What Are the 5 Stages of Progression With Hashimoto’s?

15 Dec 2025 · 11 min
Episode

15 Dec 2025 · 11 min

0:00

This podcast episode (Ask the Health Expert) hosted by JJ Virgin features a listener question about the five stages of progression with Hashimoto's disease. Guest Dr. Bill Cole (functional medicine expert) outlines a five-stage model: (1) genetic predisposition with no symptoms or antibodies; (2) immune cell infiltration of the thyroid with antibody elevations (TPO, Tg) and early symptoms often linked to intestinal permeability; (3) subclinical hypothyroidism with elevated TSH but normal T3/T4; (4) overt hypothyroidism with low T3/T4 and higher TSH often requiring medication; and (5) progression to additional autoimmune diseases. The episode also includes multiple sponsor/read ad segments (Earth Breeze, Wayfair, Monarch, Buffalo Trace, Columbia) and short promos for other podcasts.

Questions this episode answers

TPO (thyroid peroxidase) and Tg (thyroglobulin) antibodies.

About 80–90%.

TSH (thyroid-stimulating hormone) test.

70% will develop a second autoimmune disease; of those, 50% will develop a third.

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