plus Afrimancia also can have a thermic effect. It can boost the process of burning calories as well. Along with that, there's two other things that can help here. One of them is allulose. Now I got turned on to this by the company RX Sugar, who has been doing a ton of research on this. And what they found is Allulose doesn't raise blood sugar or insulin, so it's great to use if you're insulin resistant or diabetic. But again, where it's super cool is that it stimulates GLP-1, and so it actually can lower blood sugar after you eat. Now, there's one other cool supplement that you may be able to use in place of these GLP-1 agonists, and it's called Calicurb. So it can help with hunger, it can help with cravings, it can help manage healthy weight and appetite. It's from bitter hops. It's called Amarasate. It's a proprietary blend, helps you feel fuller longer, helps you feel more satiated. And they did a study and it was a randomized controlled trial. It was published in 2023 in preprints.org. And they looked at the effects of this bitter hops extract, Amarasate, on appetite and food cravings in women undergoing a 24-hour water-only fast. So they had 30 adult women. And they either got a placebo or one of two doses. They had a high dose, 250 milligrams, or a low dose, 125 milligrams, of this bitter hops-based appetite suppressant twice a day. And the results showed that both the high and low dose treatment groups experienced a significant reduction in appetite and food craving compared to the placebo. Now, over the last 8 hours of fast, hunger and food cravings were reduced by 100% and 120% respectively. So there was overall 30% reduction in hunger by using these. I will tell you, I've been playing around with this Calicurb-2 and the allulose. It's amazing. So here's the biggest mistake. I have been amazed as I've dug into the research on these peptides. And I think what's important, bottom line, is they're peptides. And what these peptides can do is quite amazing. So in the appetite part of it, as you know, it's mechanical. It slows down stomach emptying. But there's also a central nervous system impact on appetite for via neuropeptides. And it helps with insulin resistance. So it will help lower glucagon, pump out a little bit of insulin, lower blood sugar, and enhance insulin sensitivity. You'll better blood sugar imbalance. It also lowers inflammation. That secreting of the insulin can help you with muscle growth, and it also may block a little bit of myostatin. These are also regenerative, can help with improved vascular function, cardioprotective, good vasodilation. It might reduce blood pressure. It can help with neuro— with Genesis? And could I do some lower dosing and some cycling? And this is where you'd want to work with someone who's an expert in peptides and can titrate, because otherwise you're stuck in the prescription dosing of it, which seems to be really, really high and probably creating a lot of the problems. If you've heard all this and you're wondering if Ozempic is even the right choice for you, let's talk about what your other options are. So I want you to watch this next video where I talk about safe, effective, and natural alternatives to help you achieve your health and weight loss goals without some potential side effects.
