Meet the New Thiel Fellows, GPT 5.5, Thoma Bravo Loses Medallia | Victor Boyd, Alex Shieh, Nick Dobroshinsky, Ishan Gupta, Antoni Kiszka, Milan Lustig, Galen Mead, Aubrey Niederhoffer, Samuel Carvalho, Claire Wang

23 Apr 2026 · 131 min
Episode

23 Apr 2026 · 131 min

0:00

In this live TVBN UltraDome podcast recorded on April 23, 2026, hosts John Coogan and Jordi Hays guide a rapid‑fire tour of emerging tech ventures from the new Thiel Fellowship class and beyond. The conversation begins with Ishan Gupta explaining how large‑language‑model agents can finally automate the high‑value services layer of recruiting, turning a $70 billion market into a potential AI‑driven holding company. The show then moves to Derpetual’s founder Antoni Kiszka, who describes a meme‑coin derivatives exchange and his roadmap to real‑world assets such as hydrogen, highlighting regulatory parallels with Kalshi. Next, Milan Lustig of Opt32 outlines a full‑stack compute stack for physical autonomy, from hardware‑agnostic model optimization to custom ASIC roadmaps, and discusses talent allocation in modern CS. The hosts briefly riff on a viral “anti‑Grammerly” product, then interview several Thiel Fellows: Aubrey Niederhoffer (Swoop) on building a low‑price super‑app in Nigeria and its payment‑cross‑sell strategy; Samuel Carvalho (Prozo) on end‑to‑end wholesale commerce infrastructure for Brazilian restaurants, low‑CAC growth, and short‑term credit models; and Claire Wang on neurotech, choosing C. elegans for whole‑brain emulation, and the synergy between brain‑computer interfaces and simulated nervous systems. The episode closes with market updates on Intel, Tesla, and a light‑hearted wrap‑up. Throughout, the hosts intersperse jokes, cultural references, and quick transitions, maintaining a conversational yet informative tone.

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