What Health Benefits Does Fasting Have Besides Weight Loss?

15 Dec 2025 · 6 min
Episode

15 Dec 2025 · 6 min

0:00

Podcast episode (Ask the Health Expert) hosted by JJ Virgin (four-time NYT bestselling author). Uploaded June 14, 2021. JJ asks Dr. Will Cole (functional medicine practitioner and author): "What health benefits does fasting have besides weight loss?" Dr. Cole discusses mechanisms and benefits beyond weight loss including induction of nutritional ketosis (beta-hydroxybutyrate production), anti-inflammatory signaling (downregulation of NF-κB, COX2, NLRP3 inflammasome), increased autophagy, increased stem cell activity, mitochondrial biogenesis, and effects on the gut microbiome and immune system. Episode contains multiple sponsor ad reads (Earth Breeze, Wayfair, Monarch, Ray-Ban Meta Glasses, Buffalo Trace).

Questions this episode answers

June 14, 2021.

Dr. Will Cole; named one of the top 50 functional medicine and integrative medicine doctors in the nation.

Beta-hydroxybutyrate (referred to as a ketone body and 'the fourth macronutrient').

NF-κB, COX2 pathway, and the NLRP3 inflammasome.

90 proof; 45% alcohol by volume.

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