Episode

4 Dec 2025 · 46 min

0:00

Dr. Brian Mowll explains why 88% of Americans have metabolic dysfunction, how falling estrogen worsens it in women, and what actually works: resistance training, intermittent fasting, and monitoring fasting glucose and insulin levels.

Questions this episode answers

88% (cited from a 2019 population evaluation).

Fasting glucose should be in the 80s (mg/dL).

Waist-to-height ratio greater than 0.5 (> half your height) is a sign of insulin resistance/metabolic dysfunction.

Normal A1C: less than 5.7%; diabetes diagnostic threshold: 6.5% or higher.

Autophagy increases around 14–16 hours of fasting and peaks at about 48 hours.

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