The Truth About the Keto / Ketogenic Diet with Dr. Sarah Ballantyne

15 Dec 2025 · 44 min
Episode

15 Dec 2025 · 44 min

0:00

Podcast episode (Dec 2018) in which JJ Virgin interviews Dr. Sarah Ballantyne about ketogenic diets. They review the diet's history and original therapeutic use for refractory epilepsy (early protocols were ~80% fat, ~10% protein, 5–10% carbs), explain underlying biochemistry (ATP/Krebs cycle, metabolic flexibility), and contrast therapeutic applications (neurological disease) with off-label fad uses (weight loss, cancer). Dr. Ballantyne describes short-term symptoms ("keto flu": lethargy, headaches, brain fog, GI issues) and longer-term risks observed in studies including immune suppression, kidney stones, lipid changes, menstrual disruption and thyroid suppression (one cited long-term study found ~1 in 6 patients developed hypothyroidism, mostly within the first month, requiring hormone replacement). JJ and Sarah close with practical weight-loss guidance emphasizing higher protein, abundant non-starchy vegetables, moderate carbs for many people (roughly 30–40% of calories), caloric deficit, sleep, exercise, and adequate micronutrients.

Questions this episode answers

About 80% fat, ~10% protein, 5–10% carbohydrate.

About 1 in 6 patients developed hypothyroidism (most within the first month; all within six months) and required thyroid hormone replacement.

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