Lewis HowesYour Personal 24/7 Greatness Coach

4 Bacteria in People Who Live Past 100

10 Mar 2025 · 1 min

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In this brief lecture, the speaker highlights that the gut microbiome of people who live past 100 years consistently features four standout bacterial genera: Odoribacter, Oscillospira, Kristensenella, and Akkermansia. The discussion emphasizes that gut bacteria communicate with the immune system—about 70% of which resides in the gut—and that these specific microbes may convey signals that help the immune system function optimally, thereby supporting extreme longevity. The segment underscores the idea that having the “right” bacteria enables proper immune language, suggesting a mechanistic link between microbiome composition and healthy aging.

Chapters

Is there something in the gut microbiome in super agers, 100 and above, that pop out as important? Turns out there are four bacteria that are standouts in people that live to 100 and beyond. One of them is called Odoribacter, one of them is called Oscillospira, one of them is called Kristensenella, and then the fourth one is our old friend, Akkermansia. Okay. And, we've talked about Akkermansia before. Okay. Gut bacteria talks to your immune system. 70% of your immune system lives in your gut. And, so you've got the right bacteria, they know how to speak the right language to your immune system to tell it to do what it's supposed to do.