394: Microdosing GLPs/Ozempic/Semaglutide for Metabolic Health with Dr. Tyna Moore

5 Dec 2025 · 61 min
Episode

5 Dec 2025 · 61 min

0:00

Interview between host Natalie Jill and Dr. Tyna Moore about GLP-1 agonists (semaglutide/Ozempic/Wegovy, tirzepatide/Mounjaro) and their applications beyond weight loss. Dr. Moore explains GLP-1 biology (endogenous peptide from gut and brain, pharma versions have longer half-lives), the drugs' history (discovered ~20 years ago; repurposed from neurodegeneration to diabetes and then weight loss), and advocates a personalized, low-and-slow "microdosing" approach for metabolically-optimized midlife patients. She frames metabolic dysfunction as the root of many midlife illnesses, promotes a triad for midlife women (strength training + appropriately-dosed GLP-1s + bioidentical HRT), and emphasizes working with knowledgeable clinicians, monitoring labs/symptoms, and prioritizing lifestyle (protein, resistance training, sleep). She discusses benefits reported anecdotally and in studies (improved glycemic markers, reduced inflammation, neuroprotective effects), practical dosing concerns (standard pen dosing ramps from 0.25 mg to 2.4 mg for semaglutide — Moore argues many patients are overdosed), safety issues (gallbladder/biliary risk, potential anxiety/ANS effects in some, slowed gastric motility at higher doses), and resources (free 4-part video series and paid course at drtina.com, plus a "find a doc" video).

Questions this episode answers

0.25 mg (standard initial starting dose cited in the transcript).

2.4 mg (reported study/top dose cited in the transcript).

Mounjaro (tirzepatide is the generic; Mounjaro the brand).

Ozempic (diabetes indication) and Wegovy (weight-loss indication); semaglutide is the generic name.

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