What Women Over 40 Need to Know About Fasting and Hormones With Dr. Mindy Pelz

15 Dec 2025 · 42 min
Episode

15 Dec 2025 · 42 min

0:00

Podcast interview (JJ Virgin with Dr. Mindy Pelz) focused on fasting, muscle maintenance, and hormone-aware nutrition for women over 40. Key themes: the need to manage stress/parasympathetic function to protect muscle (adrenal compensation after ovarian decline); balancing autophagy (cellular cleaning during fasting) and mTOR (growth during feeding) via a fasting lifestyle; concrete protein guidance (~1–1.5 g per pound of desired body weight and ~30 g protein pulses to trigger muscle mTOR); cycle-aware fasting strategies for perimenopausal women and a weekly 4-2-1 framework for menopausal/postmenopausal women (four moderate fasting days, two higher-carb/progesterone-support days, one extended fast/stretch day). Also discussed: practical markers (HRV, CGM, sleep trackers) over scale/BMI, and behavioral tips for retraining relationship to food.

Questions this episode answers

About 1.0 to 1.5 grams of protein per pound of the body weight you want to be; pulse roughly 30 grams of protein every few hours during the eating window to stimulate muscle mTOR.

Autophagy generally begins after roughly 15–17 hours of declining/stable blood glucose (transcript cites ~15–17 hours).

A 13-hour daily fast was cited: women who fasted 13 hours per day after traditional breast cancer treatment had a reported 64% lower recurrence (as mentioned in the episode).

The episode named 36-hour and 48-hour fasts and referenced Valter Longo's 72-hour immune-reset as options to pulse in occasionally.

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