Escaping Metabolic Mayhem in Perimenopause with Dr. Stephanie Estima

15 Dec 2025 · 55 min
Episode

15 Dec 2025 · 55 min

0:00

Podcast episode (recorded Nov 15, 2023) in which JJ Virgin interviews Dr. Stephanie Estima about perimenopause and practical strategies to avoid what they call “metabolic mayhem.” They explain typical perimenopausal changes (cycle shortening then lengthening, progressive loss of muscle mass and fast-twitch fibers, increasing insulin resistance and worsening lipids), and describe how chronic stress/hypercortisolemia can interact with insulin to create metabolic dysfunction. Actionable recommendations include prioritized resistance training (squats, hip thrusts, deadlifts, pull-ups, rows), protein as an absolute daily target (rough rule: ~1 g protein per pound of ideal body weight; e.g., 50 g per meal as an example for a 150 g/day target), timing and protein quality (animal/soy higher bioavailability than many plant blends), minimizing alcohol, and getting targeted labs (fasting insulin, fasting glucose, full lipids, full thyroid panel, sex hormones timed to cycle, IGF-1). A downloadable lab handout with ideal ranges and timing is referenced and promised in show notes.

Questions this episode answers

Approximately 5–7 µIU/mL (she notes up to ~20 µIU/mL is often considered 'normal' by some labs, but she prefers ~5–7).

Aim for ~1 gram of protein per pound of ideal body weight (example: a 150 g/day target can be split ~50 g per meal).

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