The Missing Manual for Men's Health and Longevity with Dr. Myles Spar

15 May 2025 · 34 min
34:24

In this interview, host JJ Virgin and functional‑medicine physician Dr. Myles Spar discuss how to reframe men’s health as a performance issue and outline a proactive, metric‑driven approach they call Medicine 3.0. They stress the importance of seeking specialist help, measuring stress (cortisol, HRV), and using modern labs (ApoB, Lp(a), CRP, coronary calcium CT, genetics) to catch cardiovascular risk early. The conversation moves to muscle health, sarcopenia, and body‑composition testing (DEXA), explaining why muscle mass is vital for metabolism, insulin sensitivity, and longevity. They then dive deep into testosterone and estradiol, advocating for free/bioavailable testosterone and estradiol testing, optimal ranges (≈700‑1000 ng/dL total), and personalized aromatase management. Brain health is linked to inflammation, blood‑sugar control, and APOE4 genetics, with recommendations for exercise, sleep, stress reduction, and specific nootropics (lion’s mane, phosphatidylserine, citrulline). Exercise prescriptions emphasize strength, HIIT, flexibility, and core work, noting that strength training drives myokines that benefit heart and brain. Finally, they highlight the role of relationships for men, introduce Dr. Spar’s book “Optimal Men’s Health,” and his TEDx talk “Change your annual check‑up to a check‑in and live longer.” The key actionable takeaway is to measure the right biomarkers, set performance‑oriented goals, and use targeted lifestyle interventions to improve health and longevity.

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