The Surprising Supplement ALL Women 40+ Should Be Taking
15 Dec 2025 · 19 min
This podcast episode (hosted by JJ Virgin) targets women 40+ and centers on a supplement—urolithin A (branded Mitopure by Timeline Nutrition)—claimed to support mitochondrial health, reduce menopause-related fatigue, improve muscle strength/endurance, and benefit skin when used topically. The episode includes multiple sponsor/read ads (Earth Breeze, Wayfair, Monarch, University of Phoenix, Columbia, Toyota), personal anecdotes from the host, cited clinical trial outcomes (participants aged 40–64) and specific dosing recommendations (500–1,000 mg/day). The host provides promo links/codes and a standard medical disclaimer.
Chapters
Hey, it's J.J. here.
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Hey, JJ here. Can you believe how fast the holidays are knocking at the door this year? One minute it's pumpkin spice season, the next you're getting your guest room ready and wondering where their wrapping paper went. And that's when I turned to Wayfair. From bedding and towels to holiday decor and last minute stocking stuffers, Wayfair has everything you need to get your home and holidays together fast. And for way less. With Wayfair, I know I can refresh my guest room in no time. Maybe I'll add a soft new comforter or a few holiday throw pillows. With Wayfair, it's so easy and everything arrives super fast. Plus, there's free shipping for any order over $35 easy and total peace of mind. So whether you're hosting, gifting, or just adding those final festive touches, Wayfair has your back. And when the holidays wind down, Wayfair has everything you need to tuck it all neatly away. Smart storage solutions for every room from.
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I'm JJ Virgin, PhD dropout.
Sorry, mom turned four time New York Times bestselling author.
Yes, I'm a certified Nutrition Specialist, Fitness hall of Famer, and I speak at health conferences and trainings around the globe. But I'm driven by my insatiable curiosity and love of science to keep asking.
Questions, digging for answers, and sharing the.
Information I uncover with as many people as I can. And that's why I created the well.
Beyond 40 podcast to synthesize and simplify.
The science of health into actionable strategies to help you thrive.
In each episode, we'll talk about what's.
Working in the world of wellness, from.
Personalized nutrition and healing your metabolism to.
Healthy aging and prescriptive fitness.
Join me on the journey to better.
Health so you can love how you.
Look and feel right now and have the energy to play full out at 100.
Hey jj Virgin here.
Okay, real talk. So often the holidays sneak up on me. Travel, gifts, hosting, you know, all the things and suddenly it's like, wait, who.
Spent what and where?
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Some people think nature is like this, but actually it's like this. Mother Nature is not all sunshine and rainbows. Nature can be hotter than a sauna and colder than an arctic skinny dip. That's why Colombia engineers everything we make for anything nature can throw at you. Colombia engineered for whatever.
Ah, menopause, that full body fatigue, the muscle and strength loss. And let's not forget the wrinkles. I mean, there were times as I was going through it that I literally wanted to crawl out of my body and come back when it was all over. But guess what? It doesn't have to be this way now. What if there was a supplement that you could take that could dramatically help with all of these issues and then some. Something totally natural, in fact, something your body may actually produce. Well, stay tuned. It's not too good to be true. I'm going to be revealing what it is and how you can get started on it right away. You know, I've worked with thousands of women going through menopause, and I've heard it all. Plus, I've been there myself. You feel tired, and it's not like normal tired. It's like that total lack of motivation tired. Your body aches, you just can't perform or work out like you used to. And your skin seems like it started drooping overnight. You look in the mirror, you start messing around with your face. You know what I'm talking about here. Because you want to get back to your old self. Can you relate? While some of this may seem superficial, like that sudden weight gain around your belly, my mom, by the way, called it shifting sands, where your gut starts to look like your butt. But here's the deal. It actually isn't. These changes can make a big impact on your health, on your longevity, and on your overall quality of life. Now, you probably heard that as you age, you start to lose muscle size, which can lead to a dangerous condition known as sarcopenia. But worse yet, you lose even more strength and even more power. But what you might not know, because I didn't know this till a little over a year ago, is that there's a compound produced in our guts that can help counteract this. Check it out. This compound is called urolithin A, and it supports your mitochondrial health. Now, you may remember learning about your mitochondria and biology. They called it the powerhouse of the cell because it's where we produce energy. And because of that, if you've got poor mitochondrial function, it's literally one of those key hallmarks of aging. So improving it is really the secret to feeling great as you age. Now, I mentioned earlier that you may be able to make this compound when you eat certain foods like pomegranate, some berries, and specific nuts like Walnuts and pecans, your gut bacteria can metabolize them and may be able to produce, produce your lithium A. Now, I keep saying maybe because it turns out that not everyone has the ability to do this. In fact, only a small percentage of the population can. But don't worry, there's a hack for it. Urolithin A, once you produce, it helps your cells produce energy more efficiently. So it helps with that menopause fatigue. And over time, you feel even more sustained energy levels because of the way it's working on a deep cellular level to enhance your health. It boosts energy primarily through its impact on supporting mitochondrial health and function. Now, you've probably heard of autophagy. It's the big selling point of intermittent fasting. And by the way, it also happens if you do some caloric restriction or better yet, you do some exercise. It's basically where your body is taking out the cellular trash. Well, urolithin A activates autophagy in the mitochondria. It's a special thing called mitophagy. And it's the process of clearing out defective mitochondria and allowing the cells to replace them with new healthy ones. This rejuvenation of the mitochondrial network means more efficient energy production for you. And this process improves the overall function of your mitochondria. And because they're responsible for producing ATP. And APT is kind of like the dollars, the energy currency in your body, that means more energy for you. Now, besides that, urolithin A can also help reduce inflammation. And inflammation, of course, can also impact energy levels by creating the state of chronic fatigue. This is what I was experiencing when I just couldn't seem to recover from my workouts. Where was urolithin A back then? The bottom line is that when your mitochondria are functioning better, when they're, it's going to make a big difference when it comes to muscular performance. Now, here's the challenge. Remember I said only a small percentage of us can make this compound. It turns out that only 40% of us are able to. And if you're one of those lucky 40%, then you also have to be eating a lot of pomegranate berries and nuts to make a substantial amount of it. And that's what you need in order to combat all of those symptoms of menopause. This isn't really realistic. So the answer here is to supplement with it to ensure that you're getting what you need. So here's how I've got you covered, my friends at Timeline Nutrition make it super easy to do this with their Mitopure supplement. It's got 500 milligrams of urolithin a in each dose. Now, depending on your needs, you're going to want to take somewhere between 500 and 1,000 milligrams a day. By the way, they are the leaders in doing the research on urolithin A and the research is amazing. Research has shown that urolithin A alleviates fatigue caused by exercise and promotes rapid muscle recovery. In fact, There was a 2002 randomized trial that was published in Cell that found that oral supplementation with urolithin A increases muscle strength and that high doses of urolithin A positively impact exercise performance measures. They had participants aged 40 to 64 who saw significant, significant improvements in leg muscle spring strength, which, by the way, think about it, as we age, leg muscle strength is everything to protect you from falls and other injuries as you age. And they also saw a 14 increase in their VO2 max. VO2 max is a measure of your overall cardiovascular fitness and has been linked indicated as the number one most important indicator of how well you will age or all cause mortality. Now, those who had a higher dose of urolithin A also increased their walking distance by greater than 30 meters during this trial. And this is hugely important for mobility because remember, mobility is mission critical to avoid falls and injuries as you age. And here's what's super cool in so many of the trials out there. It's all men. Or it's even worse than that. It's young men. Not so with Mitopure. Over half of their study participants were women and in the peri or postmenopausal age range. How cool is that? So it is clinically proven to work for us women in Perry and postmenopause. And here's what the science says. Mitipure improves cellular energy. Mitipure improves muscle strength by 12%. Might appear improves muscle endurance by 17%. When I first started reading all of this, I literally looked at this and I told the team over at Timeline Nutrition, I go, this honestly sounds like exercise in a bottle.
I don't want to say that because.
I don't want someone to go, oh cool, I'll just take my topure and sit on the couch. That's not what I'm saying. However, it's amazing what it does. It is one of those few supplements that you take and you actually can tell the difference, which is why I take at least 500mg of mitrepure urolithin A daily. And depending on what's going on, I will bump it up to 1000mg. If I'm doing heavy travel, if I'm under a lot of stress, if I'm cranking up my workout, I bump it on up. Also, I use it topically. There's face serum, there's body lotion, there's cream. And here's what's really cool about this. I was at dinner the other night and a girlfriend literally said to me, and this has never happened, what are you using? What body lotion are you using? Your skin is glowing. I had gotten to a point where I was kind of getting self conscious about my arms because I was looking a little crepey. So this was huge for me because I like to go sleeveless. So just like internally, when you take it, you start to change. Remember the things that are happening you internally during menopause. You know, your skin's shifting too. And just like urolithinase helping those mitochondrial function, helping internally, it gives you big benefits for your skin health too. Because that mitophagy process is crucial for your skin cells. Because efficient energy production is essential for maintaining skin health and for its repair and regeneration. This makes your skin cells able to function optimally. Here's what happens with menopause. Skin starts to have slower cellular turnover and slower repair process. I bet you've noticed this. And when you boost mitochondrial function and support overall cellular health, urolithin A can accelerate the skin's natural repair and regeneration process. Which means for you a more youthful appearance, less wrinkles, better texture and that glow that my friend told me about. It's also got those anti inflammatory properties I talked about internally. It's got them for you topically as well. Menopause often comes around with increased inflammation and that also impacts your skin health and makes the aging process accelerate. Gets you dryness, gets you redness, gets you more sensitive. So when you reduce the inflammation with urolithin A, you're going to help alleviate a lot of those different skin issues I just talked about. And you'll have this more balanced complexion. You'll also protect the skin barrier and that's super important for retaining moisture and protecting against different irritants. And finally, collagen. Here's what's super cool. Urolithin A also supports collagen production. Of course, we know collagen is a critical structural protein in the skin. It's what gives you that firmness and elasticity. And when Menopause, estrogen levels drop, collagen production starts to decrease, too. That's why we're starting to get the wrinkles and the sagging skin. But urolithin A has been shown to support collagen synthesis and maintenance by improving the overall health of skin cells and reducing oxidative stress, which of course can degrade collagen fibers. And one more thing that urolithin A does is it's an antioxidant. And that means we're going to reduce oxidative stress and, and protect the skin from environmental damage that can be anything from the sun and pollution. So this is really important because as we age, we're more vulnerable to this. So they've done some studies on topical mitopure, and in just two weeks, topical mitopure visibly reduces the appearance of fine lines and wrinkles. Topically applied mitopure helps make skin cells act like younger cells by turning on the genes that promote collagen production. Now, 80% of the skin aging is caused by the sun. And topical mitopure helps to protect your skin from the damaging effects of those UV rays. So if you want some real support on your menopause journey, I would recommend doing what I'm doing, which is taking mitocure. Now, you can use the capsular powder sachets, which are easy to do. And I love the sachets saves. When I'm doing a smoothie, I love to travel with the capsules because it's easy. And then treat your skin, use the serum, use the cream, use the lotion. I've literally been using this for over a year and I do not leave home without them. So here's the special offer for you. You can go to jjvirgin.com mitopure and that's M I T O P P U R E and use the code JJ10 for 10% off all of the products. Again, that is. JJvirgin.com might appear to get started anti aging today. Be sure to join me next time for more tools, tips and techniques you can incorporate into everyday life to ensure you look and feel great and are built to last. Check me out on Instagram, Facebook and my website, jjvirgin.com and make sure to follow my podcast@subscribetoj.com so you don't miss a single episode. And hey, if you're loving what you.
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After 40 thanks for tuning in and.
I'll catch you on the next episode. Hey JJ here.
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Hello listeners, this is Anne Bogle, author, blogger and creator of the podcast what Should I Read next? Since 2016, I've been helping readers bring more joy and delight into their reading lives. Every week I take all things books and reading with a guest and guide them in discovering their next read. They share three books they love, one book they don't, and what they've been reading lately, and I recommend three titles they may enjoy reading next. Guests have said our conversations are like therapy, troubleshooting issues that have plagued their reading lives for years and possibly the rest of their lives as well. And of course, recommending books that meet the moment. Whether they are looking for deep introspection to spur or encourage a life change, or a frothy page turner to help them escape the stresses of work, school, everything, you'll learn something about yourself as a reader and you'll definitely walk away confident to choose your next read, with a whole list of new books and authors to try. So join us each Tuesday for what Should I Read Next? Subscribe now wherever you're listening to this podcast and visit our website. What Should I read next podcast.com to find out more.
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